Karl Fischer Titration Guide, Part 2 — Sample Preparation explains more advanced sample preparation procedures than the simple sample dissolution in the titration cell.
Karl Fischer Titration Guide Part 2 uses METTLER TOLEDO’s expert knowledge of Karl Fischer titration to explain more advanced sample preparation procedures than the simple sample dissolution in the titration cell
The Karl Fischer method determines water content specifically and is easily applied to a huge variety of samples. It is a common standard method in R&D, quality control and production monitoring.
However, the method requires adequate sample preparation in order to release entrapped, capillary-bound or water of crystallization. The water molecules need to be ’freely available’ in order to undergo the chemical reaction with the KF reagents.
Release of water from the sample
Karl Fischer titration is only possible if the water in the samples is freely available. This is not the case with solids if the water is bound as, e.g.:
- entrapped water
- water of crystallization (salts)
- capillary bounded water (e.g. in plants)
Thus, suitable sample preparations and special Karl Fischer methods are necessary to release water in these samples.
Karl Fischer Titration Guide. Part 2 — Sampe Preparation.
Table of contents
- 1 Release of Water from the Sample
- 1.1. Introduction
- 1.2 Internal extraction
- 1.3 External extraction
- 1.4 External dissolution
- 1.5 Lyophilized substance in septum bottles
- 1.6 Determination of water in gases
- 1.7 Determination using the drying oven
- 1.7.1 Principle
- 1.7.2 Purge gas
- 1.7.3 Procedure
- 1.7.4 Manual Karl Fischer drying oven
- 1.7.5 InMotion KF Oven Autosamplers
- 2 Further Information