Innovative Techniques to Synthesize Breakthrough Molecules
Although sampling chemical reactions for offline analysis is standard, it is not always precise and reproducible. Delays in quenching can lead to variable results and inaccurate analytical information. In Pfizer's synthetic chemistry and process development laboratories, these challenges have been eliminated with an automated and robust inline method of taking representative samples from reactions, even under difficult conditions. Unattended sampling was applied in long-term stability studies over several days and to reactions which require immediate quench-in-place operation at reaction temperatures.
Reactions that Pfizer successfully sampled include:
- Thick Slurries
- Dark Mixtures With Inorganic Salts Present
- Tri-Phasic Mixtures
- Oxygen-Sensitive Reactions