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In Situ FTIR Spectroscopy for Lab and Process
ReactIR in situ Fourier Transform Infrared (FTIR) spectroscopy delivers the performance, sampling versatility and intuitive reaction analysis software for information and understanding about chemistry. ReactIR in situ FTIR Spectroscopy provides real-time reaction monitoring in both lab and process environments. Attenuated Total Reflection (ATR) provides data about conversion, intermediates, reaction initiation, and endpoint.
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In many instances, reaction understanding requires the construction of accurate reaction profiles for each species that are expressed as concentration versus time, leading to the determination of reaction kinetics. In Situ Mid-Infrared ATR-FTIR Spectroscopy is an ideal technique to provide this information, as it allows the rapid collection of detailed reaction profiles.
Mid-Infrared ATR-FTIR Spectroscopy brings a couple of advantages to reaction analysis. First, the use of the fingerprint region of the mid-infrared enables the individual tracking of chemical species, which in turn provides clues to the mechanism of the reaction. Second, Beer's Law gives the connection between the measured absorbance of the reaction species and its concentration. This relationship means we can use an offline measurement to determine the concentration of an offline sample, and then use that data point to scale the mid-infrared profile. There is a correlation between the concentration measurement of offline samples and the measured shape of the in situ samples.
Mid-infrared attenuated total reflectance (ATR) technology offers numerous advantages over alternative analytical methods, including other molecular spectroscopy techniques. Researchers and scientists improve chemical development by leveraging these advantages, including:
Instantaneous information can be gained about a reaction from ReactIR FTIR spectroscopy because it is an in situ technique. This is a key benefit to obtaining further insights into reaction behavior, particularly where transient species are involved.
The reason why the data is so important is because of its continuous nature. With ReactIR FTIR Spectroscopy, data collection is automated, typically generating concentration information every minute, even as fast as four times every second. This means that rather than running a large number of reactions to understand rate dependencies, just a few experiments can provide the necessary information to determine the driving forces of a reaction supporting reaction mechanistic theory. This means that research can progress at an accelerated rate. In addition, the data is often more accurate than data analyzed by offline techniques as there is no possible alteration of the molecules by preparation for analysis, or by exposing it to an enviroment other than that within the reaction vessel.
ReactIR FTIR Spectroscopy is used in the pharmaceutical, chemical, and petrochemical industries as well as in academic research.