Using Data-Rich Experimentation to Enable the Development of Continuous Processes

Oxidative Nitration reaction with a fast and highly exothermic oxidation step using reaction calorimetry and process analytical technology

David Ford of Nalas investigated an Oxidative Nitration reaction with a fast and highly exothermic oxidation step using reaction calorimetry and Process Analytical Technology (PAT).

The methodology of and benefits of converting from a batch to a continuous process are presented, including:

  • Initial calorimetry screening to understand thermal risks
  • Application of Process Analytical Technology (PAT) to improve the stability of an intermediate
  • Improving mixing, yield and heat transfer by applying continuous stirred tank reactors (CSTR) in series


Who Should View this Presentation?

  • Chemists and Chemical Engineers in the Chemical, Petrochemical and Pharmaceutical industries as well as Academia.

Your Presenter
Upon receiving his B.S. in Chemistry at the University of California, Berkeley, David Ford performed his graduate studies in Professor Eric Jacobsen’s group at Harvard University. The theme of his thesis research was the use of physical-organic chemistry techniques to elucidate mechanistic details of catalytic reactions. After completing his Ph.D., he joined Nalas as a process chemist.  Dr. Ford has worked on using data-rich experimentation to develop sound process understanding, and also applied those insights to the design of continuous processes.