Chemical Process Development & Scale-up
Chemical Process Development & Scale-Up

Chemical Process Development & Scale-Up

Design Robust and Sustainable Chemical Processes For Faster Transfer To Pilot Plant and Production

Applikasjoner

Chemical Process Development and Scale-up Applications

Heat Transfer and Process Scale-up
How Heat Transport in Agitated Vessels Affects Process Scale-up

Scaling-up a chemical process from lab to manufacturing gives useful results only with accurate heat transfer coefficients. Measuring the jacket and reactor temperature (during the release of a well-defined amount of heat) allows researchers to accurately compute the thermal resistance which is used to model the heat transfer and make critical predictions for reactors at larger scale. Reaction calorimetry is essential to determine parameters that impact the heat transfer and the heat transfer coefficients to develop models to maximize the bandwidth of a manufacturing plant. 

Mass Transfer and Reaction Rate
Mixing in a Chemical Reactor and the Effect on Reaction Kinetics and Scale-up

Mixing is the reduction or elimination of inhomogeneity of phases that are either miscible or immiscible. Process scale-up and optimization require that the impact of mixing on the reaction rate be quantified. Automated, controlled experiments can be run in parallel in a laboratory reactor system to establish a mass transfer correlation, and provide a means to quickly adjust the gas/ liquid interface area and reactor volume. This achieves the desired conditions required for the scale-up or scale-down of a process.

Organisk syntese
Filtrer og optimer katalyse, hydrogenisering, polymersyntetisering og andre reaktive kjemiske synteser

Kjemikere som jobber med syntetisk organisk kjemi oppdager og utvikler innovative kjemiske reaksjoner og prosesser.

Krystallisering og utfelling
Optimer krystallstørrelse, utvinning og renhet

Optimering og oppskalering av krystallisering og utfelling for å produsere et produkt som konsekvent overholder målene for renhet, resultat, form og partikkelstørrelse kan være en av de største utfordringene for prosessutvikling.

kjemisk reaksjonskinetikk
Study Chemical Reaction Rates and Measure Kinetics Inline

kjemisk prosessikkerhet
Bestem sikkerheten for kjemiske prosesser før oppskalering

Temperature Effects Crystallization Size and Shape
Scaling-Up Agitation, Dosing, and Crystallization

Changing the scale or mixing conditions in a crystallizer can directly impact the kinetics of the crystallization process and the final crystal size. Heat and mass transfer effects are important to consider for cooling and antisolvent systems respectively, where temperature or concentration gradients can produce inhomogeneity in the prevailing level of supersaturation.

Heat Transfer and Process Scale-up

Scaling-up a chemical process from lab to manufacturing gives useful results only with accurate heat transfer coefficients. Measuring the jacket and reactor temperature (during the release of a well-defined amount of heat) allows researchers to accurately compute the thermal resistance which is used to model the heat transfer and make critical predictions for reactors at larger scale. Reaction calorimetry is essential to determine parameters that impact the heat transfer and the heat transfer coefficients to develop models to maximize the bandwidth of a manufacturing plant. 

Mass Transfer and Reaction Rate

Mixing is the reduction or elimination of inhomogeneity of phases that are either miscible or immiscible. Process scale-up and optimization require that the impact of mixing on the reaction rate be quantified. Automated, controlled experiments can be run in parallel in a laboratory reactor system to establish a mass transfer correlation, and provide a means to quickly adjust the gas/ liquid interface area and reactor volume. This achieves the desired conditions required for the scale-up or scale-down of a process.

Organisk syntese

Kjemikere som jobber med syntetisk organisk kjemi oppdager og utvikler innovative kjemiske reaksjoner og prosesser.

Krystallisering og utfelling

Optimering og oppskalering av krystallisering og utfelling for å produsere et produkt som konsekvent overholder målene for renhet, resultat, form og partikkelstørrelse kan være en av de største utfordringene for prosessutvikling.

Temperature Effects Crystallization Size and Shape

Changing the scale or mixing conditions in a crystallizer can directly impact the kinetics of the crystallization process and the final crystal size. Heat and mass transfer effects are important to consider for cooling and antisolvent systems respectively, where temperature or concentration gradients can produce inhomogeneity in the prevailing level of supersaturation.

Publikasjoner

Publications Related to Chemical Process Development and Scale-up

White Papers and Guides

Risks From Rising Temperature
In chemical process scale-up, understanding temperature change and the associated heat that is accumulated by the reaction are critical to process saf...
Effective Design of Experiment Studies
This paper describes the Design of Experiments (DoE) approach and how it is used to identify the relationship between parameters, defining optimal set...
Safe, Unattended Dosing in Chemical Development & Scale-up
Grünenthal Process R&D safely automates dosing and runs highly exothermic reactions unattended to increase productivity without additional staff.
Techniques to Synthesize Breakthrough Molecules
Advances in organic chemistry allow researchers to expand R&D of molecules and optimize process conditions. A new white paper presents 4 case studies...
Veiledning for reaksjonskalorimetri
Reaksjonskalorimetri gir en forståelse for kjemiske prosesser og er en kilde til sikkerhet og oppskaleringsinformasjon. Reaksjonskalorimetre avgjør hv...

Citations

ReactIR Citation List
Continuous measurements from infrared spectroscopy are widely used for obtaining reaction profiles, which are used to calculate reaction rates. This...

Relaterte produkter

Products For Process Development and Scale-up

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