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Single-use pH Sensors

Ensure Reliable Measurement of pH in Bioprocesses

METTLER TOLEDO single-use pH sensors are designed to be securely installed into single-use bioreactors and other process devices. The sensors’ reliable measurement performance helps to optimize processes for the production of monoclonal antibodies, vaccines, and components for cell and gene therapies. Our single-use pH sensors are gamma- and X-ray sterilizable and are available in analog and digital format for seamless integration into your bioprocess environment.

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Nauwkeurige, betrouwbare pH-meting in bioreactorzakken voor eenmalig gebruik speelt een cruciale rol in batchproductiviteit en -opbrengst. De Mettler Toledo In-Sus 310 pH-sensor voor eenmalig gebruik is ontworpen om te voldoen aan de uitdagingen van de moderne bioprocessingomgeving. Deze volledig geïntegreerde, met gammastraling steriliseerbare pH-sensor is even nauwkeurig en betrouwbaar als onze herbruikbare glassensoren. De Insus 310 wordt tijdens transport en voorbereiding vóór de batch beschermd door beschermkappen met afgeronde randen, zodat de drie glaselementen niet breken. Het robuuste ontwerp zorgt voor volledige integriteit van de sensor en de zak. De sensor voorkomt ook dat elektrolyt en deeltjes tijdens droge opslag in de zak terechtkomen dankzij een speciale, in media oplosbare, biocompatibele beschermlaag. Insus 310 levert gedurende ten minste zes weken een betrouwbaar meetsignaal. Deze langdurige meetstabiliteit maakt gebruik van de sensor mogelijk in geïntensiveerde bioprocessing-, semi-continuïteits- en perfusieprocessen en waarborgt consistentie van batch tot batch. De sensor heeft een toonaangevende houdbaarheid van 30 maanden. Dit maakt verbeterde voorraadcontrole mogelijk bij fabrikanten van zakken en op locaties van eindgebruikers. De verbeterde beschikbaarheid van bioprocesapparatuur voor eenmalig gebruik maakt een snelle aanpassing aan toegenomen marktvraag mogelijk. Dankzij de hoogste integriteit van zak en sensor, een lange, nauwkeurige meetlevensduur en een verbeterde beschikbaarheid van zakken kunnen operators zich concentreren op het uitvoeren van batches zonder zich zorgen te hoeven maken over sensorproblemen. De Insus 310 pH-sensor is verkrijgbaar in wegwerpzakken voor celcultuur-, fermentatie- en mengtoepassingen van toonaangevende producenten van bioprocesapparatuur in single-use formaat. Wanneer nauwkeurigheid en betrouwbaarheid belangrijk zijn, vraag dan om installatie van Mettler Toledo InSus 310 pH-sensoren voor eenmalig gebruik in uw bioreactorzakken. Neem vandaag nog contact op met uw zakleverancier. Ga voor meer informatie naar www.mt .com slash InSus.

Single-Use pH Sensors for Bioreactors

This video introduces the single-use pH sensor InSUS 310 for bioreactors. The single-use pH sensor is designed for direct integration into single-use bioreactor bags. It meets the challenges of the modern bioprocessing environment. The single-use pH sensor provides a reliable measurement signal for at least six weeks, making it optimal for long batch processes.

Factory Calibration for Reliable pH Measurements

These single-use pH sensors are factory calibrated by METTLER TOLEDO to ensure that they are accurate and ready to measure in single-use bioprocess devices.

Longer Sensor Shelf-Life Enhances Inventory Control

With a shelf-life of 30 months, these single-use pH sensors enable enhanced equipment inventory control at the process device manufacturer and at end-user sites.

Robust Sensor Design for Protection During Bag Delivery

To ensure bag protection during transport and preparation, these single-use pH sensors have round-edged protective guards to prevent damage to the electrode inside of the bag.

Suitable for a Wide Range of Applications

These single-use pH probes can be used throughout a broad range of applications, including cell culture, harvesting, fermentation, media/buffer preparation, virus inactivation and purification steps.

Certified Materials for Established Process Safety

All wetted polymer materials used on single-use pH sensors are made of USP 88 VI certified materials to ensure the highest process safety to meet biocompatibility requirements.

Unique Design Ideal for Welding to Bag Stock

Single-use pH sensors from METTLER TOLEDO offer a unified design that allows safe and easy installation in a standard 1" Eldon James port disc, making them ideal for welding to bag stock.

