Chemical Synthesis | Lab Instruments, Automation

Chemical Synthesis

Producing Quality, Economically-Viable Molecules

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Spectrometers for Chemical Synthesis

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Synthetic Organic Chemistry Applications

Control Residual Isocyanate
Process Analytical Technology for Continuous Measurement of NCO

Isocyanates are critical building blocks for high performance polyurethane-based polymers that make up coatings, foams, adhesives, elastomers, and insulation. Concerns over exposure to residual isocyanates led to new limits for residual isocyanates in new products. Traditional analytical methods for measuring the residual isocyanate (NCO) concentration using offline sampling and analysis raise concerns. In situ monitoring with process analytical technology addresses these challenges and enables manufacturers and formulators to ensure that product quality specifications, personnel safety, and environmental regulations are met.

Measuring Polymerization Reactions
Methods and Techniques to Develop Synthetic Polymer Chemistry

Polymerization reaction measurement is crucial to produce material that meets requirements, including Immediate understanding, accurate and reproducible, Improved safety.

Impurity Profiling of Chemical Reactions
Automated Process Development Strategies for Chemists

Impurity profiling aims at identification and subsequent quantification of specific components present at low levels, usually less than 1% and ideally lower than 0.1 %.

Grignard

Grignard Ayıraçlarının Monitör ve Kontrol Sentezi

Hidrojenasyon Reaksiyonları
Yüksek Sıcaklıkta ve Basınçta Güvenli Reaksiyon izleme

Hidrojenasyon reaksiyonları, birden fazla bağı tek bağa indirgemek için dökme ve ince kimyasal maddelerin üretiminde geniş çapta kullanılır. Katalizörler genellikle bu reaksiyonları ve reaksiyon sıcaklıklarını, basıncı, alt katman yüklemeyi, katalizör yüklemeyi ve ajitasyon oranını (tümü hidrojen gazı alımını ve genel reaksiyon performansını etkiler) desteklemek için kullanılır. Bu enerjik reaksiyonu anlamak çok önemlidir ve HPLC analizini desteklemek için in-situ FTIR gibi PAT teknolojisi, kalorimetri ve otomatik in-situ numune alma işlemleri güvenli, optimize edilmiş ve iyi tanımlanmış bir kimya sağlar.

High Pressure Reactions
Understand and Characterize High Pressure Reactions Under Challenging Sampling Conditions

Many processes require reactions to be run under high pressure. Working under pressure is challenging and collecting samples for offline analysis is difficult and time consuming. A change in pressure could affect reaction rate, conversion and mechanism as well as other process parameters plus sensitivity to oxygen, water, and associated safety issues are common problems.

Halogenation Reactions
Key Syntheses in Pharmaceutical and Polymer Chemistry

Halogenation occurs when one of more fluorine, chlorine, bromine, or iodine atoms replace one or more hydrogen atoms in an organic compound. Depending on the specific halogen, the nature of the substrate molecule and overall reaction conditions, halogenation reactions can be very energetic and follow different pathways. For this reason, understanding these reactions from a kinetics and thermodynamic perspective is critical to ensuring yield, quality and safety of the process.

Catalytic Reactions
Accelerate Chemical Reactions With a Catalyst

Catalysts create an alternative path to increase the speed and outcome of a reaction, so a thorough understanding of the reaction kinetics is important. Not only does that provide information about the rate of the reaction, but also provides insight into the mechanism of the reaction. There are two types of catalytic reactions: heterogeneous and homogeneous. Heterogeneous is when the catalyst and reactant exist in two different phases. Homogeneous is when the catalyst and the reactant are in the same phase..

sentez reaksiyonları
Hayat Değiştiren Ürünleri Sunmak İçin Otomatik Araçlar Sağlama

Sentez reaksiyonu basit elementlerin veya bileşiklerin bir araya gelerek daha karmaşık bir ürün oluşturduğu kimyasal bir prosestir. A + B → AB denklemi ile temsil edilir.

Deney Tasarımı (DoE)
Reaksiyon Optimizasyonuna İstatistiksel Bir Yaklaşım

Deney Tasarımı (DoE), kimyasal proses optimizasyonu için deneylerin iyi kontrol edilen ve tekrarlanabilir koşullar altında gerçekleştirilmesini gerektirir. Kimyasal sentez reaktörleri, yüksek kaliteli veriler sağlayan DoE çalışmaları yapmak üzere tasarlanmıştır.

