Taking cell cultures of pharmaceutical water has long been the most common and accepted practice for measuring microbial contamination. While accurate when done correctly, the process of lab testing pharmaceutical water requires a significant time delay before acquiring measurement results. This, along with the possibility of mishandled samples, leaves room for error or contamination in your water. This white paper explores an accepted, alternate technology for at-line, real-time microbial contamination monitoring.

TOC Analyzer and Microbial Detection Analyzer FAQs
Microbial Detection Analyzer 7000RMS | On-Line TOC Analyzer | Portable TOC Analyzers |
The 7000RMS analyzer delivers instant, real-time monitoring of microbial contamination to increase process control and minimize the risk of releasing contaminated water. | On-line TOC analyzers offer uninterrupted monitoring of total organic carbon levels for a range of water purity levels. With real-time results, continuous TOC analyzers allow for immediate, preventati... | Proven, continuous measurement technology provides the fastest response time in a portable TOC analyzer. A valuable and convenient tool for water system diagnostics. |
Improve process control and production efficiency Control product quality with highly sensitive technology Minimize sampling errors and reduce costs Rapid response to contamination events Optimize sanitization frequency and effectiveness | Never miss an excursion with real-time measurement Ensure compliance with global pharmacopeias Monitor and record TOC levels for audit compliance Versatile detection from ppm to sub-ppb levels Easy-to-maintain with no moving parts or solutions | Reduce Sampling Time by 75% Easy Data Capture and Analysis via USB Compliant with Global Pharmacopeias |
TOC Pump Module | ||
Provides a highly stable, metered flow of process water to the TOC sensor to ensure reliable and consistent TOC measurement performance. | ||
For applications where system pressure is too low to provide adequate flow through the TOC sensor For low-pressure applications where system pressure may vary routinely during operation |
The 7000RMS analyzer delivers instant, real-time monitoring of microbial contamination to increase process control and minimize the risk of releasing contaminated water.
On-line TOC analyzers offer uninterrupted monitoring of total organic carbon levels for a range of water purity levels. With real-time results, continuous TOC analyzers allow for immediate, preventati...
Proven, continuous measurement technology provides the fastest response time in a portable TOC analyzer. A valuable and convenient tool for water system diagnostics.
Provides a highly stable, metered flow of process water to the TOC sensor to ensure reliable and consistent TOC measurement performance.
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Don't Miss a Bug with Real-Time Microbial Monitoring

Pharmaceutical Waters Guide
This free 40-page guide on regulatory compliance, analysis and real-time release of pharmaceutical waters covers a wide variety of topics relevant to those involved in pharmaceutical water management. The guide covers process analytical technology (PAT) and Intelligent Sensor Management (ISM), and focuses on providing knowledge and case studies related to total organic carbon (TOC), conductivity and resistivity, and ozone measurement.

Process Analytics Product Catalog
The Process Analytics catalog includes product features and specifications, benefits and recommended application areas for the wide range of parameters which METTLER TOLEDO measures including: pH/ORP, Conductivity, Turbidity, Dissolved Oxygen, Dissolved Carbon Dioxide, Gas Analytics, Total Organic Carbon, Sodium, Silica, and Microbial Contamination. It also highlights the transmitters and housing that are needed to make an entire measurement system.
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We support and service your measurement equipment through its entire life-cycle, from installation to preventive maintenance and calibration to equipment repair.
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Confidence in Regulatory Compliance with TOC
Continuous on-line monitoring of total organic carbon in pharmaceutical water systems helps operators to maintain the integrity of their water systems to meet quality objectives and regulatory compliance with global Pharmacopeia standards. This video highlights the benefits that can be achieved by integrating the Thornton 5000TOCi on-line TOC sensor with ISM technology. Predictive diagnostics, high responsiveness and record-keeping enhancements make this solution part of comprehensive pure water measuring system.