Easy Integration with Dependable Output Signal

The output signal of these single-use pH probes is identical to that of METTLER TOLEDO reusable pH probes, to allow easy integration into existing transmitters and process environments.

Gerelateerde informatie

Differences in Operation Between Analytical Reusable and Single-use Sensors in Bioreactors

In recent years, the deployment of single-use bioreactors (SUBs) has become an important trend in the bioprocessing industry. SUB technology for mammalian cell culture and for microbial cells has achieved major breakthroughs regarding process safety and reliability in order to comply with the industry’s strict requirements.

Technical Data on InSUS Sensor Series

The InSUS™ sensor series for single-use technology bioprocesses cover the measurement parameters pH and dissolved oxygen (DO). These gamma irradiationsterilizable sensors have been designed especially for deployment in stirred single-use bags in the 20 –3,000 L range for applications such as: cell culture, fermentation, virus inactivation, and media/buffer preparation.

pH Measurement in Bioprocesses

To be able to measure pH in bioprocesses you need to have a pH measurement tool that is sensitive to the hydrogen ions that define the pH value. The principle of measurement is that you use a sensor with a glass membrane that is sensitive to hydrogen ions, and observe the reaction between it and a sample solution.

Analytical Measurements in Bioreactors: Conventional & Single-use

Trends in biopharmaceutical production and bioprocessing mean that pharmaceutical manufacturers require both flexibility and consistency in their R&D, scale-up and production processes. Analytics play a key role in optimizing yield during scale up, whether in conventional, rigid wall bioreactors or in single-use bags.

pH Theory Guide

The control and measurement of pH is vital in a wide range of processes across the pharmaceutical, chemical, and food & beverage industries. But what exactly is pH, why is it so important, and how do pH sensors work

Process Analytics Product Catalog

The METTLER TOLEDO Process Analytics Catalog provides a comprehensive overview of solutions for analytical measurements in liquid process applications, pure water monitoring and gas-phase measurement.

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We support and service your measurement equipment through its entire life-cycle, from installation to preventive maintenance and calibration to equipment repair.

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FAQs

What is a single-use pH sensor?

Single-use pH sensors are sensors for pH measurement that are designed to be integrated into single-use process devices by the device manufacturer.Single-use pH sensors from METTLER TOLEDO measure pH with a potentiometric single-use sensor which has been factory calibrated by METTLER TOLEDO in common buffer solutions (zero point and slope). These disposable pH sensors can be used in a broad range of applications that require single-use bags including cell culture, harvesting, fermentation, media/buffer preparation, virus inactivation and purification steps. With their robust design for enhanced protection, METTLER TOLEDO single-use pH probes ensure a significantly longer shelf life while offering an output signal identical to that of a reusable sensor for highly efficient integration. All wetted polymer materials are made of USP 88 VI certified materials.

What is the shelf life of a single-use pH sensor?

The shelf life of a METTLER TOLEDO single-use pH sensor is up to 30 months. This long shelf life makes inventory management easier for both process device manufacturers and end users.

Can I replace a single-use pH sensor?

Single-use pH sensors are directly integrated into the single-use process device by the device supplier and cannot be taken out and replaced. The complete SUB assembly with the single-use pH sensor is gamma irradiated and is shipped pre-sterilized to the biopharmaceutical producer. Consequently, integrated single-use pH sensors will never be removed from the reactor, will never be autoclaved, and will never be calibrated outside the single-use bioreactor with buffer solutions.

What METTLER TOLEDO single-use pH sensors are available?

The InSUS 310 by METTLER TOLEDO is a single-use pH sensor designed for integration into single-use bioprocess devices. This single-use pH probe has been factory calibrated by the sensor manufacturer in common buffer solutions (zero point and slope) to provide the most reliable pH measurements. The shelf life is 30 months dry storage and the disposable pH sensor is made of USP 88 VI certified materials to ensure the highest process safety.

How do I get a METTLER TOLEDO single-use sensor in my bioreactor bags?

METTLER TOLEDO sells single-use sensors directly to bioprocess equipment manufacturers for integration into their single-use devices. If you are interested in single-use pH sensors or single-use dissolved oxygen sensors for your manufacturing operation, contact your bioprocess device manufacturer and ask them for METTLER TOLEDO InSUS single-use sensors.

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