Why use Mid-Infrared ATR-FTIR Spectroscopy?
In many instances, reaction understanding requires the construction of accurate reaction profiles for each species that are expressed as concentration versus time, leading to the determination of reaction kinetics. In Situ Mid-Infrared ATR-FTIR Spectroscopy is an ideal technique to provide this information, as it allows the rapid collection of detailed reaction profiles.
What advantages does Mid-Infrared ATR-FTIR Spectroscopy bring to reaction analysis?
Mid-Infrared ATR-FTIR Spectroscopy brings a couple of advantages to reaction analysis. First, the use of the fingerprint region of the mid-infrared enables the individual tracking of chemical species, which in turn provides clues to the mechanism of the reaction. Second, Beer's Law gives the connection between the measured absorbance of the reaction species and its concentration. This relationship means we can use an offline measurement to determine the concentration of an offline sample, and then use that data point to scale the mid-infrared profile. There is a correlation between the concentration measurement of offline samples and the measured shape of the in situ samples.
Why use Mid-Infrared ATR-FTIR Spectroscopy instead of alternative techniques?
Mid-infrared attenuated total reflectance (ATR) technology offers numerous advantages over alternative analytical methods, including other molecular spectroscopy techniques. Researchers and scientists improve chemical development by leveraging these advantages, including:
- Immersible for direct insertion into reaction vessel for in situ, continuous, real-time measurements
- No extractive sampling required, providing the ability to measure chemistry in its natural environment
- Impervious to bubbles or solids, making it ideal for hydrogenations or any heterogeneous reactions
- Suitable for aqueous chemistry
- Non-destructive, preserving the integrity of the chemical reaction
- Adheres to Beer-Lambert law, enabling both qualitative and quantitative measurements
Instantaneous information can be gained about a reaction from ReactIR FTIR spectroscopy because it is an in situ technique. This is a key benefit to obtaining further insights into reaction behavior, particularly where transient species are involved.
Why is the data generated from Mid-Infrared ATR-FTIR Spectroscopy so important?
The reason why the data is so important is because of its continuous nature. With ReactIR FTIR Spectroscopy, data collection is automated, typically generating concentration information every minute, even as fast as four times every second. This means that rather than running a large number of reactions to understand rate dependencies, just a few experiments can provide the necessary information to determine the driving forces of a reaction supporting reaction mechanistic theory. This means that research can progress at an accelerated rate. In addition, the data is often more accurate than data analyzed by offline techniques as there is no possible alteration of the molecules by preparation for analysis, or by exposing it to an enviroment other than that within the reaction vessel.
What industries use ReactIR FTIR Spectroscopy?
ReactIR FTIR Spectroscopy is used in the pharmaceutical, chemical, and petrochemical industries as well as in academic research.
What is ReactIR FTIR Spectroscopy used for in the Pharmaceutical industry?
- Organic Synthesis
- Grignard
- Hydrogenations
- Crystallization
- Asymmetric Catalysis
- Halogenations
- Enzymatic Catalysis
- Cross Coupling Reactions
- Organometallic Chemistry
- Solution Phase and Heterogeneous Catalysis
What is ReactIR FTIR Spectroscopy used for in the Chemical industry?
- Intermediates
- Surfactants
- Flavors and Fragrances
- Coatings/Pigments
- Agrochemicals
- Initiators
- Bulk Chemicals
- Isocyanate Chemistry
- EO/PO
- Highly Oxidizing Reactions
- Hydroformylation
- Catalytic Processes
- Phosgenations
- Esterifications
What is ReactIR FTIR Spectroscopy used for in Academic Research?
- Metal-Mediated Chemistry
- Catalysis
- C-H Activation
- Mechanistic Studies
- Reaction Kinetics
