Your analytical instruments are the centerpiece of your quality system. How can you ensure that you measure reliably to ensure product quality and avoid the costs of inaccurate results? And how can you meet regulatory requirements and all internal and external standards?
METTLER TOLEDO's calibration and verification services document how accurate your measurement equipment is and if it is accurate enough for your specific needs.
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Calibration, Verification, and Certification for Analytical Instruments
Benefits of Analytical Instruments Calibration and Verification
Compliance with Regulations and Standards
Fully Traceable and Audit-Ready Certificates
Accurate and Reliable Results
Certified Reference Materials
Globally-Harmonized Procedures
Calibration Offerings That Cover All Your Needs
The required calibration and verification service depends on the equipment type, your industry, the laws and regulations, as well as your applications and usage of the instrument.
METTLER TOLEDO will help you determine the optimal frequency of calibration and verification based on your individual conditions.
Titration Calibration and Performance Verification
The accuracy of your titration equipment becomes less reliable over time due to wear and tear of the electronics and mechanical parts. Therefore, regular calibration is essential to ensure consistent equipment performance and adherence to technical specifications, which builds the basis of accurate and reliable titration results. Calibration of all sensor inputs, digital sensors, and burette drive stroke length using certified reference tools ensures performance and makes sure that your titrator is working according to its specifications.
The burette volume is calibrated individually in accordance with ISO 8655 Part 3 to ensure truly interchangeable burettes.
Calibration services are available for:
Excellence Titrators T5, T7, and T9
Compact Titrators G10S, G20S
Volumetric Karl Fischer Titrators V10S, V20S, and V30S
Coulometric Karl Fischer Titrators C10S, C20S, and C30S
Karl Fischer Oven Autosamplers InMotion KF Flex, Pro
Advanced Volumetric Karl Fischer Titrators EVA V1, EVA V3
dDrive and DispenSix Liquid Handler
Titration Calibration and Preventive Maintenance
Calibration Activities
Calibration of all sensor inputs or digital sensors
Calibration of burette drive stroke length
Using certified reference tools
Yielding clear pass/fail statement
As found/as left if applicable
Documented proof of titrator performance
Compliance to applicable regulations and guidelines
The dedicated GSST service is an additional service to complement preventive maintenance and calibration. It's a lifecycle service that verifies the performance of the complete titration system on a regular basis, available for METTLER TOLEDO general and Karl Fischer Titrators including the InMotion™ Oven Autosampler.
Performance verification is the recommended workflow to confirm the faultless routine operation of the titrator and secure result reliability.
The VPac Performance Verification is available for EasyPlus™ Titrators. It combines the convenience of already-made standard kits and an online verification service.
Density and Refractometry Calibration and Performance Verification
Running your density meter or refractometer at its highest accuracy requires calibration with certified reference standards on a regular basis. This allows verification of your adjustment parameters, ensuring highly reliable results over the entire lifetime of your instrument. External influences, inadequate handling of the instrument, or aging of the measuring cell might make an adjustment of the instrument necessary. If the calibration measurements are out of specification, a re-adjustment is performed to guarantee accurate results for future measurements.
For routine performance verification, combined certified reference standards from METTLER TOLEDO are available for Excellence Density Meters and Refractometers as well as portable meters.
Melting and Dropping Point Calibration and Performance Verification
In order to guarantee the most accurate melting or dropping point measurements of your samples, regular temperature verification and calibration of your instrument is required. Our calibration service uses certified reference standards for calibration and adjustment if necessary (as found/as left).
For the MP80 instrument, which allows boiling point determination, the built-in pressure sensor is calibrated using a certified reference sensor.
The unbiased and fully traceable calibration certificate enables regulatory compliance and audit readiness.
METTLER TOLEDO reference standards allow accurate temperature verification of any melting and dropping point instrument during routine operation. Each high-purity reference substance comes with certified temperature values for thermodynamic and pharmacopeia modes. Reference standards are available in a range from 40 – 360 ͦ C.
Calibration services are available for:
Melting Point Excellence MP30, MP55, MP70, MP80 and MP90
Dropping Point Excellence DP70 and DP90
Calibration Activities:
Temperature calibration and adjustment (if required)
Make sure your instrument is within specification and continues to be fit for purpose. Our calibration services use bespoke certified reference tools, specially designed to meet USP or Ph. Eur. requirements. *
CertiRef™ and LinSet™ performance verification modules offer a fast and secure solution for the calibration of UV/VIS Excellence Spectrophotometers. The plug-and-play modules equipped with certified reference materials (CRMs) run fully automated and provide full traceability of all test results, enabling regulatory compliance and audit readiness.
