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Home Process Analytics TOC Analyzers and Bioburden Analyzers On-Line TOC Analyzer
Home Process Analytics TOC Analyzers and Bioburden Analyzers On-Line TOC Analyzer

On-Line TOC Analyzer

Real-time Analysis of TOC Contamination in Water

On-line TOC analyzers offer uninterrupted monitoring of total organic carbon levels for a range of water purity levels. With real-time results, continuous TOC analyzers allow for immediate, preventative actions when excursions are detected to offset potential contamination and ensure regulatory compliance requirements are met. METTLER TOLEDO on-line TOC analyzers feature a simple and low-maintenance sensor-style design for reliable TOC monitoring.
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On-line Total Organic Carbon Analyzer 6000TOCi

Monitoring TOC of water is critical to meeting internal water quality specifications and global pharmacopeia regulatory requirements. Missing an increase in TOC levels can put you at risk of contaminating your water system. This video explais how the  on-line total organic carbon analyzer 6000TOCi works.

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On-line TOC and Ozone Measurement For Pharmaceutical Waters

On-line TOC and Ozone Measurement For Pharmaceutical Waters

For a producer of medical biopolymers, a solution employing Thornton in-line multi-parameter measurements has significantly increased real-time response to system changes.

TOC Monitoring and FDA Compliance

TOC Monitoring and FDA Compliance

This case study explains how Acheson & Acheson, a privately-owned British-based company which designs, formulates, manufactures and supplies cosmetics products was looking for an analyzer for TOC monitoring.

Ultrapure Water Monitoring in Microelectronics Industry

Ultrapure Water Monitoring in Microelectronics Industry

This white paper discusses the rapid technological advances in the microelectronics industry. It explains that two critical parameters that must be monitored in real-time are resistivity and total organic carbon (TOC).

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What is total organic carbon (TOC)?

Total Organic Carbon is a term used to describe the measurement of organic (carbon based) contaminants in a water system. Organic contamination can come from a variety of sources, since "organics" are compounds such as sugar, sucrose, alcohol, petroleum, PVC cement and plastic-based derivatives.

  • Organics may exist in the feed water.
  • Organics may result from the leaching or shedding of various components within the purification or water distribution system.
  • Organics may result from the formation of biofilms (bacteria) in the water system.

How is TOC measured?

TOC can be measured both on- and off-line. Off-line measurements (lab methods) are typically used for high concentrations (>1 ppm). On-line measurements are typically used for sub-ppm (<1000ppb) detection and quicker response than the lab methods. Most of the industries Thornton services use on-line measurements for the faster response, which is required for process control.

Why are TOC measurements used?

Generally, organic contaminants are non-ionic and as such are not detected by standard conductivity measurements. Therefore, high resistivity (low conductivity) measurements in an ultrapure water system will not detect high levels of TOC from high levels of contamination. High levels of TOC can:

  • Degrade water purification systems.
  • Reduce semiconductor yields.
  • Contaminate pharmaceutical batches.
  • Damage power and steam generation equipment.
     

TOC measurement is used to monitor both the quality and equipment efficiency of many water purification processes. It is utilized in many of the industries and applications that METTLER TOLEDO services:

  • Semiconductor Industry
  • Pharmaceutical Industry
  • Power and Steam Generation

Where is TOC measured?

  • AfterReverse Osmosis to monitor membrane efficiency (especially where Thin Film Composite or TFC membranes are used).
  • AfterDeionization(DI) beds to monitor resin life and efficiency and to monitor shedding of new resins.
  • After the Final Polish to ensure low organic levels have been maintained after storage of pure water in tanks.
  • On Recycle (return of wet bench discharge waters) and Reclaim (reusing discharged waters in secondary applications outside the fab) lines, to ensure proper, low organic levels before return to the water system.
  • After TOC destruct UV lamps to monitor UV light efficiency.
  • Before the Point of Use distribution lines to ensure final water quality.
  • Monitor Boiler Feed water to prevent damage to turbines and other equipment.
  • To meet UPS <643> and EP 2.2.44 requirements. TOC is a pharmaceutical measurement required when producing USP purified water, WFI (Water for Injection), and HPW (Highly Purified Water).
     

On November 15, 1996, the USP allowed on-line TOC measurements as an alternative test method to existing offline heavy metals test methodologies. On May 15, 1998, the USP required TOC measurements as a new component of the test methodologies established in USP 23 <643>. The use of quantitative TOC measurements by USP 23 <643> replaced the previous laboratory USP test procedure, thus providing a qualitative test method. TOC measurements are used to monitor return loops from the point of use lines back to the storage tanks as well as in other areas of the water purification system.

What is a TOC analyzer?

A TOC analyzer monitors the amount of total organic carbon within a water system. METTLER TOLEDO on-line TOC analyzers offer reliable, real-time analysis to ensure excursions never go undetected and meet regulatory compliance requirements.

Are on-line TOC analyzers with continuous flow better than batch process TOC measurements?

Yes. An on-line TOC analyzer, which measures continuous flow, can "see" the whole representative sample of organics in the water system. Much like a movie with continuous frames, a continuous flow TOC analzyer doesn't miss a frame or a TOC excursion.

However, a batch process is like a single frame photograph that takes a "snapshot" of the system. If "snapshots" are taken periodically, TOC excursions can be measured erroneously, as in a portion of an excursion where the magnitude of the excursion is missed, or an entire excursion may be missed entirely! If a batch process TOC unit has a response time of 30 minutes, or even 5 minutes, significant and important information may never be identified until it's too late.

How can I ensure my on-line TOC analyzer is working properly?

METTLER TOLEDO on-line TOC analyzers are equipped with Intelligent Sensor Management (ISM) technology to provide reliable predictive diagnostics to reduce sensor downtime. ISM capabilities ensure that the on-line TOC analyzer, or TOC sensor, is working properly. Additionally, TOC sensors receive visual display indications when calibration is needed or when the UV lamp needs replacement.

Are chemicals, gases or reagents required for operating the 550?

No chemicals, gases or reagents are required for normal TOC measurements!

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