Process Analytical Technology PAT | R&D, Scale-up & Manufacturing

Process Analytical Technology (PAT)

PAT is Changing Chemical Process Development, Scale-up, and Manufacturing

Process Analytical Technology (PAT)

Process Analytical Technology in R&D
Process Analytical Technology (PAT)
In Situ Reaction Analysis Tools
Inline Particle Characterization
Heat Flow Calorimetry in PAT

Aplikácie

Measure Crystal Size Distribution
Improve Crystallization with Inline Particle Size, Shape, and Count Measurement

In-process probe-based technologies are applied to track particle size and shape changes at full concentration with no dilution or extraction necessary. By tracking the rate and degree of change to particles and crystals in real time, the correct process parameters for crystallization performance can be optimized.

Crystallization and Precipitation
Optimize Crystal Size, Yield and Purity

Optimization and scale-up of crystallization and precipitation to produce a product that consistently meets purity, yield, form and particle size specifications can be one of the biggest challenges of process development.

Chemical Process Development & Scale-Up
Design Robust and Sustainable Chemical Processes For Faster Transfer To Pilot Plant and Production

Design Robust and Sustainable Chemical Processes For Faster Transfer To Pilot Plant and Production

Impurity Profiling of Chemical Reactions
Continuous Automated Reaction Sampling Improves Productivity and Understanding for Chemists

Knowledge of impurity kinetics and mechanism of formation is important in determining reaction end-point in chemical and process development studies. Accurate, reproducible, and representative reactions samples are necessary for these studies.

Chemical Reaction Kinetics Studies
Study Chemical Reaction Rates and Measure Kinetics Inline

In situ chemical reaction kinetics studies provide an improved understanding of reaction mechanism and pathway by providing concentration dependences of reacting components in real-time. Continuous data over the course of a reaction allows for the calculation of rate laws with fewer experiments due to the comprehensive nature of the data.  Reaction Progression Kinetics Analysis (RPKA) uses in situ data under synthetically relevant concentrations and captures information throughout the whole experiment ensuring that the complete reaction behavior can be accurately described.

Flow Chemistry
Improve Safety, Reduce Cycle Time, Increase Quality and Yield

Continuous flow chemistry opens options with exothermic synthetic steps that are not possible in batch reactors, and new developments in flow reactor design provide alternatives for reactions that are mixing limited in batch reactors. This can often result in better product quality and higher yield.  When coupled with Process Analytical Technology (PAT), flow chemistry allows for rapid analysis, optimization, and scale-up of a chemical reaction.

Grignard Reaction Mechanisms
Understand and Control Exothermic Events

Grignard reactions are one of the most important reaction classes in organic chemistry. Grignard reactions are useful for forming carbon-carbon bonds. Grignard reactions form alcohols from ketones and aldehydes, as well as react with other chemicals to form a myriad of useful compounds. Grignard reactions are performed using a Grignard reagent, which is typically a alkyl-, aryl- or vinyl- organomagnesium halide compound. To ensure optimization and safety of Grignard reactions in research, development and production, in situ monitoring and understanding reaction heat flow is important.

Formulations and Product Development
Develop Solid and Liquid Formulations With Desired Disintegration and Dissolution Profiles

Develop Solid and Liquid Formulations With Desired Disintegration and Dissolution Profiles

Measure Crystal Size Distribution

In-process probe-based technologies are applied to track particle size and shape changes at full concentration with no dilution or extraction necessary. By tracking the rate and degree of change to particles and crystals in real time, the correct process parameters for crystallization performance can be optimized.

Crystallization and Precipitation

Optimization and scale-up of crystallization and precipitation to produce a product that consistently meets purity, yield, form and particle size specifications can be one of the biggest challenges of process development.

Chemical Process Development & Scale-Up

Design Robust and Sustainable Chemical Processes For Faster Transfer To Pilot Plant and Production

Impurity Profiling of Chemical Reactions

Knowledge of impurity kinetics and mechanism of formation is important in determining reaction end-point in chemical and process development studies. Accurate, reproducible, and representative reactions samples are necessary for these studies.

Chemical Reaction Kinetics Studies

In situ chemical reaction kinetics studies provide an improved understanding of reaction mechanism and pathway by providing concentration dependences of reacting components in real-time. Continuous data over the course of a reaction allows for the calculation of rate laws with fewer experiments due to the comprehensive nature of the data.  Reaction Progression Kinetics Analysis (RPKA) uses in situ data under synthetically relevant concentrations and captures information throughout the whole experiment ensuring that the complete reaction behavior can be accurately described.

