Grace Russell obtained her PhD from Massachussetts Institute of Technology (MIT) working with Tim Jamison in 2019. During her time in Professor Jamison's lab, Russell worked on developing new technologies for continuous flow synthesis including end-to-end API syntheses of linezolid, nicardipine and rufinamide. Additionally, Russell contributed to the development of a plug-and-play automated flow system for automated optimization of organic reactions. Since 2019, Russell has been at Snapdragon chemistry where she focuses on continuous flow process development using enabling technologies.
Accelerate Process Development with Flow Technologies
Continuous Flow Technologies Enable Creative Solutions for Hard Process Development Challenges
In this presentation, Grace Russell PhD of Snapdragon Chemistry presents a scalable, purified diazomethane production and consumption that is suitable for sensitive organic reactions. Snapdragon utilizes a commercially available membrane separator to extract diazomethane using nitrogen gas and produce it on a synthetically useful scale of 0.44 mol/hour. This powerful reagent is then consumed in a sensitive palladium catalyzed cyclopropanation reaction.
The presenter also discusses a system for automated optimization. This tool couples custom-made components and state-of-the-art technologies to create a reliable and universal sampling platform.
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