Safe, Unattended Dosing in Chemical Development & Scale-up - METTLER TOLEDO
Case Study

Safe, Unattended Dosing in Chemical Development & Scale-up

Case Study

Automate Dosing and Run Highly Exothermic Reactions Unattended

Dosing in Chemical Development and Scale-up
Dosing in Chemical Development and Scale-up

As exothermic reactions pose inherent safety hazards in chemical development and scale-up, either constant supervision or automated and safe dosing control has traditionally been required.

This case study describes how the Process R&D Group at a leading pharmaceutical company, Grünenthal GmbH, Germany, now runs scale-up experiments safely without manual supervision, in order to increase productivity without increasing staff.  Grünenthal Process R&D now automates semi-batch dosing in their multi-liter jacketed lab reactors, and runs highly exothermic reactions unattended without compromising safety.

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