Dissolved Oxygen Probes for Bioreactors | DO Sensors for Bioreactors

Bioreactor Dissolved Oxygen Sensors

Achieve Optimal DO Control in Cell Culture & Fermentation

METTLER TOLEDO bioreactor DO probes are accurate, reliable dissolved oxygen sensors designed to be used in bioreactors in pharmaceutical manufacturing. These DO sensors for bioreactors offer a stable measurement signal that allows them to be used across a wide range of bioreactor capacities, from R&D-scale bioreactors to commercial manufacturing. These sensors help you to enable ideal growth conditions to maximize yield under microbial and animal cell culture bioprocessing conditions.

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Sensors for Various Bioreactor Capacities & Applications

METTLER TOLEDO DO sensors are ideal for scale-up. The same sensor model can be used in all bioreactor sizes, from benchtop bioreactors to large-scale bioreactors in commercial phase manufacturing.

Easy to Clean for Use Under Sterile Conditions

These sensors withstand all pharmaceutical sterilization and sanitization processes making them ideal for cell culture DO and fermenter DO monitoring and control.

Prevent Signal Noise in DO Sensor Installations

Optical DO sensors with a special OptoCap repel purge bubbles that collect and adhere to the tip of the DO sensor, eliminating the noise caused by purge bubbles and improving DO control.

Maintain Optimal Conditions to Maximize Yield

DO probes fitted into a bioreactor measure dissolved oxygen available in media, while maintaining a defined setpoint to control a fermentation or cell culture process.

For Conventional and Single-Use Bioreactors

These sensors are designed to be used in conventional benchtop, rigid-wall bioreactors or with a single-use housing, autoclaved and aseptically inserted into a single-use bioreactor bag.

Bioreactor DO Probes with ISM Predictive Diagnostics

All digital METTLER TOLEDO DO probes for bioreactors offer ISM technology, which enables the monitoring and management of the sensor's lifetime before sterilization and during a batch.

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FAQs

What are bioreactor dissolved oxygen probes?

Bioreactor dissolved oxygen probes are DO sensors that are uniquely suited for the environment of industrial bioreactors during pharmaceutical manufacturing. These DO sensors for bioreactors provide an accurate, reliable and stable measurement in various sizes of bioreactor, from benchtop bioreactors used in process development to large-scale bioreactors used in commercial manufacturing. These sensors are available in optical and amperometric/polarographic technologies. Selecting the right dissolved oxygen sensor for your bioreactor supports you maintain ideal growth conditions, ensures batch-to-batch consistency and helps to preserve quality attributes in microbial or cell culture environmental process conditions.

What ISM technology features are available in these DO sensors?

Intelligent Sensor Management (ISM) technology offered with METTLER TOLEDO bioreactor DO probes provides a number of useful benefits that analog sensors cannot deliver. ISM predictive diagnostics help you manage the maintenance of your sensors throughout the run of your bioreactor. With the ability to store calibration data directly in the head of the DO sensor, a sensor can quickly be replaced in a process (Plug and Measure) allowing for fast installation and commissioning of a measurement point. ISM DO electrodes used during fermentation or cell culture can identify if a sensor can be safely reused in the next batch, or if it needs to have consumables replaced, maintenance performed or if it needs to be re-calibrated. When integrated with iSense software, ISM provides simpler traceability and reporting for regulatory compliance.

How do I clean my DO probe?

METTLER TOLEDO dissolved oxygen sensors for bioreactors are designed to be cleaned by processes common in pharmaceutical production. These sensors provide reliable measurement after steam-sterilization or autoclave processes. Sensors with Intelligent Sensor Management (ISM) technology also keep track of the number of cleaning cycles that a DO sensor has undergone.

How do I prevent signal noise from oxygenation of the bioreactor?

In a bioreactor, dissolved oxygen sensors are subject to measurement interference because of purge bubbles during oxygenation. The effect is particularly troublesome in vertical sensor installations, but also in large scale fermenters where the probe is installed angular in the side walls. METTLER TOLEDO offers dissolved oxygen sensors specifically designed to prevent this issue. The InPro 6860i HD model is an anti-bubble dissolved oxygen sensor with a mechanically modified hydrophilic surface and tilted design. The angled tip and surface structure are designed to repel air/oxygen bubbles, preventing their accumulation and formation and therefore virtually eliminating DO signal noise in your bioreactor.