Chemical Synthesis | Lab Instruments, Automation

Chemical Synthesis

Producing Quality, Economically-Viable Molecules

Spectrometers for Chemical Synthesis

Aplikacje

Synthetic Organic Chemistry Applications

Control Residual Isocyanate
Process Analytical Technology for Continuous Measurement of NCO

Isocyanates are critical building blocks for high performance polyurethane-based polymers that make up coatings, foams, adhesives, elastomers, and insulation. Concerns over exposure to residual isocyanates led to new limits for residual isocyanates in new products. Traditional analytical methods for measuring the residual isocyanate (NCO) concentration using offline sampling and analysis raise concerns. In situ monitoring with process analytical technology addresses these challenges and enables manufacturers and formulators to ensure that product quality specifications, personnel safety, and environmental regulations are met.

Synteza polimerów
Obserwacja w czasie rzeczywistym reakcji polimeryzacji

Obserwacja w czasie rzeczywistym reakcji polimeryzacji

Impurity Profiling of Chemical Reactions
Automated Drug Development Strategies for Chemists

Knowledge of impurity kinetics and mechanism of formation is important in determining reaction end-point in chemical and process development studies. Accurate, reproducible, and representative reactions samples are necessary for these studies.

Chemical Reaction Kinetics Studies
Study Chemical Reaction Rates and Measure Kinetics Inline

In situ chemical reaction kinetics studies provide an improved understanding of reaction mechanism and pathway by providing concentration dependences of reacting components in real-time. Continuous data over the course of a reaction allows for the calculation of rate laws with fewer experiments due to the comprehensive nature of the data.  Reaction Progression Kinetics Analysis (RPKA) uses in situ data under synthetically relevant concentrations and captures information throughout the whole experiment ensuring that the complete reaction behavior can be accurately described.

Procesy chemiczne prowadzone w przepływie
Skróć czas trwania procesów prowadzonych cyklicznie, popraw jakość i zwiększ wydajność

Skróć czas trwania procesów prowadzonych cyklicznie, popraw jakość i zwiększ wydajność.

Grignard
Grignard Reagents in Chemical Synthesis

Monitor and Control Synthesis of Grignard Reagents

Uwodornienie
Characterize Effects of Reaction Variables With Hydrogenation

Hydrogenation is one of the leading chemical reactions used because it allows the formation, in one single step, of C-C simple bonds from alkenes and alkynes, C-O bonds from ketones, aldehyde or esters and C-N (amines) from imines or nitriles.

Reakcje pod wysokim ciśnieniem
Understand and Characterize High Pressure Reactions Under Challenging Sampling Conditions

Many processes require reactions to be run under high pressure. Working under pressure is challenging and collecting samples for offline analysis is difficult and time consuming. A change in pressure could affect reaction rate, conversion and mechanism as well as other process parameters plus sensitivity to oxygen, water, and associated safety issues are common problems.

Hydroformylacja lub synteza/proces okso
Understand Catalyst Activity

Hydroformylation, or oxo synthesis/process, is important for the production of olefins to aldehydes and aldehydes from alkenes. Hydroformylation reactions are performed at high pressure and can be challenging to sample due to the extreme reaction conditions, as well as the toxic, flammable, and reactive raw materials and reagents.

Catalytic Reactions
Accelerate Chemical Reactions With a Catalyst

Catalysts create an alternative path to increase the speed and outcome of a reaction, so a thorough understanding of the reaction kinetics is important. Not only does that provide information about the rate of the reaction, but also provides insight into the mechanism of the reaction. There are two types of catalytic reactions: heterogeneous and homogeneous. Heterogeneous is when the catalyst and reactant exist in two different phases. Homogeneous is when the catalyst and the reactant are in the same phase..

reakcje syntezy
Zapewnienie ważnych cząstek na potrzeby badań, przemysłu i handlu

Synteza, jako jeden z czterech głównych typów reakcji chemicznych, jest reprezentowana przez ważne przykłady w chemii organicznej, katalitycznej, polimeryzacji i chemii nieorganicznej/metaloorganicznej. W najprostszym przypadku reakcja syntezy zachodzi, gdy dwie cząsteczki łączą się, tworząc trzecią bardziej złożoną cząsteczkę produktu. Zazwyczaj reakcje te są bardziej złożone i wymagają dokładnego zrozumienia kinetyki i mechanizmów leżących u podstaw chemii, a także starannie kontrolowanych warunków reakcji.

