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This page details multiparameter analysis of chiral compounds, measuring optical rotation via polarimetry, along with density/specific gravity and refractive index to verify its identity and purity. By downloading the application note you will receive the PDF of the application note |
The term "chirality" originates from the Greek word "kheir," which means hand. Molecules that are chiral cannot be superimposed on their mirror images. Chirality is an important concept in many areas, especially pharmaceuticals as different molecular forms can lead to either positive or negative therapeutic effects.
What is optical rotation?
Optical rotation is the phenomena where polarized light changes its direction as it moves through certain substances, often those containing chiral molecules. This concept is used to identify substances, determine their concentration, and examine molecular structures in fields like pharmaceuticals, flavor and fragrances, food and beverages etc.
How to determine identity and purity of optically active substances?
Measuring a substance's optical rotation through polarimetry, along with determining its density or specific gravity and refractive index, are commonly used methods to evaluate its identity and purity.
Why use multiparameter analysis for analyzing samples?
Multiparameter analysis efficiently and automatically measures multiple properties like optical rotation, density, and refractive index to assess sample identity and purity. It has multiple benefits. As the system is fully automated, it enables operators to focus on other laboratory tasks and allows single reporting, while the autosampler performs automatic filling, cleaning and drying of the measuring cells.