Reaction Mechanism Pathway
Fundamental Understanding of Chemical Reactions and Factors Affecting Them

Reaction mechanisms describe the successive steps at the molecular level that take place in a chemical reaction. Reaction mechanisms cannot be proven, but rather postulated based on empirical experimentation and deduction. In situ FTIR spectroscopy provides information to support reaction mechanisms hypotheses.

Organometallic Synthesis
Understanding and Control of Organometallic Compounds

Organometallic Synthesis, or Organometallic Chemistry, refers to the process of creating organometallic compounds, and is among the most researched areas in chemistry. Organometallic compounds are frequently used in fine chemical syntheses and to catalyze reactions. In situ Infrared and Raman spectroscopy are among the most powerful analytical methods for the study of organometallic compounds and syntheses.

Oligonucleotide Synthesis
Ensure Yield, Purity, and Cost Objectives

Oligonucleotide synthesis is the chemical process by which nucleotides are specifically linked to form a product of desired sequenced.

What is Alkylation?
For Key Reactions in Organic Chemistry

Alkylation is the process by when an alkyl group is added to a substrate molecule. Alkylation reactions are a widely used technique in organic chemistry.

Epoxides
Key Functional Groups for Synthesis of Polymers and Pharmaceuticals

This page outlines what epoxides are, how they are synthesized and technology to track reaction progression, including kinetics and key mechanisms.

Key C-C Bond-Forming Reactions in Molecular Synthesis

The Suzuki and related cross-coupling reactions use transition metal catalysts, such as palladium complexes, to form C-C bonds between alkyl and aryl halides with various organic compounds.

Lithiation Organolithium Reactions
Key Reagents for Synthesizing Complex Molecules

Lithiation and organolithium reactions are key in the development of complex pharmaceutical compounds; organolithium compounds also act as initiators in certain polymerization reactions.

Functionalization of Carbon Bonds

C-H bond activation is a series of mechanistic processes by which stable carbon-hydrogen bonds in organic compounds are cleaved.

Organocatalysis
For Metal-Free Asymmetric Synthesis of Chiral Molecules

Organocatalysis refers to the employment of particular organic molecules to speed up chemical reactions through catalytic activation.

hydroformylation reaction example
Understanding Key Mechanisms and Improve Catalytic Processes

Hydroformylation, also known as oxo synthesis, is a chemical reaction involving the addition of carbon monoxide (CO) and hydrogen (H₂) to an unsaturated compound, typically an alkene or alkyne. The reaction is catalyzed by transition metal complexes, such as rhodium or cobalt, leading to the formation of aldehydes or aldehyde derivatives.

click chemistry tools for click reactions
In-Situ Chemistry to Support Click Reactions

Click reactions refer to chemical reactions that meet the criteria of click chemistry. Click reactions are typically fast, high-yielding, and occur under mild conditions, making them ideal for a variety of applications.

Sürekli Karıştırmalı Depo Reaktörleri CSTR
Kimyasal ve Biyolojik Sentezler İçin Akış Teknolojisi

Sürekli karıştırılan depo reaktör (CSTR) reaksiyon ürünü kabın üzerinden çıkarken reaktiflerin ve reaktanların bir reaktör aktığı bir kaptır.

Control Residual Isocyanate

Isocyanates are critical building blocks for high performance polyurethane-based polymers that make up coatings, foams, adhesives, elastomers, and insulation. Concerns over exposure to residual isocyanates led to new limits for residual isocyanates in new products. Traditional analytical methods for measuring the residual isocyanate (NCO) concentration using offline sampling and analysis raise concerns. In situ monitoring with process analytical technology addresses these challenges and enables manufacturers and formulators to ensure that product quality specifications, personnel safety, and environmental regulations are met.

Measuring Polymerization Reactions

Polymerization reaction measurement is crucial to produce material that meets requirements, including Immediate understanding, accurate and reproducible, Improved safety.

Impurity Profiling of Chemical Reactions

Impurity profiling aims at identification and subsequent quantification of specific components present at low levels, usually less than 1% and ideally lower than 0.1 %.

Grignard

Grignard Ayıraçlarının Monitör ve Kontrol Sentezi

Hidrojenasyon Reaksiyonları

Hidrojenasyon reaksiyonları, birden fazla bağı tek bağa indirgemek için dökme ve ince kimyasal maddelerin üretiminde geniş çapta kullanılır. Katalizörler genellikle bu reaksiyonları ve reaksiyon sıcaklıklarını, basıncı, alt katman yüklemeyi, katalizör yüklemeyi ve ajitasyon oranını (tümü hidrojen gazı alımını ve genel reaksiyon performansını etkiler) desteklemek için kullanılır. Bu enerjik reaksiyonu anlamak çok önemlidir ve HPLC analizini desteklemek için in-situ FTIR gibi PAT teknolojisi, kalorimetri ve otomatik in-situ numune alma işlemleri güvenli, optimize edilmiş ve iyi tanımlanmış bir kimya sağlar.