Projektowanie eksperymentów (DoE)
Podejście statystyczne do optymalizacji reakcji

Projektowanie eksperymentów (DoE) w celu optymalizacji procesów chemicznych wymaga przeprowadzania eksperymentów w dobrze kontrolowanych i powtarzalnych warunkach. Reaktory syntezy chemicznej zostały zaprojektowane do przeprowadzania badań DoE z zachowaniem wysokiej jakości danych.

Understand the structure of individual molecules and composition of molecular mixtures

Fourier Transform Infrared (FTIR) Spectroscopy For Real-Time Monitoring Of Chemical Reactions

Reaction Mechanism Pathway
Fundamental Understanding of Chemical Reactions and Factors Affecting Them

Reaction mechanisms describe the successive steps at the molecular level that take place in a chemical reaction. Reaction mechanisms cannot be proven, but rather postulated based on empirical experimentation and deduction. In situ FTIR spectroscopy provides information to support reaction mechanisms hypotheses.

Organometallic Synthesis
Understanding and Control of Organometallic Compounds

Organometallic Synthesis, or Organometallic Chemistry, refers to the process of creating organometallic compounds, and is among the most researched areas in chemistry. Organometallic compounds are frequently used in fine chemical syntheses and to catalyze reactions. In situ Infrared and Raman spectroscopy are among the most powerful analytical methods for the study of organometallic compounds and syntheses.

Ensure Yield, Purity, and Cost Objectives

Oligonucleotide synthesis is the chemical process by which nucleotides are specifically linked to form a desired sequenced product. The repetitive cyclic nature of the synthesis used in producing these biopolymers requires careful control of reaction variables, as well as step-wise reaction tracking and purity assurance to ensure that the desired sequence is attained. PAT methodology supports the development and production of these important biomolecules.

For Key Reactions in Organic Chemistry

Alkylation is the process by when an alkyl group is added to a substrate molecule. There are many different alkylating reagents and types of alkylating reactions, and thus it is a widely used technique in organic chemistry. Alkylation is important for manufacturing in the petroleum and commodity chemicals industries, as well as in medicine, since many chemotherapy drugs are alkylating agents. The breadth of reaction types, conditions, and the economic importance of alkylation necessitates thorough understanding, control, and monitoring of alkylation reactions.

Key Functional Groups for Synthesis of Polymers and Pharmaceuticals

Epoxides are three member ethers having a highly strained ring structure containing two carbons and an oxygen. Because of the strain in this structure, epoxides are quite reactive and represent a valuable functional group for performing a variety of reactions. Due to this, epoxides are useful in polymer, pharmaceutical, and fine chemical syntheses.

Key C-C Bond-Forming Reactions in Molecular Synthesis

The Suzuki and related cross-coupling reactions use transition metal catalysts, such as palladium complexes, to form C-C bonds between alkyl and aryl halides with various organic compounds. These catalyzed reactions are widely used methods to efficiently increase molecular complexity in pharmaceutical, polymer, and natural product syntheses. PAT technology is used to investigate cross-coupled reactions with regard to kinetics, mechanisms, thermodynamics, and the effect of reaction variables on performance and safety.

