Scale-Up of Anti-Solvent Addition Crystallizations

Optimization and Scale-up of Anti-solvent Addition Crystallizations from Lab to Pilot Plant

The webinar focuses on a semi-quantitative method for the optimization and scale-up of hydrodynamically limited anti-solvent crystallization process. This protocol combines in situ Process Analytical Technologies (PAT) with Computational Fluid Dynamics (CFD) to facilitate the production of a knowledge based scale-up strategy for this mixing limited crystallization process.

Moderator: Mark Barrett - APC (The Applied Process Company)

Duration: 38 Minutes

Language: English

Certain attributes of turbulent mixing have been identified to impact key crystallization characteristics, including:

Metastable Zone Width (MSZW)
Primary and Secondary Nucleation Events
Growth and Agglomeration Rates

Scale-Up of Anti-Solvent Addition Crystallizations

Guest Presenter Mark Barrett

This presentation focuses on the use of Process Analytical Technology (PAT) and Computational Fluid Dynamics (CFD) in understanding common industrial crystallization challenges and in turn facilitate the production of methods for the scale-up and scale-down of this process. A "scale-up toolbox" is used to optimize bench scale crystallizations to produce efficient, repeatable crystallizations. Three case studies are included:

Case Study 1: Impact of Turbulent Mixing on Crystallization
Case Study 2: Overcoming Poor Anti-Solvent Addition Points
Case Study 3: Developing an Optimal Anti-Solvent Addition Profile

Guest Presenter
Mark Barrett received his Ph.D. in Chemical Engineering from University College Dublin (UCD). His thesis work focused on crystallization development and scale-up. Prior to co-founding APC in 2011, Mark worked for Solid State Pharmaceutical Cluster (SSPC) and Schering Plough.