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Microbial Detection Analyzer 7000RMS

Real-time Monitoring of Bioburden in Water

An online water bioburden analyzer is a rapid microbial method for measuring microbial contamination in pharmaceutical grade waters. It offers a real-time microbial monitoring solution, providing continuous results every two seconds for better control of your water system. The 7000RMS rapid bioburden analyzer uses advanced, laser-induced fluorescence and Mie scattering technology to provide immediate detection and quantification of microorganisms.

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FAQs

How do I measure microbial contamination of water?

There are numerous ways to measure microbial contamination of water, and USP recommends specific ways of doing so for pharmaceutical waters. Traditionally plate count methods are widely used for releasing water; however, they are prone to error and can take 5-7 days for results. Plate counting also requires the formation of a colony of bacteria on a plate and hence the measurement unit is called 'colony forming unit" or CFU, which is an estimation of the total number of bacteria present in the sample plate. Another way of measuring microbial contamination in water is through laser-induced fluorescence, with a microbial detection analyzer. These analyzers uses laser induced florescent technoly to measure the total number of cells that are present in the sample volume of water. Systems that uses this type of technology allow for at-line, real-time monitoring of microbial contamination in pharmaceutical waters by identifying cells present in the sample water immeditely and is reported as auto fluorescent units (AFUs).

What are auto fluorescent units?

Auto fluorescent units or AFU are individual microorganisms and are reported in cells/mL. The 7000RMS illuminates the sample with a laser, resulting in Mie scattering form any particle present in the sample and also florescent scattering from metabolites (NADH and riboflavin) which are present in all bacteria. With the use of advanced algorithms and sample processing, the 7000RMS analyzes and reports the number of cells/bacteria present in the water sample as AFU.

What is the Microbial Detection Analyzer 7000RMS?

UPW and WFI. This bioburden analyzer, when used in parallel with plate counting, offers a rapid microbial method (RMM) solution for better microbial control of your water system, reducing the risk of releasing contaminated water and improving process control. The bioburden analyzer uses laser-induced fluorescence and Mie scattering to provide continuous monitoring with results every two seconds, which can give you better process transparency and thus help you to reduce cost significantly.

What are typical applications with the bioburden analyzer?

The 7000RMS online water bioburden analyzer has a variety of applications. The bioburden analyzer is used for measurements of microbial contamination in Pharmaceutical Grade Waters including Pure Water (PW), Ultrapure Water (UPW), and Water for Injection (WFI) in any industry where they are used.

What is the minimum detection size using the microbial detection analyzer?

The 7000RMS bioburden analyzer provides microbial detection of organisms down to 0.3 micron. The technology does not rely on the formation of colonies like traditional plate counting methods.

How can the analysis and response time of the bioburden analyzer improve my process efficiency?

When used in parallel with plate counting, this online water bioburden analyzer offers a rapid microbial method (RMM) solution designed to improve your process control, by providing you better understanding of your entire water loop on a regular basis giving you better process transparency and helping you to act quickly when an excursion event occurs. The analysis time is continuous, and the anlayzer provides results every two seconds, requiring no sample preparation or incubation period.

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