Detection of Residual Solvents in a Pharmaceutical Substance by TGA-MS - METTLER TOLEDO

Detection of Residual Solvents in a Pharmaceutical Substance by TGA-MS

Introduction

In production processes, active pharmaceutical ingredients (APIs) are often recrystallized from different solvents in order to obtain the desired crystalline form. Afterward, it is important to check that no unwanted solvent residues are left in the API. In this example, a TGA coupled to a mass spectrometer was used to detect methanol and acetone residues in an active pharmaceutical substance.

Sample:                 Pharmaceutically active substance

Measuring cell:     TGA-MS

Detection of Residual Solvents
Detection of Residual Solvents

Detection of Residual Solvents in a Pharmaceutical Substance by TGA-MS | Thermal Analysis Handbook No.HB606 | Application published in METTLER TOLEDO TA Application Handbook Evolved Gas Analysis