High Pressure Reactions

Many processes require reactions to be run under high pressure. Working under pressure is challenging and collecting samples for offline analysis is difficult and time consuming. A change in pressure could affect reaction rate, conversion and mechanism as well as other process parameters plus sensitivity to oxygen, water, and associated safety issues are common problems.

Halogenation Reactions

Halogenation occurs when one of more fluorine, chlorine, bromine, or iodine atoms replace one or more hydrogen atoms in an organic compound. Depending on the specific halogen, the nature of the substrate molecule and overall reaction conditions, halogenation reactions can be very energetic and follow different pathways. For this reason, understanding these reactions from a kinetics and thermodynamic perspective is critical to ensuring yield, quality and safety of the process.

Catalytic Reactions

Catalysts create an alternative path to increase the speed and outcome of a reaction, so a thorough understanding of the reaction kinetics is important. Not only does that provide information about the rate of the reaction, but also provides insight into the mechanism of the reaction. There are two types of catalytic reactions: heterogeneous and homogeneous. Heterogeneous is when the catalyst and reactant exist in two different phases. Homogeneous is when the catalyst and the reactant are in the same phase..

sentez reaksiyonları

Sentez reaksiyonu basit elementlerin veya bileşiklerin bir araya gelerek daha karmaşık bir ürün oluşturduğu kimyasal bir prosestir. A + B → AB denklemi ile temsil edilir.

Deney Tasarımı (DoE)

Deney Tasarımı (DoE), kimyasal proses optimizasyonu için deneylerin iyi kontrol edilen ve tekrarlanabilir koşullar altında gerçekleştirilmesini gerektirir. Kimyasal sentez reaktörleri, yüksek kaliteli veriler sağlayan DoE çalışmaları yapmak üzere tasarlanmıştır.

Reaction Mechanism Pathway

Reaction mechanisms describe the successive steps at the molecular level that take place in a chemical reaction. Reaction mechanisms cannot be proven, but rather postulated based on empirical experimentation and deduction. In situ FTIR spectroscopy provides information to support reaction mechanisms hypotheses.

Organometallic Synthesis

Organometallic Synthesis, or Organometallic Chemistry, refers to the process of creating organometallic compounds, and is among the most researched areas in chemistry. Organometallic compounds are frequently used in fine chemical syntheses and to catalyze reactions. In situ Infrared and Raman spectroscopy are among the most powerful analytical methods for the study of organometallic compounds and syntheses.

Oligonucleotide Synthesis

Oligonucleotide synthesis is the chemical process by which nucleotides are specifically linked to form a product of desired sequenced.

What is Alkylation?

Alkylation is the process by when an alkyl group is added to a substrate molecule. Alkylation reactions are a widely used technique in organic chemistry.

Epoxides

This page outlines what epoxides are, how they are synthesized and technology to track reaction progression, including kinetics and key mechanisms.

The Suzuki and related cross-coupling reactions use transition metal catalysts, such as palladium complexes, to form C-C bonds between alkyl and aryl halides with various organic compounds.

Lithiation Organolithium Reactions

Lithiation and organolithium reactions are key in the development of complex pharmaceutical compounds; organolithium compounds also act as initiators in certain polymerization reactions.

C-H bond activation is a series of mechanistic processes by which stable carbon-hydrogen bonds in organic compounds are cleaved.

Organocatalysis

Organocatalysis refers to the employment of particular organic molecules to speed up chemical reactions through catalytic activation.

hydroformylation reaction example

Hydroformylation, also known as oxo synthesis, is a chemical reaction involving the addition of carbon monoxide (CO) and hydrogen (H₂) to an unsaturated compound, typically an alkene or alkyne. The reaction is catalyzed by transition metal complexes, such as rhodium or cobalt, leading to the formation of aldehydes or aldehyde derivatives.

click chemistry tools for click reactions

Click reactions refer to chemical reactions that meet the criteria of click chemistry. Click reactions are typically fast, high-yielding, and occur under mild conditions, making them ideal for a variety of applications.

Sürekli Karıştırmalı Depo Reaktörleri CSTR

Sürekli karıştırılan depo reaktör (CSTR) reaksiyon ürünü kabın üzerinden çıkarken reaktiflerin ve reaktanların bir reaktör aktığı bir kaptır.

