Sample Preparation – KF Titration | METTLER TOLEDO
Руководство

Sample Preparation for Water Content Determination

Руководство

Achieve Accurate Results by Preparing Your Samples According to How Water Is Bound

Easily acquire accurate results using the right preparation method for your sample
Easily acquire accurate results using the right preparation method for your sample

The Karl Fischer method is commonly used for water content determination in research and development, quality control and production monitoring. It is easily applied to a huge variety of samples in various industries, including potato chips or cheese in food and beverage manufacturing and aspirin or salicylic acid in pharmaceutical production.

However, water content determination through Karl Fischer titration is possible only if the water inside the samples is freely available. This is not the case with solids if the water is bound (e.g., as entrapped water, water of crystallization, or capillary-bound water). Thus, suitable sample preparations and special methods are necessary to correctly release water in these samples.

"Sample Preparation for Karl Fischer Titration” uses our expert knowledge of Karl Fischer titration to explain more advanced sample preparation procedures. This information will take you past simple sample dissolution in the titration cell to provide you with the most important know-how so you are able to achieve accurate results when performing water content determination by titration.

Download the titration guide now and apply these well-proven applications to your samples for quick, simple, and accurate water content titrations.

 

The guide series for Karl Fischer Titration includes the following content:

  • 1 Release of Water from the Sample
  • 1.1 Introduction
  • 1.2 Internal extraction
  • 1.3 External extraction
  • 1.4 External dissolution
  • 1.5 Lyophilized substance in septum bottles
  • 1.6 Determination of water in gases
  • 1.7 Determination using the drying oven
  • 1.7.1 Principle
  • 1.7.2 Purge gas
  • 1.7.3 Procedure
  • 1.7.4 Manual Karl Fischer drying oven
  • 1.7.5 InMotion KF Oven Autosamplers
  • 2 Further Information

This information will help you achieve accurate, repeatable titration results when performing the Karl Fischer water-content determination method.