Hydrogenation is one of the leading chemical reactions used because it allows the formation, in one single step, of C-C simple bonds from alkenes and alkynes, C-O bonds from ketones, aldehyde or esters and C-N (amines) from imines or nitriles.
Hydrogenation is influenced by several factors including type of catalyst, catalyst concentration, solvent, substrate purity, temperature and pressure. The optimization of a hydrogenation process requires selection of multiple parameters such as the correct catalyst, temperature, pressure, solvent, additives, and substrate-to-catalyst ratio.
By implementing hydrogenation technologies, scientists can achieve high productivity and volume efficiency, large reaction scope and high catalyst activity (low cost). Hydrogenation technologies have been developed to resolve key issues associated with the development, transfer and manufacturing of hydrogenation processes.
In situ FTIR analysis (ReactIR) provides continuous inline monitoring of hydrogenation processes in the lab, pilot plant and plant. Scientists use real time reaction information to determine reaction start and endpoints, reaction mechanisms and kinetics and chemical bond formation and breaking as well as tracking the formation of products and intermediates.
Synthesis workstations (EasyMax) provide precise control of temperature and other parameters to ensure highly reproducible experiments as well as developing robust processes at lab scale with knowledge about scalable parameters.
Hydrogenation Resources
- Mechanistic Insights into Anomalous Kinetic Behaviour in the Hydrogenation of a Substituted Nitrobenzene
- A Scale-Transparent Reaction Calorimetric Assay For Rapid Catalyst Selection
- Single Operation Stereoselective Synthesis of Aerangis Lactones: Combining Continuous Flow Hydrogenation and Biocatalysts in a Chemoenzymatic Sequence
- Evaluation of Raman Spectroscopy for Determining cis and trans Isomers in Partially Hydrogenated Soybean Oil
- Investigation of the Stability of the Corey−Kim Intermediate
- Online Mid-IR Spectroscopy as a Real-Time Approach in Monitoring Hydrogenation Reactions
- Online Spectroscopic Investigations (FTIR/Raman) of Industrial Reactions: Synthesis of Tributyltin Azide and Hydrogenation of Chloronitrobenzene
- Continuous-flow Catalytic Asymmetric Hydrogenations: Reaction Optimization using FTIR Inline Analysis
- A Combined Approach to Characterization of Catalytic Reactions using In Situ Kinetic Probes
- Study of the Hydrogenation of Selected Nitro Compounds by Simultaneous Measurements of Calorimetric, FTIR, and Gas-Uptake Signals
- Molybdenum Catalyzed Ethylene Carbonylation. II. Spectroscopic Investigation of the Reactions and Equilibria of Molybdenum Hexacarbonyl and Molybdenum Halocarbonyls under Reaction Conditions
- Iridium-Catalyzed Enantioselective Hydrogenation of Imines in Supercritical Carbon Dioxide
- Determination of the Endpoint of a Chemical Synthesis Process Using Online Measured Mid-Infrared Spectra
- Dynamic Modelling of Consecutive Reactions: Application to the Acrylonitrile Amination
- The Role of Reaction Calorimetry in the Development and Scale-up of Aromatic Nitrations
Biblioteka
On-Demand Webinars
This presentation discusses the implementation of Fourier Transform Infrared (FTIR) reaction monitoring technology to provide knowledge and understand...
This webinar discusses how to perform safe scale-up of chemical processes and includes a close examination of thermal risks and hazards.
White Papers
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Produkty pokrewne
ReactIR
Spektrometry in situ FTIR umożliwiają naukowcom uzyskanie wglądu w reakcje i procesy w wielu różnych zastosowaniach. Optymalizacja zmiennych reakcji przy użyciu wbudowanych urządze...
Kalorymetr reakcyjny
Kalorymetry reakcyjne są stosowane w opracowywaniu produktów chemicznych oraz farmaceutycznych i mierzą energię uwolnioną lub pochłoniętą w czasie reakcji.
Automatyczny system pobierania próbek
Automatyczne systemy pobierania próbek do reaktorów chemicznych pobierają niezawodne próbki analityczne na linii produkcyjnej oraz umożliwiają wygaszanie in situ i rozcieńczanie, a...