This webinar focuses on how to improve process development and scale-up by leveraging calorimetry and in situ process analysis. In order to provide the best possible customer service, Lubrizol redefined traditional process development to reduce the time and complexity of new product development, and scale-up/scale-down optimization.
Dosing in Chemical Development and Scale-up
As exothermic reactions pose inherent safety hazards in chemical development and scale-up, either constant supervision or automated and safe dosing control has traditionally been required.
This case study describes how the Process R&D Group at a leading pharmaceutical company, Grünenthal GmbH, Germany, now runs scale-up experiments safely without manual supervision, in order to increase productivity without increasing staff. Grünenthal Process R&D now automates semi-batch dosing in their multi-liter jacketed lab reactors, and runs highly exothermic reactions unattended without compromising safety.