Modeling & Feedback Control of Batch & Continuous Crystallization Systems

During this presentation, Professor Zoltan Nagy of Purdue University gives an overview of recent advances in quantitative monitoring and feedback control of batch and continuous crystallization processes.

The concept of composite sensor array is illustrated by integrating two PAT tools with other in situ and inline analytical technologies. Sensor models of the probes will be presented that allow the use of the information provided by this systems in the implementation of a novel model predictive control approaches. The sensor model coupled with 2D population balance model of the crystallization system allows the model-based design and control of crystal size and shape in crystallization processes.

Integration of these tools with inline UPLC is also illustrated a comprehensive crystallization monitoring platform, integrated in the Crystallization Process Informatics System. The application of automated direct nucleation control (DNC) to integrated continuous crystallization and wet milling processes will be discussed. A novel process intensification approach via continuous spherical plug-flow crystallization with feedback control will also be presented. These case studies and novel applications and approaches represent the foundation of the new quality-by-control (QbC) paradigm, in which reliable, robust PAT tools represent a critical role.

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Who Should View This?
Chemists and Chemical Engineers working in the Pharmaceutical and Chemical Industries as well as in Academic Research.

About the Presenter

Dr. Zoltan Nagy

Professor of Chemical Engineering, Purdue University

Dr. Zoltan Nagy is a Professor of Chemical Engineering at Purdue University. He joined Purdue in fall 2012 from Loughborough University, UK, where he was a professor of process systems engineering and Director of the Departmental Pharmaceutical Engineering Research Centre. Dr. Nagy has over 20 years of experience in advanced process control, process analytical technologies, crystallization modeling and control approaches and advanced control of particulate systems. His current research focuses on the application of systems approaches and tools in the design and robust control of batch and continuous crystallization systems, process analytical technologies and integrated particulate manufacturing processes. He has authored more than 180 journal papers and is the co-author of 2 books. He has given over 250 invited seminars at conferences, universities and companies worldwide. Dr. Nagy is the Founding Editor of the Pharmaceutical Engineering Subject area of Chemical Engineering Research and Design, and associate editor of four other international journals in the area of process control. Dr. Nagy is member of the American Association for Crystallization Technologies, and the Crystallization Working Party of the European Federation of Chemical Engineers. He received awards and best paper prizes in the areas of crystallization and control.