New Business Realities Call for a New Kind of Laboratory

Key Reagents for Synthesizing Complex Molecules

Lithiation and organolithium reactions are key in the development of complex pharmaceutical compounds. Also, organolithium compounds act as initiators in certain polymerization reactions. The exceptional reactivity of organolithium reagents result from the strong polarity of the C-Li bond, making these reactions and family of compounds among the most important in industrial applications. In situ ReactIR technology has proven useful for investigating lithiations and organolithium reactions in both batch and continuous flow applications.

Control Residual Isocyanate

Isocyanates are critical building blocks for high performance polyurethane-based polymers that make up coatings, foams, adhesives, elastomers, and insulation. Concerns over exposure to residual isocyanates led to new limits for residual isocyanates in new products. Traditional analytical methods for measuring the residual isocyanate (NCO) concentration using offline sampling and analysis raise concerns. In situ monitoring with process analytical technology addresses these challenges and enables manufacturers and formulators to ensure that product quality specifications, personnel safety, and environmental regulations are met.

Synteza polimerów

Obserwacja w czasie rzeczywistym reakcji polimeryzacji

Impurity Profiling of Chemical Reactions

Knowledge of impurity kinetics and mechanism of formation is important in determining reaction end-point in chemical and process development studies. Accurate, reproducible, and representative reactions samples are necessary for these studies.

Chemical Reaction Kinetics Studies

In situ chemical reaction kinetics studies provide an improved understanding of reaction mechanism and pathway by providing concentration dependences of reacting components in real-time. Continuous data over the course of a reaction allows for the calculation of rate laws with fewer experiments due to the comprehensive nature of the data.  Reaction Progression Kinetics Analysis (RPKA) uses in situ data under synthetically relevant concentrations and captures information throughout the whole experiment ensuring that the complete reaction behavior can be accurately described.

Procesy chemiczne prowadzone w przepływie

Skróć czas trwania procesów prowadzonych cyklicznie, popraw jakość i zwiększ wydajność.

Grignard

Monitor and Control Synthesis of Grignard Reagents

Uwodornienie

Hydrogenation is one of the leading chemical reactions used because it allows the formation, in one single step, of C-C simple bonds from alkenes and alkynes, C-O bonds from ketones, aldehyde or esters and C-N (amines) from imines or nitriles.

Reakcje pod wysokim ciśnieniem

Many processes require reactions to be run under high pressure. Working under pressure is challenging and collecting samples for offline analysis is difficult and time consuming. A change in pressure could affect reaction rate, conversion and mechanism as well as other process parameters plus sensitivity to oxygen, water, and associated safety issues are common problems.

Hydroformylacja lub synteza/proces okso

Hydroformylation, or oxo synthesis/process, is important for the production of olefins to aldehydes and aldehydes from alkenes. Hydroformylation reactions are performed at high pressure and can be challenging to sample due to the extreme reaction conditions, as well as the toxic, flammable, and reactive raw materials and reagents.

Catalytic Reactions

Catalysts create an alternative path to increase the speed and outcome of a reaction, so a thorough understanding of the reaction kinetics is important. Not only does that provide information about the rate of the reaction, but also provides insight into the mechanism of the reaction. There are two types of catalytic reactions: heterogeneous and homogeneous. Heterogeneous is when the catalyst and reactant exist in two different phases. Homogeneous is when the catalyst and the reactant are in the same phase..

reakcje syntezy

Synteza, jako jeden z czterech głównych typów reakcji chemicznych, jest reprezentowana przez ważne przykłady w chemii organicznej, katalitycznej, polimeryzacji i chemii nieorganicznej/metaloorganicznej. W najprostszym przypadku reakcja syntezy zachodzi, gdy dwie cząsteczki łączą się, tworząc trzecią bardziej złożoną cząsteczkę produktu. Zazwyczaj reakcje te są bardziej złożone i wymagają dokładnego zrozumienia kinetyki i mechanizmów leżących u podstaw chemii, a także starannie kontrolowanych warunków reakcji.

