Tablet and Capsule Disintegration and Dissolution - METTLER TOLEDO

Tablet and Capsule Disintegration and Dissolution

Study Particle Size and Count During Dissolution Testing and Formulation Development

Quantifying tablet disintegration profiles in situ and in real time enables scientists to reliably understand the breakage and dispersion mechanisms that govern Active Pharmaceutical Ingredient (API) release rates. This essential process knowledge can support the prediction of in vivo drug release profiles during formulation development and can help identify the root cause of inconsistencies during release testing.

ParticleTrack with FBRM is a probe-based technology that allows changes in particle size and count to be monitored continuously as tablets or capsules disintegrate and dissolve.

The resulting mechanistic information complements traditional offline dissolution testing methods and can support the development and release of bioavailable, stable and manufacturable dosage forms.

Tablet and Capsule Disintegration and Dissolution
Tablet and Capsule Disintegration and Dissolution

Recently, METTLER TOLEDO collaborated with Actera Pharmaceuticals, pioneers in the use of ParticleTrack with FBRM technology, to fully develop the innovative in situ particle characterization applications for solid oral dosage formulation development.

"We find FBRM can elucidate the kinetics and mechanisms of tablet, granule, and particle disagglomeration in dosage forms, and is a more sensitive physical characterization method than compendial USP dissolution"  Mark Menning, Actera Pharmaceuticals

"The FBRM technology, where applied appropriately, can facilitate improved optimization of drug product formulation and process parameters, bridging of in vitro to human bioavailability performance, and elucidate complex physical stability changes" Sean Dalziel, Actera Pharmaceuticals.

To learn more about how Actera Pharmaceuticals or ParticleTrack with FBRM technology can improve your formulation development program, click the Request Info button below.

Reference
Fumaric Acid Microenvironment Tablet Formulation and Process Development for Crystalline Cenicriviroc Mesylate, a BCS IV Compound
By: Menning, Mark M., and Sean M. Dalziel.
Molecular pharmaceutics
2013-12-04

Applications

Publications

Related Products

 
 
 
 
 
 
 
Thank you for visiting www.mt.com. We have tried to optimize your experience while on the site, but we noticed that you are using an older version of a web browser. We would like to let you know that some features on the site may not be available or may not work as nicely as they would on a newer browser version. If you would like to take full advantage of the site, please update your web browser to help improve your experience while browsing www.mt.com.