Design of Experiments (DoE) is a statistical approach to reaction and process optimization that permits the variation of different factors simultaneously with the goal to screen the reaction space for optimum values.
In chemical development, Design of Experiments (DoE) has become a reference method to speed up reaction optimization, since it allows the assessment of a large number of reaction parameters in a small number of experiments. Over the last several years, DoE has been used for the implementation of Quality by Design (QbD) in R&D and manufacturing. In Pharmaceutical QbD, product and process understanding is critical for ensuring quality in the manufactured product.