Biocatalysis | Enzymatic Catalysis

Biocatalysis | Enzymatic Catalysis

Monitor and Understand the Progression and Mechanism of Biotransformations in Real Time

Biocatalysis, also referred to as enzymatic catalysis or biotransformation, is the use of enzymes to catalyze chemical reactions. The field for biocatalysis continues to grow as chemists strive towards more efficient and green chemistry processes, while reducing costs.

The use of enzymes, isolated enzymes or whole cells, as catalysts offer several advantages over traditional metal catalysts. Firstly, enzymes are highly efficient, providing faster reaction rates than chemically catalyzed reactions, and at lower concentrations. Secondly, enzymes function under mild temperature and pH conditions, as well as in aqueous environments, enabling a tendency towards green large-scale processes. Thirdly, enzymes offer high specificity, being chemo-, regio-, diastereo- and enantiospecific, targeting specific functional groups. Finally, enzymes lower the cost of chemical synthesis, and can be mass produced.

The pharmaceutical, chemical, petroleum, agricultural, polymer and electronics industries have reported applications of enzyme catalyzed syntheses.  Industrial scale organic biotransformations include hydrolysis, oxidation, reduction, addition – elimination, halogenation and dehalogenation, and transesterification reactions.

Similarly to metal catalyzed reactions, in situ FTIR spectroscopy monitors the progress of biocatalytic conversions to determine reaction endpoints, understand reaction mechanisms, monitor the formation of intermediates, and perform reaction kinetics analysis, all in order to optimize reaction conditions and increase product yield and purity.  Integrated with ReactIR™, chemical synthesis reactors support enzyme screeningroute scoutingprocess development and optimization, and process scale-up studies to ultimately improve product yield and quality. Flow chemistry enhances biocatalysis processes.

Biocatalysis | Enzymatic Catalysis
Biocatalysis | Enzymatic Catalysis

Applications

Chemical Synthesis
Screen and Optimize Catalysis, Hydrogenation, Polymer Synthesis and Other Reactive Chemical Syntheses

Chemists working in chemical synthesis discover and develop innovative chemical reactions and processes.

Chemical Synthesis

Chemists working in chemical synthesis discover and develop innovative chemical reactions and processes.

Publications

Webinars

Solid-Liquid Separations in Bioprocesses
This webinar reviews the application of in situ PAT to understand the flocculation mechanism in bioprocesses, and how the real-time measurement of par...
Professor Robson Storey - University of Southern Mississippi
Real-time in situ mid-infrared monitoring of polymerization reactions involving isobutylene and styrene is the focus of this presentation. Professor R...
Enzyme-Catalyzed Reactions Monitoring
Biocatalysis, also known as enzymatic catalysis, is the use of enzymes to catalyze chemical reactions. Enzymes offer several advantages over tradition...
Enzymatic Esterification Conversion Prediction
This online seminar focuses on the implementation of FTIR-based online analytics in the production of fatty acid esters. A new process using Novozym 4...

White Papers

Next Steps in Enzymatic Catalysis
Biocatalysis, also known as enzymatic catalysis, is the use of enzymes to catalyze chemical reactions. Enzymes offer several advantages over tradition...
Understand and Control Bioprocesses
Inline process analytical technology increases yield and product quality and improves the understanding of bioprocesses. Our white paper discusses the...

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