Dry Granulation Using Roller Compaction - METTLER TOLEDO

Dry Granulation Using Roller Compaction

Optimize granulation development and scale-up by directly monitoring granule distribution in real time

Particles play a critical role in granulation product quality.  The particle distribution from dry granulation or roller compaction equipment is a key process parameter in ensuring consistency of granule flowability, tabletability, and product bioavailability.

Formulators and engineers can optimize granulation development and scale-up by directly monitoring the granule distribution in real time.  For dry granulation, in process FBRM® and PVM® provide immediate feedback for batch control of critical process variables such as compaction force and rotor speed, without the need for offline sampling analysis.

Process Analytical Technology (PAT) tools in granulation promote faster and more thorough mapping of the experimental design space, enable consistent scale-up and tech transfer, and allow control of the process to a desired endpoint that assures downstream critical product quality and process efficiency.

Dry Granulation Using Roller Compaction
Dry Granulation Using Roller Compaction

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