Pharmaceutical Water Applications - METTLER TOLEDO

Pharmaceutical Water Applications

Pharmaceutical water measurement and control requirements have been drastically revised in the last decade. To maximize manufacturing efficiencies, the United States Pharmacopoeia (USP) developed new requirements for Water for Injection and for Purified Water in support of on-line conductivity, <645> and TOC <643> measurements. These requirements have enabled pharmaceutical manufacturers to provide real-time process controls, increase productivity and throughput, and support FDA's Process Analytical Technology (PAT) initiative.

USP initiated global HARMONIZATION efforts with the European Pharmacopoeia (EP), Japanese Pharmacopoeia (JP) and Chinese Pharmacopoeia (ChP) to help bring consistency to worldwide pharmaceutical water requirements. Mettler-Toledo Thornton is positioned as the global leader for HARMONIZATION activities for conductivity and TOC measurements.

Visit: In-line measurements for batch-to-batch consistency and quality

Pharmaceutical Water Applications
Pharmaceutical Water Applications

Applications

Applications

ORP Measurement in Pure Water
ORP is also used in other process and wastewater applications, including monitoring reducing conditions in power plant cycle chemistry, covered later...

Publications

Brochures

Pure Water Analytics A Step Ahead for Pharmaceutical Compliance
Topics covered in this brochure are: Pharmaceutical Water conductivity and Total Organic Carbon Requirements, instruments that meet USP Purified Water...

Competence Center

In-line measurements for batch-to-batch consistency and quality
To enable ideal growth conditions, batch-to-batch consistency and to achieve high yield and quality in Bio Pharmaceutical, Chemical Pharmaceutical pro...

Know-how

The Fundamental Conductivity and Resistivity of Water
The resistivity and conductivity of ultrapure water have been determined experimentally with particular emphasis on temperatures in the range 50 to 10...
A Continuous TOC Measurement Technology to Enhance Real-Time Process Control
This article discussses real time TOC tracking in the water purification process and the importance of rapid, continuous and reliable TOC monitoring f...
Advances in Instrumentation Used to Monitor High-Purity Water Treatment Systems
Water treatment trends including the development of different RO membrane materials, multiple pass systems, and CEDI require different measurement and...
Practical Application of Specific & Cation Conductivity Measurement
The basics of conductivity measurements used in steam power plants are reviewed and common pitfalls are examined with examples from actual installatio...
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