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Collection

Process Analytical Technology Webinars

Collection

Resources for Process Analytical Technology (PAT) and Quality by Design

In the spirit of sharing best practices and novel applications, please find a curated collection of our most popular presentations from past events for you to view at your leisure.

Industry experts share best practices and case studies on the control and optimization of:

  • Automation and Digitalization
  • Process Development and Scale-up
  • Continuous Flow Chemistry
  • Crystallization
  • Bioprocessing
Continuous Flow Chemistry
continuous flow chemistry for api manufacturing
Continuous Flow Chemistry for API Manufacturing
Presented by Dr. Frederic Buono of Boehringer-Ingelheim, this on-demand webinar reviews continuous flow process development, including general concept...
Accelerated Process Development
Accelerated Process Development
Process development focused on continuous processes can utilize many of the same tools used in traditional batch processes. Nalas Engineering develops...
Continuous Primary Processing Facilitated by PAT
Continuous Primary Processing Facilitated by PAT
In this highly informative session, our esteemed experts in the fields of continuous flow chemistry, PAT, and chemical synthesis will guide you throug...
Accelerate Process Development with Flow Technologies
Accelerate Process Development with Flow Technologies
Grace Russell, PhD of Snapdragon Chemistry presents a scalable, purified diazomethane production and consumption that leverages continuous flow techno...
End Game: Technology Development for Continuous Isolation
End Game: Technology Development for Continuous Isolation
Daniel Ward of Nalas Engineering presents two examples where continuous processing has been implemented. These processes are integrated with continuou...
Webinar: Organolithium Compounds in Organic Synthesis
organolithium compounds in organic synthesis
Prof. Aiichiro Nagaki of Kyoto University discusses an approach to various synthetic reactions mediated by organolithium reagents based on flash chemi...
Webinar: Enhance Process Development in Flow Leveraging Inline DRE and Automation
Webinar: Enhance Process Development in Flow Leveraging Inline DRE and Automation
Brian M. Wyvratt of Merck presents "Enhance Process Development in Flow Leveraging Inline DRE and Automation".
Crystallization
Optimization of a Crystallization Process
Optimization of a Crystallization Process at Roche
Martin Betschart presents how Roche Pharmaceuticals optimizes a crystallization process. Details of the optimization of the cooling rate and of the s...
Liquid-Liquid Phase Separation in Crystallization
Liquid-Liquid Phase Separation in Crystallization
Design and develop robust, scalable crystallization processes that avoids Liquid-Liquid Phase Separation (LLPS) or oiling out.
Pharmaceutical Drug Substance Crystallization
Pharmaceutical Drug Substance Crystallization
This presentation describes the case of crystals of an Active Pharmaceutical Ingredient (API) with high propensity to float in their mother liquors, d...
Modeling & Feedback Control of Batch & Continuous Crystallization Systems
Modeling & Feedback Control of Batch & Continuous Crystallization Systems
During this presentation, Professor Zoltan Nagy of Purdue University gives an overview of recent advances in quantitative monitoring and feedback cont...
Investigating a Complex Polymorph and Pseudo-Polymorph Landscape
Investigating a Complex Polymorph and Pseudo-Polymorph Landscape
This webinar discusses the applicability of in-situ Raman in order to understand formation pathways of desired and undesired polymorphs as well as pos...
Monitoring and Detection of Byproduct Crystallization
Reactive Crystallization of Beta-Lactam Antibiotics
Matthew McDonald of GA Tech describes a system that involves the reactive crystallization of beta-lactam antibiotics, wherein a byproduct of the enzym...
Implementation of Continuous Crystallization to Circumvent Metastable Liquid-Liquid Separation
Implementation of Continuous Crystallization to Circumvent Metastable Liquid-Liquid Separation
Continuous crystallization provides an alternative to traditional batch crystallization, where the product endpoint is locked into a more predictable...
Rapid Process Design of Agrochemical Crystallization
Design of Agrochemical Crystallization
Wei-Lee Wu of Purdue University presents the "Utilization of Quality by Control for Rapid Process Design of Agrochemical Crystallization"
Two Approaches to Effective Particle Size and Impurity Control
Two Approaches to Effective Particle Size and Impurity Control
Scott Quirie of Merck & Co., Inc. presents "Two Approaches to Effective Particle Size and Impurity Control".
Incorporating Computer Vision Into Crystallization Workflows
Incorporating Computer Vision Into Crystallization Workflows
This presentation discusses the use of HeinSight (a modular vision package) to support the deployment of intelligent automation in chemical discovery.
Mapping Solvate Behavior of an API Intermediate
Mapping Solvate Behavior of an API Intermediate
Eric Standley of Gilead Sciences, Inc. presents "Mapping Solvate Behavior of an API Intermediate".
Process Development and Scale-up
Multi-Scale PAT for Small Molecule Development
Multi-Scale PAT for Small Molecule Development
Zachary Dance of Merck & Co., Inc. describes leveraging multi-scale PAT capabilities to enhance small molecule development.
Process Development and Kinetic Understanding
Process Development and Kinetic Understanding
