Glass Transition, Poly (D,L-lactide)-Co-Glycolide (DLPLGGLU)

Sample

Poly(D,L-lactide)-Co-Glycolide

Application

Biologically degradable polymer for implants

Conditions

Measuring cell: DSC821^e with IntraCooler

Pan: Aluminum 40 µl, hermetically sealed

Sample preparation: As received, no preparation

DSC measurement: Heating from 30 °C to 160 °C, then cooling to -60 °C, 10 minutes isothermally at -60 °C, then heating again to 160 °C, all steps with a heating or cooling rate of 10 K/min

Atmosphere: Nitrogen, 50 cm³/min

Interpretation

During the first heating run, thermal and mechanical relaxation occurs and eliminates the thermal history of the sample. In the second heating curve the glass transition and a low energy relaxation peak can be clearly seen.

Evaluation

Conclusion

The glass transition temperature is a function of the proportions of the two components in the polymer and is therefore a suitable criterion for use in quality control. For characterization purposes, only the second heating curve is normally used in order to ensure a standard thermal history before the actual measurement.

Glass Transition, Poly (D,L-lactide)-Co-Glycolide (DLPLGGLU) | Thermal Analysis Application No. HB810 | Application published in METTLER TOLEDO TA Application Handbook Pharmaceuticals