USP Chapters 41 and 1251 on Weighing

USP Chapters 41 and 1251 on Weighing


Ensure Compliance with the Latest Recommendations

eLearning Course: Compliance with USP Chapters 41 and 1251 on Weighing








This eLearning course provides all the information required to understand the 2013 revisions to USP General Chapters 41 (Balances) and 1251 (Weighing on an Analytical Balance). A certificate will be automatically generated upon completion of the course, which should take 60-90 minutes.

The course covers:

  • The revisions to USP 41 and 1251
  • The impact this has on your weighing equipment
  • Recommended frequency of performance qualification (PQ)
  • The significance of the minimum weight of a balance – and how to calculate it
  • Repeatability and accuracy requirements
  • The importance of using a calibrated balance

Take the eLearning course on USP Chapters 41 and 1251

What is USP?

The United States Pharmacopeia (USP) is a scientific, non-governmental organization that sets the official public standards for drugs and drug products in the US. These standards include identity, strength, quality and purity of substances manufactured, distributed and consumed in the US. The USP drug standards are used in more than 140 countries and are enforceable in the US by the Food and Drug Administration (FDA). It has a similar legal status to the European Pharmacopoeia compendium in Europe.


What are USP Chapters 41 and 1251 about?

  • USP General Chapter 41 "Balances” is mandatory and states the requirements for balances used for materials that must be accurately weighed. Weighing should be performed using a balance that is calibrated over the operating range and meets the requirements defined for repeatability and accuracy.
  • USP General Chapter 1251 "Weighing on an Analytical Balance" is a guideline applicable to balances used in all analytical procedures. It provides information on installation and operational qualification (IQ/OQ), performance qualification and balance checks (routine testing), minimum weight and balance operation. See the webinar on Calibration and Qualification of Laboratory Instruments.
How can METTLER TOLEDO support you?

Related Documents

Webinars and eLearnings


Why Do I Need a Balance or Scale Calibration With a Certificate?



Routine Testing of Balances and Scales



Compliant with European Pharmacopoeia Chapter 2.1.7. on Balances