Crystallization Scale-up Strategy Development
Crystallization Process Design to Ensure Successful Scale-Up
프로그램
- Crystallization Scale-up Overview
- Mixing Implications and Criteria for Crystallization Processes
- Classical Engineering Calculations Approach
- Case Study 1: Classical cooling crystallization whereby a process is delivering variable PSD at both lab and plant scale reactors. Requirement to identify the most suitable scale-up criteria for improved process robustness.
- Case Study 2: pH-adjusted crystallization whereby HCI.IPA was added to a solution of freebase in IPA over a three stage addition profile. Variable output PSD. Evidence of undesired form precipitating prior to form conversion over a short time scale.
본 웹 세미나에서는 유체 역학과 결정화 속도 사이의 상호 작용을 이해하고 관리하는 방법을 설명하기위한 두 가지 연구 사례에 대해 배워 봅니다.
About the Presenter
Damian Duffy
APC Ltd., Dublin, Ireland
Damian Duffy is a team lead in small molecule process development at APC Ltd in Dublin, Ireland where he has been working on crystallization/organic process research and development, continuous crystallization and process modelling. Having obtained a degree in Chemical Engineering from University College Dublin (UCD), he went on to earn a PhD in Control of Crystallization Processes under Professor Brian Glennon at UCD. He has publications on crystallization control and significant interest in crystallization process scale-up using Process Analytical Technology (PAT) and modeling.