Calibration services are available for:
Excellence Spectrophotometers UV5, UV5 Bio, UV5 Nano and UV7
EasyPlus Spectrophotometers Easy Vis, Easy UV
* Only UV7 Excellence guarantees compliance with Pharmacopoeia
Calibration Activities
Photometric accuracy, repeatability, and linearity (UV and Vis)
pH Meters Calibration, Verification, and Certification
pH, conductivity, ion, ORP, and dissolved oxygen
Calibration ensures the optimal performance of your pH and conductivity meters. With our professionally trained technicians and certified tools, we deliver reliable pass/fail statements and comprehensive calibration certificates, providing documented proof of meter performance.
This service ensures compliance with local and global regulations, such as GLP, USP/EP, and DIN, and helps you avoid the costs associated with inaccurate measurements, ultimately safeguarding quality and supporting your internal standards.
Learn how to perform compliant and accurate density and refractive index measurements in the pharmac...
FAQs
How frequently do I need calibration services?
The calibration interval strongly depends on the individual application, frequency of use, and environmental conditions. Typically, the frequency is determined based on a risk assessment of the entire process where the equipment is used.
While METTLER TOLEDO provides recommendations, ultimately it is the user's responsibility to determine the frequency of maintenance and calibration required for their process.
Is calibration performed onsite, or are the devices sent to a depot/calibration lab?
Primarily, calibration should be performed onsite to consider performance under actual ambient/user conditions.
However, for some equipment (e.g.: titration burettes, portable instruments), depot calibration is available. Availability also depends on the local METTLER TOLEDO service setup/infrastructure.
What is titration calibration?
Titration calibration is basically the verification of the technical specification of a titrator. For example, the burette drive stroke length significantly impacts the dosing accuracy, which is crucial to achieving accurate and reliable titration results. We use a certified micrometer and measure the stroke length at different levels (in accordance with ISO 8655) to ensure dosing accuracy over the entire dispensing range/burette volume. The burette volume is calibrated separately, according to ISO 8655 part 3, to ensure truly interchangeable burettes.
The accuracy of the sensor input is indispensable for proper potential measurements (e.g., mV/pH) to monitor the titration reaction and the correct EP/EQP evaluation. For calibration, we are using certified resistors and digital multimeter to ensure measurements are within specifications.
For the InMotion™ KF Oven Autosampler, the oven temperature accuracy and stability and gas flow rate are calibrated using a certified temperature sensor and gas flow meter.
The certificate includes a clear pass/fail decision based on maximum permissible errors from technical specifications and provides full traceability of all measurement results and tools used for calibration.
What is the difference between adjustment and calibration for density and refractometry?
The adjustment builds the relationship between the measured signal/value and the result unit. This is the oscillation frequency for density measurements and the critical angle of total reflection for the refractive index, respectively. To be able to measure proper density or refractive index values, the corresponding measurement cells need to be adjusted using known samples/reference standards, i.e., water and/or air.
A calibration is performed using certified reference standards and establishes the difference between the actual measured value and the certified value of the reference standard. If the measured value is within the tolerances, calibration is passed. If the measured value is outside the tolerances, we recommend thoroughly cleaning and drying the measurement cell and then recalibrating, it before doing a re-adjustment of the measuring cell.
Our instruments are delivered with a factory adjustment, except for Excellence and Portable Refractometers.
Can METTLER TOLEDO calibrate my UV/Vis spectrophotometer to comply with both pharmacopeias, Ph. Eur. and USP?
Yes, it’s possible to calibrate the UV/Vis Spectrophotometer to be compliant with both pharmacopeias.
The main difference between USP and Ph. Eur. is related to stray light determination. There are two different procedures for stray light determination, i.e.:
Procedure A: Solution Filter Ratio Method (SFRM)
Procedure B: Specific Wavelength method (SWM)
While USP accepts both procedures, Ph. Eur. only accepts procedure B.
Using the CertiRef EUP enables performance verification and calibration for compliance with both pharmacopeias. For photometric linearity, either LinSet PDC or LinSet Niacin can be used for compliance with USP and Ph. Eur.
Please note that only UV7 Excellence complies with pharmacopeias.
Which standard(s) can I use for dropping point performance verification and calibration/adjustment?
METTLER TOLEDO reference substances, such as benzophenone, vanillin, benzoic acid, and potassium nitrate, provide temperature values that can be used for the temperature calibration of dropping point instruments.
Caffeine and saccharine cannot be used as they do not drop properly.
The basis for comparison is the thermodynamic melting point of the calibration substance that is detailed on the corresponding certificate. However, the dropping point of a reference substance is not equal to the thermodynamic melting point as it refers to the furnace temperature but not the sample temperature. Therefore, the temperature needs to be adjusted using a substance-specific correction factor.
The DP70 and DP90 Excellence instruments include an automatic procedure/method for temperature verification, and correction factors for each reference substance are stored in the instrument.