Flow Chemistry

Continuous flow chemistry opens options with exothermic synthetic steps that are not possible in batch reactors, and new developments in flow reactor design provide alternatives for reactions that are mixing limited in batch reactors. This can often result in better product quality and higher yield.  When coupled with Process Analytical Technology (PAT), flow chemistry allows for rapid analysis, optimization, and scale-up of a chemical reaction.

Grignard Reaction Mechanisms

Grignard reactions are one of the most important reaction classes in organic chemistry. Grignard reactions are useful for forming carbon-carbon bonds. Grignard reactions form alcohols from ketones and aldehydes, as well as react with other chemicals to form a myriad of useful compounds. Grignard reactions are performed using a Grignard reagent, which is typically a alkyl-, aryl- or vinyl- organomagnesium halide compound. To ensure optimization and safety of Grignard reactions in research, development and production, in situ monitoring and understanding reaction heat flow is important.

Formulations and Product Development

Develop Solid and Liquid Formulations With Desired Disintegration and Dissolution Profiles

Publikácie na stiahnutie

White Papers

Vývoj procesu efektívnej kryštalizácie
Kvalita procesu kryštalizácie významným spôsobom ovplyvňuje kvalitu finálneho produktu. Naša nová biela kniha obsahuje základné informácie o kryštaliz...
How to Optimize a Crystallization Step Using Simple Image Analysis
By quickly identifying unnecessary hold times and determining how cooling rate influences crystal growth and nucleation, the cycle time for an interme...
Procesná funkcia FTIR na bezpečnú redukciu borohydridu sodného
John O'Reilly zo spoločnosti Roche Ireland predstavuje udržateľný systém procesnej analytickej technológie (PAT) s využitím procesnej funkcie FTIR na...
In situ monitorovanie chemických reakcií
Stálou témou v laboratóriách chemického vývoja je otázka „Ako vykonať viac použitím menšieho objemu prostriedkov?“, keďže jednou z úloh výskumných pra...
Rýchla analýza experimentov s optimalizáciou kontinuálnych reakcií
Biela kniha s názvom Rýchla analýza experimentov s optimalizáciou kontinuálnych reakcií uvádza spôsoby optimalizácie chemických reakcií.
Štúdie efektívneho experimentálneho dizajnu
Táto dokumentácia obsahuje informácie o prístupe experimentálneho dizajnu (DoE) a o tom, ako sa používa na identifikáciu vzťahov medzi parametrami, de...
Riziká vyplývajúce z nárastu teploty
V rámci rozširovania chemických procesov do výroby je mimoriadne dôležitým aspektom bezpečnosti procesov porozumenie zmenám teploty a súvisiaceho tepl...
PAT for Emulsions
Use PAT for emulsions and suspension characterization without the need for sampling or sample prep.
Monitor Tablet & Granule Disintegration
The role of in-process particle measurement to complement traditional API dissolution studies is presented. The use of particle size and count measure...
Particle Size Analysis for Process Optimization
This white paper introduces some of the most common particle size analysis approaches and how they can be deployed for the effective delivery of high...

On-Demand Webinars

Breaking Barriers to Manufacturing Innovation
Frederic Buono discusses how Boehringer Ingelheim uses continuous flow technology to break barriers in manufacturing innovation.
Crystallization Image Analysis
Presented by Prof. Zoltan Nagy of Purdue University, this talk provides an overview of recent advances of applications for in situ imaging and image a...
Flow and Batch Chemistry Monitoring
Charles Goss presents examples illustrating how GlaxoSmithKline (GSK) monitors flow and batch chemistry unit operations in both laboratory and pilot p...
Liquid-Liquid Phase Separation
This presentation describes a strategy employed to design and develop robust, scalable crystallization processes that avoids Liquid-Liquid Phase Separ...
New Tools For Continuous Flow Chemistry
Andrea Adamo of MIT and Zaiput Flow Technologies discusses new tools for continuous flow chemistry advancement.
Agglomeration & Crystallization Using Particle Measurement
This presentation details how using data from in situ particle vision and measurement tools can be used to determine particle size and shape trends re...
Vývoj a rozširovanie procesov v spoločnosti Lubrizol
Tento webový seminár sa zameriava na spôsob zlepšenia vývoja procesov a ich rozširovania do výroby využitím kalorimetrie a analýzy procesov in situ. N...
Vývoj chemických procesov v spoločnosti Merck
Shane Grosser vysvetľuje, ako laboratórium na intenzifikáciu vývoja procesov spoločnosti Merck vyvíja nové nástroje a metódy na zvýšenie rýchlosti a o...

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