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Increasing worldwide demand for vaccines is resulting in manufacturers changing their production methods. Slow, chicken egg-based techniques are being replaced by much faster mammalian cell-culture fermentation. This white paper outlines vaccine manufacture based on biotechnology, and discusses the important role of the latest process analytical technology in maximizing production yield.
- how control of pH, dissolved oxygen, and dissolved CO2 levels affect mammalian cell culture productivity
- the importance of analytical measurements in downstream processes
- a recent development in sensor technology that increases fermentation process reliability