The presentation - Characterize, Optimize and Scale-up Pressure Reactions - focuses on the chemistry and equipment challenges faced with pressure reactions. There are many critical design factors in characterizing and optimizing pressure reactions and these can be determined through the use of today’s available reactor and in situ analytical technologies.
Applications presented include:
- Mass transfer limitations in a hydrogenation of a substituted 2-cyclohexene-1-one
- Kinetics study of a nitrobenzene hydrogenation
The combined use of pressure reactor technology and in situ analytics (FTIR) to provide real time, valuable mechanistic information that prevents accumulation of an unstable and explosive reactive intermediate is also demonstrated.
Brian Wittkamp received his Bachelor’s degree in Analytical Chemistry from the University of Minnesota and Ph.D. in Spectroscopy from the University of North Dakota. Dr. Wittkamp's graduate studies focused on the implementation of Raman spectroscopy as an in situ monitoring tool for groundwater contaminants. Brian has worked as a technical specialist for instrumentation companies focused on NIR and FTIR for the high value chemical and petrochemical industries. Now working for METTLER TOLEDO, Brian is responsible for the worldwide market development of FTIR products in the high value chemical industries, including pressure reactions. Brian has been an invited speaker to local and international conferences, as well as published a number of papers in the environmental and continuous flow chemistry application segments.