Aluminum Phosphate Vaccine Adjuvant: Composition and Size Analysis
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Aluminum Phosphate Vaccine Adjuvant: Composition and Size Analysis

Using Offline and Inline Tools

Interaction between antigen and adjuvant or adsorption of antigen to adjuvant is critical for the effective adsorption. Particle size distribution of aluminum phosphate and adsorbed protein were examined by laser diffraction and Focused Beam Reflectance Measurement (FBRM) at line and inline respectively. Compositional analysis of aluminum phosphate was performed at line using FTIR and Raman Spectroscopy, and inline ATR probe were used to examine adsorbed protein suspension. 

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Marina Kirkitadze, Ph.D, MBA has 17 year experience with Sanofi Pasteur, the vaccine division of Sanofi group. She is the Head of Analytical Process Support and PAT Platform, Analytical Sciences Toronto. Marina's main focus is characterization of vaccine components, specifically, protein conformation and stability in solution and in adjuvanted form, analysis of raw materials, particle sizing technologies, and inline PAT applications. Her contributions went towards CMC section in eBLA application for Adacel, new manufacturing facility submission, Pentacel, and to Module 3 CTD of Hexaxim vaccine submission. Marina has published 36 manuscripts.