Raman Spectrometers

Introducing the compact, high-performance ReactRaman Raman Spectrometer, coupled with iC Raman 7 and trusted service and support, provides critical insight – even for the most challenging reactions. ReactRaman is ideal for:

• Multiphasic Reactions
• Crystallization
• Polymorphism Detection

One Click Analytics (only available in iC Raman 7) means that whether you are an expert, or new to Raman Spectrometers, data collection and analysis is fast and accurate.    

ReactRaman Raman Spectrometer combines best-in-class performance with a flexible and portable design; delivering outstanding results wherever it’s needed - on the bench, in the fume hood, or in the lab next door.

Designed specifically for time-resolved reaction analysis, iC Raman software combines a peak picking algorithm with functional group intelligence to drastically reduce analysis time. Users combine knowledge of their chemistry with an automated data analysis workflow to ensure correct interpretation for every experiment.

Raman spectrometer probe- and flow-based sampling technologies are optimized for crystallization and polymorph chemistry investigation. Fit-for-purpose materials of construction make data collection straightforward in acidic and corrosive environments across a wide range of temperatures and pressures.

Raman spectrometers provide complimentary, but different, information to FTIR. While FTIR gives users functional group information, Raman provides backbone and structural information. When combined with FTIR, the user can obtain key information regardless of the sample physical state, giving its user a full picture of their reaction. 

As a company, METTLER TOLEDO has over 30 years of dedicated reaction analysis experience. This is our focus and our passion. For our Raman spectrometer, this is revealed in the details. Our probes and instrumentation have been optimized for detection. Our software was configured to guide the users through collection and analysis steps for results confidence.  Our trusted service and support teams ensure success for the scientist. 

In order to understand chemical reactions, chemists must address the following:

• When does the reaction start? When does the reaction stop?
• What polymorph is being produced?
• What are the reaction kinetics, mechanism, or crystallization process?
• Did it react as expected? Did any by products form, and why?
• What happens if reaction temperature, dosing rates, or mixing rates change?

Traditionally, to obtain reaction information, samples are taken for offline analysis using HPLC.  For chemistries in which sample removal results in the loss of key information, or are toxic or otherwise hazardous, this procedure is not straightforward.  Furthermore, chemists must be present to take the sample and then wait for the results before reaction analysis can begin.

With inline Raman Spectrometers, continuous monitoring allows users to trend components over time for a 'molecular video' of the reaction - making it easy to answer critical questions for reaction and process optimization. 

Reveal Reaction Mechanisms
In this example, ReactRaman Raman Spectrometer follows the conversion of Carbamazepine anhydrate to the dihydrate form while showing the full conversion time

Provide Insight Into Distinguishing Polymorphs
At times, polymorphs can not be identified visibly. ReactRaman provides molecular information to help the user understand more from their crystallization processes

Track Reaction Progress for Better Yield & Purity
Determination of optimal reaction or crystallization endpoint

Measure Form Stability
Conversion of polymorphs can be monitored providing insight into stability of products

Quickly Determine Kinetics
First order reaction kinetics in one experiment

ReactRaman Spectrometer works in a wide range of chemistries in which the molecule is Raman active, the chemistry is in solution, multiphasic or solids, and the concentration is higher than ~0.1 %. 

Common Raman Spectroscopy applications include:

• Crystallization Processes
• Polymorphism Identification
• Polymerization Reactions
• Hydrogenation Reactions
• Chemical Synthesis
• Biocatalysis and Enzymatic Catalysis
• Flow Chemistry
• Bioprocess Monitoring
• Synthesis Reactions

Check out our Raman Spectroscopy resource page for information, including:

• What is Raman Spectroscopy?
• The Principles of Raman Spectroscopy
• How Does Raman Spectroscopy Work?
• The Raman Scattering Process
• Raman vs. FTIR Spectroscopy

Below is a selection of publications featuring raman spectrometers.

Shihao Zhang, Ling Zhou, Wenchao Yang, Chuang Xie, Zhao Wang, Baohong Hou, Hongxun Hao, Lina Zhou, Ying Bao, Qiuxiang Yin; An Investigation into the Morphology Evolution of Ethyl Vanillin with the Presence of a Polymer Additive  Cryst. Growth Des. 2020

Jiayu Dai, Lihong Jia, Wenchao Yang, Dan Zhu, Chuang Xie, Ying Bao, Ling Zhou, Qiuxiang Yin Solid Forms Selection of Spironolactone Ternary Phase Diagram and Nucleation Process  Ind. Eng. Chem. Res 2020,59,3,1350-1361

ReactRaman Raman Spectrometer is part of an integrated family of products, which includes:

• ReactIR
• EasyViewer to view and measure particles in situ and in real time
• EasyMax, OptiMax, and RX-10 Chemical Synthesis Reactors
• EasySampler

Designed specifically for chemical and process development, these tools are combined with the iC software platform to provide comprehensive process understanding and control.