Yayınlar

Publications on Synthetic Organic Chemistry

White Papers

Çığır Açan Molekülleri Sentezleme Teknikleri
Organik kimyadaki gelişmeler, araştırmacıların moleküllerle ilgili araştırma ve geliştirme çalışmalarını genişletmelerine ve proses şartlarını optimiz...
Modern Sentez Laboratuvarı
Bu teknik dokümanda; özellikle kimyacılar için tasarlanmış, deneysel opsiyonları genişleten, zahmetli işleri otomatik hâle getiren ve tek dokunuşta yü...
Yerinde Spektroskopi Kullanılarak Kolaylaştırılmış Metal Dönüşümleri
Özellikle reaksiyon analizi alanında pek çok deneyin kalitesi büyük ölçüde reaksiyonların tam başlangıç ve bitiş noktalarının belirlenmesine bağlıdır....
In Situ Monitoring of Chemical Reactions
Araştırmacılar hızlı ve düşük maliyetli kimyasal ürünler sunmaları gerektiğinde 'Daha az şeyle nasıl daha fazlasını yapabilirim?', kimyasal geliştirme...
Sodyum Borhidrür Azaltımının Güvenli Bir Şekilde Çalışması için Proses FTIR
Roche'un İrlanda tesisinden John O'Reilly, sodyum borhidrür azaltımının güvenli bir şekilde çalışması için Proses FTIR kullanan sürdürülebilir Proses...
Gerçek Zamanlı Reaksiyon İzleme hakkında teknik doküman: İkili Hidroformilleme/Hidrojenlenme
Gerçek zamanlı olarak ve in-situ yapılan orta-FTIR reaksiyon izlemesi, katalizör etkinliğinin ve kuvvetinin daha iyi şekilde anlaşılmasına olanak sağl...
Grignard Kimyasını Geliştirme Ölçekleme Sürecini Kontrol Etmek İçin 4 Adım
Ekzotermik kimyasal reaksiyonlarda, özellikle de ölçek büyütme sırasında çeşitli riskler vardır. Önemli kimya ve ilaç şirketleri tarafından yayınlanan...
Sürekli Reaksiyon Optimizasyonu Deneylerinin Hızlı Analizi
Sürekli Reaksiyon Optimizasyonu Deneylerinin Hızlı Analizi adlı teknik dokümanda kimyasal reaksiyonların nasıl optimize edileceği anlatılmaktadır.
3 Reaction Monitoring Case Studies
In this whitepaper, three case studies carried out at GlaxoSmithKline (GSK) demonstrate how probe-based and real-time FTIR instrumentation helped to c...
Modern Sentez Laboratuvarı
Bu teknik dokümanda; özellikle kimyacılar için tasarlanmış, deneysel opsiyonları genişleten, zahmetli işleri otomatik hâle getiren ve tek dokunuşta yü...
Kimyasal Reaksiyon Profili Oluşturma: Bir İnceleme
"In-Situ Reaksiyon Profili Oluşturma: Bir Literatür İncelemesi" adlı bu teknik dokümanda, reaksiyonun kapsamlı şekilde anlaşılması için in-situ FTIR S...
Reaction Insight from Every Experiment
This paper presents five examples taken from recent journal articles in which HPLC alone was not sufficient to provide the insight scientists needed....

Webinars

Hydrogenation Under High Pressure
This presentation discusses the implementation of Fourier Transform Infrared (FTIR) reaction monitoring technology to provide knowledge and understand...
Impact of Process Intensification on Process Safety
This presentation discusses how Nalas Engineering safely handles high energy materials and hazardous chemistry.
Reaction Kinetics Progress Analysis Ryan Baxter
This webinar explores a graphical analysis approach to rationalize unusual kinetics in C-H activations. The Reaction Progress Kinetic Analysis (RPKA)...
Hydrogenation Under High Pressure
This presentation discusses the implementation of Fourier Transform Infrared (FTIR) reaction monitoring technology to provide knowledge and understand...
DoE to Peptide Synthesis
Learn how Design of Experiments (DoE) is applied to chemical synthesis at Lonza Peptide.
New Radical Reactions Enabled by In Situ Reaction Monitoring
Presented by Professor Ryan Baxter of the University of California-Merced, this on-demand webinar discusses research that involved new radical reactio...
Process Development and Kinetic Understanding
Presented by Eric Moschetta, this on-demand webinar describes how AbbVie built a robust kinetic model to understand a late stage API process
Alkylation Reaction Development
Kevin Stone discusses how Merck Chemical Engineering Research & Development (CERD) leverages process fingerprinting tools in the development of an Alk...

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Synthetic Organic Chemistry Tools