Projektowanie eksperymentów (DoE)

Projektowanie eksperymentów (DoE) w celu optymalizacji procesów chemicznych wymaga przeprowadzania eksperymentów w dobrze kontrolowanych i powtarzalnych warunkach. Reaktory syntezy chemicznej zostały zaprojektowane do przeprowadzania badań DoE z zachowaniem wysokiej jakości danych.

Fourier Transform Infrared (FTIR) Spectroscopy For Real-Time Monitoring Of Chemical Reactions

Reaction Mechanism Pathway

Reaction mechanisms describe the successive steps at the molecular level that take place in a chemical reaction. Reaction mechanisms cannot be proven, but rather postulated based on empirical experimentation and deduction. In situ FTIR spectroscopy provides information to support reaction mechanisms hypotheses.

Organometallic Synthesis

Organometallic Synthesis, or Organometallic Chemistry, refers to the process of creating organometallic compounds, and is among the most researched areas in chemistry. Organometallic compounds are frequently used in fine chemical syntheses and to catalyze reactions. In situ Infrared and Raman spectroscopy are among the most powerful analytical methods for the study of organometallic compounds and syntheses.

Oligonucleotide synthesis is the chemical process by which nucleotides are specifically linked to form a desired sequenced product. The repetitive cyclic nature of the synthesis used in producing these biopolymers requires careful control of reaction variables, as well as step-wise reaction tracking and purity assurance to ensure that the desired sequence is attained. PAT methodology supports the development and production of these important biomolecules.

Alkylation is the process by when an alkyl group is added to a substrate molecule. There are many different alkylating reagents and types of alkylating reactions, and thus it is a widely used technique in organic chemistry. Alkylation is important for manufacturing in the petroleum and commodity chemicals industries, as well as in medicine, since many chemotherapy drugs are alkylating agents. The breadth of reaction types, conditions, and the economic importance of alkylation necessitates thorough understanding, control, and monitoring of alkylation reactions.

Epoxides are three member ethers having a highly strained ring structure containing two carbons and an oxygen. Because of the strain in this structure, epoxides are quite reactive and represent a valuable functional group for performing a variety of reactions. Due to this, epoxides are useful in polymer, pharmaceutical, and fine chemical syntheses.

The Suzuki and related cross-coupling reactions use transition metal catalysts, such as palladium complexes, to form C-C bonds between alkyl and aryl halides with various organic compounds. These catalyzed reactions are widely used methods to efficiently increase molecular complexity in pharmaceutical, polymer, and natural product syntheses. PAT technology is used to investigate cross-coupled reactions with regard to kinetics, mechanisms, thermodynamics, and the effect of reaction variables on performance and safety.

Lithiation and organolithium reactions are key in the development of complex pharmaceutical compounds. Also, organolithium compounds act as initiators in certain polymerization reactions. The exceptional reactivity of organolithium reagents result from the strong polarity of the C-Li bond, making these reactions and family of compounds among the most important in industrial applications. In situ ReactIR technology has proven useful for investigating lithiations and organolithium reactions in both batch and continuous flow applications.

