Your analytical instruments play a key role in your quality system. How can you ensure that they measure accurately? Reliable measurements help you maintain product quality and save money by avoiding costly mistakes. Additionally, how can you meet all regulatory requirements and adhere to both internal and external standards?
METTLER TOLEDO calibration and verification services document how accurate your measurement equipment is and if it is accurate enough for your specific needs.
The required calibration and verification service depends on several factors. These factors include the type of equipment, your industry, and the laws and regulations. They also consider your applications and the usage of the instrument.
METTLER TOLEDO will help you determine the optimal frequency of calibration and verification based on your conditions.
The accuracy of your titration equipment becomes less reliable over time due to wear and tear of the electronics and mechanical parts. Therefore, regular calibration is essential to ensure consistent equipment performance and adherence to technical specifications, which builds the basis of accurate and reliable titration results. Calibration of all sensor inputs, digital sensors, and burette drive stroke length using certified reference tools ensures performance and makes sure that your titrator is working according to its specifications.
The burette volume is calibrated individually in accordance with ISO 8655 Part 3 to ensure truly interchangeable burettes.
Calibration services are available for:
The dedicated GSST service is an additional service to complement preventive maintenance and calibration. It's a lifecycle service that verifies the performance of the complete titration system on a regular basis, available for METTLER TOLEDO general and Karl Fischer Titrators including the InMotion™ Oven Autosampler.
Running your density meter or refractometer at its highest accuracy requires calibration with certified reference standards on a regular basis. This allows verification of your adjustment parameters, ensuring highly reliable results over the entire lifetime of your instrument. External influences, inadequate handling of the instrument, or aging of the measuring cell might make an adjustment of the instrument necessary. If the calibration measurements are out of specification, a re-adjustment is performed to guarantee accurate results for future measurements.
Calibration services are available for:
SimpleCheck™ standards enable fast and reliable performance verification for EasyPlus™ instruments thanks to the built-in user guidance.
> Get to know more about SimpleCheck
For routine performance verification, combined certified reference standards from METTLER TOLEDO are available for Excellence Density Meters and Refractometers as well as portable meters.
> Download the Density and Refractive Index Combined Standards Datasheet
In order to guarantee the most accurate melting or dropping point measurements of your samples, regular temperature verification and calibration of your instrument is required. Our calibration service uses certified reference standards for calibration and adjustment if necessary (as found/as left).
For the MP80 instrument, which allows boiling point determination, the built-in pressure sensor is calibrated using a certified reference sensor.
The unbiased and fully traceable calibration certificate enables regulatory compliance and audit readiness.
METTLER TOLEDO reference standards allow accurate temperature verification of any melting and dropping point instrument during routine operation. Each high-purity reference substance comes with certified temperature values for thermodynamic and pharmacopeia modes. Reference standards are available in a range from 40 – 360 ͦ C.
Calibration services are available for:
Make sure your instrument is within specification and continues to be fit for purpose. Our calibration services use bespoke certified reference tools, specially designed to meet USP or Ph. Eur. requirements. *
CertiRef™ and LinSet™ performance verification modules offer a fast and secure solution for the calibration of UV/VIS Excellence Spectrophotometers. The plug-and-play modules equipped with certified reference materials (CRMs) run fully automated and provide full traceability of all test results, enabling regulatory compliance and audit readiness.
Calibration services are available for:
* Only UV7 Excellence guarantees compliance with Pharmacopoeia
Calibration ensures the optimal performance of your pH and conductivity meters. With our professionally trained technicians and certified tools, we deliver reliable pass/fail statements and comprehensive calibration certificates, providing documented proof of meter performance.
This service ensures compliance with local and global regulations, such as GLP, USP/EP, and DIN, and helps you avoid the costs associated with inaccurate measurements, ultimately safeguarding quality and supporting your internal standards.
METTLER TOLEDO thermal analysis calibration provides you with:
Standard Calibration for one heating rate per reference substance
Expert Calibration for three heating rates per reference substance
The calibration interval strongly depends on the individual application, frequency of use, and environmental conditions. Typically, the frequency is determined based on a risk assessment of the entire process where the equipment is used.
While METTLER TOLEDO provides recommendations, ultimately it is the user's responsibility to determine the frequency of maintenance and calibration required for their process.
Primarily, calibration should be performed onsite to consider performance under actual ambient/user conditions.
However, for some equipment (e.g.: titration burettes, portable instruments), depot calibration is available. Availability also depends on the local METTLER TOLEDO service setup/infrastructure.
Titration calibration is basically the verification of the technical specification of a titrator. For example, the burette drive stroke length significantly impacts the dosing accuracy, which is crucial to achieving accurate and reliable titration results. We use a certified micrometer and measure the stroke length at different levels (in accordance with ISO 8655) to ensure dosing accuracy over the entire dispensing range/burette volume. The burette volume is calibrated separately, according to ISO 8655 part 3, to ensure truly interchangeable burettes.
The accuracy of the sensor input is indispensable for proper potential measurements (e.g., mV/pH) to monitor the titration reaction and the correct EP/EQP evaluation. For calibration, we are using certified resistors and digital multimeter to ensure measurements are within specifications.
For the InMotion™ KF Oven Autosampler, the oven temperature accuracy and stability and gas flow rate are calibrated using a certified temperature sensor and gas flow meter.
The certificate includes a clear pass/fail decision based on maximum permissible errors from technical specifications and provides full traceability of all measurement results and tools used for calibration.
The adjustment builds the relationship between the measured signal/value and the result unit. This is the oscillation frequency for density measurements and the critical angle of total reflection for the refractive index, respectively. To be able to measure proper density or refractive index values, the corresponding measurement cells need to be adjusted using known samples/reference standards, i.e., water and/or air.
A calibration is performed using certified reference standards and establishes the difference between the actual measured value and the certified value of the reference standard. If the measured value is within the tolerances, calibration is passed. If the measured value is outside the tolerances, we recommend thoroughly cleaning and drying the measurement cell and then recalibrating, it before doing a re-adjustment of the measuring cell.
Our instruments are delivered with a factory adjustment, except for Excellence and Portable Refractometers.
Yes, it’s possible to calibrate the UV/Vis Spectrophotometer to be compliant with both pharmacopeias.
The main difference between USP and Ph. Eur. is related to stray light determination. There are two different procedures for stray light determination, i.e.:
Procedure A: Solution Filter Ratio Method (SFRM)
Procedure B: Specific Wavelength method (SWM)
While USP accepts both procedures, Ph. Eur. only accepts procedure B.
Using the CertiRef EUP enables performance verification and calibration for compliance with both pharmacopeias. For photometric linearity, either LinSet PDC or LinSet Niacin can be used for compliance with USP and Ph. Eur.
Please note that only UV7 Excellence complies with pharmacopeias.
METTLER TOLEDO reference substances, such as benzophenone, vanillin, benzoic acid, and potassium nitrate, provide temperature values that can be used for the temperature calibration of dropping point instruments.
Caffeine and saccharine cannot be used as they do not drop properly.
The basis for comparison is the thermodynamic melting point of the calibration substance that is detailed on the corresponding certificate. However, the dropping point of a reference substance is not equal to the thermodynamic melting point as it refers to the furnace temperature but not the sample temperature. Therefore, the temperature needs to be adjusted using a substance-specific correction factor.
The DP70 and DP90 Excellence instruments include an automatic procedure/method for temperature verification, and correction factors for each reference substance are stored in the instrument.