Presented by Eric Moschetta, this on-demand webinar describes how AbbVie built a robust kinetic model to understand a late-stage API process
Impact of Process Intensification on Process Safety
Impact of Process Intensification on Process Safety
This presentation discusses how Nalas Engineering safely handles high energy materials and hazardous chemistry.
Challenges in Process Safety Assurance of a Hazardous Epoxidation
Challenges in Process Safety Assurance of a Hazardous Epoxidation
This case study summarizes the retrospective process to assure safety of an energetic epoxidation process following regulatory intervention action.
Phase Separation in Polymer Solutions and Gels
Analysis of Polymer Separations
Mary Alice Upshur of Dow Chemical Co. presents "Online Mid-IR and Raman Spectroscopy: Enhanced Compositional Analysis of Polymer Separations".
In-situ Monitoring of Acrylonitrile Addition
Acrylonitrile Addition
Matt Meredith of Huntsman Corporation presents "In-situ Monitoring of Acrylonitrile Addition with Mid-IR to Improve Process and Product Quality".
Data-Rich Experimentation Across Scale
Data-Rich Experimentation Across Scale
Keith Mattern, Merck & Co., Inc., presents "Data-Rich Experimentation Across Scale: Leveraging PAT and Reactor Automation for Robust Process Design".
Development of a Semi-Continuous Manufacturing Process
Development of a Semi-Continuous Manufacturing Process
Ronald Carrasquillo of Bristol-Myers Squibb presents " PAT Enabled Development of a Semi-Continuous Drug Substance Manufacturing Process".
Continuous Safety Improvements to Avoid Runaway Reactions
Continuous Safety Improvements to Avoid Runaway Reactions
Alessandro Agosti, Olon S.p.A., presents "Continuous Safety Improvements to Avoid Runaway Reactions".
The Power of PAT at Scale in an API Pilot Plant
The Power of PAT at Scale in an API Pilot Plant
James Marek and Eric Moschetta of AbbVie present "The Power of PAT at Scale in an API Pilot Plant".
The Changing Role of PAT in Scale-up
The Changing Role of PAT in Scale-up
Jan Dijkmans of Janssen presents "The Changing Role of PAT From Process Development to Commercialization and Bridging the Gaps Between Them".
Democratizing PAT to Enable Kinetic Analysis and Modeling
Democratizing PAT to Enable Kinetic Analysis and Modeling
James Murray of Amgen presents "Democratizing PAT to Enable Kinetic Analysis and Modeling".
Kinetic Modeling of Chemical Reactions
Kinetic Modeling of Chemical Reactions
By quantitatively describing the reaction kinetics, kinetic models provide valuable insights into the reaction mechanism, reaction pathways, and the i...
In-situ IR Study of Thermoplastic Polyurethane (TPU) Reactions
In-situ IR Study of Thermoplastic Polyurethane (TPU) Reactions
Xianghuai (William) Wang of Lubrizol Advanced Materials presents "In-Situ IR Study on Polyurethane Reactions".
Insights into Reaction Pathways of Taurine Synthesis from Ethanolamine
Insights into Reaction Pathways of Taurine Synthesis from Ethanolamine
Veronica Milligan of ADM Process Chemistry & Catalysis presents "Insights into Reaction Pathways of Taurine Synthesis from Ethanolamine".
Bioprocessing
Aluminum Adjuvant Chemistry
Inline vs Offline PAT
This presentation discusses how Sanofi Pasteur established bioprocess characterization by evaluating inline and offline analytical techniques. Scienti...
Real-Time Monitoring of Downstream Biologics Operations
Real-Time Monitoring of Downstream Biologics Operations
Greg Lane of Bristol Myers Squibb reviews the use of in-situ monitoring PAT to characterize and optimize processes faster and with less effort.
Process Characterization for Low pH Virus Inactivation
Process Characterization for Low pH Virus Inactivation
The Low-pH treatment for virus inactivation unit operation presents a potential risk for in-process product aggregation during downstream processing f...
Aluminum Phosphate Vaccine Adjuvants
Aluminum Phosphate Vaccine Adjuvant
Interaction between antigen and adjuvant or adsorption of antigen to adjuvant is critical for effective adsorption. Particle size distribution of alum...
Viral Inactivation in Bioprocess Development
Viral Inactivation in Bioprocess Development
Automating low pH viral inactivation process development accelerates project timelines and reduces costs. Now, scientists can capture the same quantit...
Real-Time Oligonucleotide Sequence Confirmation
Oligonucleotide Sequence Confirmation
This presentation shares Biogen’s experience utilizing automated, online PAT for real-time oligonucleotide sequence confirmation.
PAT for the Future of Oligonucleotide Manufacturing
Oligonucleotide Sequence Confirmation
Dr. Karsten Keller of Nitto Denko Avecia presents "PAT for the Future of Oligonucleotide Manufacturing".
Monitoring Virus Aggregates and Drug Substance Concentrations in a TFF Process
Monitoring Virus Aggregates and Drug Substance Concentrations in a TFF Process
Thomas Linke describes how AstraZeneca immediately identifies agglomeration mechanisms during a Tangential Flow Filtration (TFF) process.
Developing Robust and Scale-able Peptide Isolation Processes
Developing Robust and Scale-able Peptide Isolation Processes
Emily Guinn and Kyle Blakely, Eli Lily present "Developing Robust and Scale-able Peptide Precipitation Processes".
Measurement of Surfactant Concentration in Viral Vaccine Downstream Processing
Measurement of Surfactant Concentration in Viral Vaccine Downstream Processing
Marina Kirkitadze of Sanofi Pasteur presents "Measurement of Surfactant Concentration in Viral Vaccine Downstream Processing".