Hydrate Formation of L-lysine HCL Analyzed by Dynamic Water Vapor Sorption

ProUmid Application Note

Hydrates, in general, are substances which have formed bonds with water molecules. Water binding can take place via electrostatic dipole-dipole interactions, via hydrogen bonds or coordinatively in complexes. In inorganic, crystalline hydrates water molecules are bound in a specific stoichiometric ratio. Hydrates are usually built during crystallization from aqueous solutions. By drying and removing the crystallization water, the anhydrous crystal can be formed.

Application Note

The respective hydrate state influences the properties of the material, e.g. the dissolution rate, the compressibility or the bioavailability of a product. Furthermore, the high hygroscopicity of the anhydrate influences the storability and handling of the product. Therefore, identification and control of hydrate forms is important in the field of quality control, product development and material characterization.

Dynamic water vapor sorption (DVS) analysis is an effective method not only for determining the present hydrate species but also for determining the kinetics of hydrate formation as a function of temperature and relative humidity.