Biblioteka

Publications on Synthetic Organic Chemistry

White Papers

Techniki syntezowania przełomowych molekuł
Postęp w chemii organicznej pozwala naukowcom prowadzić badania nad nowymi związkami organicznymi oraz optymalizować warunki prowadzenia procesów. W n...
synteza chemiczna bez kolby okrągłodennej
Learn how to improve your organic synthesis!This white paper discusses new methodologies for organic synthesis including how to: Cool and heat without...
Optymalizuj reakcje katalizowane przez metale
Jakość wielu reakcji, szczególnie w obszarze analizy reakcji, zależy w znacznym stopniu od możliwości określenia punktu początkowego i końcowego. Opra...
Skuteczniejsze monitorowanie reakcji chemicznych
'W jaki sposób można osiągnąć więcej, dysponując mniejszymi zasobami?'. Jest to wciąż powracające pytanie w laboratoriach zajmujących się opracowaniem...
Zastosowanie technik kontroli procesów FTIR do zapewnienia bezpieczeństwa w procesie redukcji borowodorku sodu
John O'Reilly z firmy Roche Ireland omawia zastosowanie dającej powtarzalne wyniki technologii analizy procesów PAT oraz techniki kontroli procesów FT...
Przewodnik o monitorowaniu reakcji w czasie rzeczywistym: jednoczesna hydroformylacja/uwodornienie
Monitorowanie reakcji w czasie rzeczywistym w warunkach in situ przy pomocy techniki mid-FTIR pozwala lepiej zrozumieć aktywność i odporność katalizat...
skalowanie reakcji Grignarda – 4 etapy kontroli rozwoju
Egzotermiczne reakcje chemiczne niosą ze sobą duże ryzyko – ryzyko to jest szczególnie wysokie na etapie skalowania tych reakcji. Z badań opublikowan...
Szybka analiza eksperymentów ze stałym optymalizowaniem reakcji
W opracowaniu technicznym „Szybka analiza eksperymentów ze stałym optymalizowaniem reakcji” omówiono metody optymalizowania reakcji chemicznych.
3 Reaction Monitoring Case Studies
In this whitepaper, three case studies carried out at GlaxoSmithKline (GSK) demonstrate how probe-based and real-time FTIR instrumentation helped to c...
Nowoczesne laboratorium syntezy
W tym przewodniku omówiono nowy zestaw narzędzi przeznaczony specjalnie dla chemików, który oferuje dodatkowe możliwości w pracach doświadczalnych ora...
Profilowanie reakcji chemicznych: omówienie literatury
W przewodniku „Profilowanie reakcji chemicznych: omówienie literatury” opisano 20 przypadków zastosowania spektroskopii FTIR in situ do kompleksowych...
Wgląd w reakcje po każdym eksperymencie
W tym przewodniku przedstawiamy pięć przykładów opisanych w artykułach niedawno opublikowanych przez czasopisma, w których metoda HPLC okazała się nie...

Webinars

Hydrogenation Under High Pressure
This presentation discusses the implementation of Fourier Transform Infrared (FTIR) reaction monitoring technology to provide knowledge and understand...
Opracowywanie procesów chemicznych w firmie Merck
Shane Grosser wyjaśnia, w jaki sposób laboratorium intensyfikacji rozwoju procesów firmy Merck tworzy nowe narzędzia i metody, które przyspieszają opr...
Reaction Kinetics Progress Analysis Ryan Baxter
W trakcie seminarium omawiane jest nowe podejście wykorzystujące analizę graficzną do usprawnienia kinetyki aktywacji wiązań C-H. Omówiono metodologi...
Hydrogenation Under High Pressure
This presentation discusses the implementation of Fourier Transform Infrared (FTIR) reaction monitoring technology to provide knowledge and understand...
DoE to Peptide Synthesis
Learn how Design of Experiments (DoE) is applied to chemical synthesis at Lonza Peptide.
New Radical Reactions Enabled by In Situ Reaction Monitoring
Presented by Professor Ryan Baxter of the University of California-Merced, this on-demand webinar discusses research that involved new radical reactio...
Process Development and Kinetic Understanding
Presented by Eric Moschetta, this on-demand webinar describes how AbbVie built a robust kinetic model to understand a late stage API process
Alkylation Reaction Development
Kevin Stone discusses how Merck Chemical Engineering Research & Development (CERD) leverages process fingerprinting tools in the development of an Alk...

Produkty pokrewne

Synthetic Organic Chemistry Tools

Thank you for visiting www.mt.com. We have tried to optimize your experience while on the site, but we noticed that you are using an older version of a web browser. We would like to let you know that some features on the site may not be available or may not work as nicely as they would on a newer browser version. If you would like to take full advantage of the site, please update your web browser to help improve your experience while browsing www.mt.com.