Chemical Synthesis | Lab Instruments, Automation

Chemical Synthesis

Producing Quality, Economically-Viable Molecules

Spectrometers for Chemical Synthesis

Applicaties

Synthetic Organic Chemistry Applications

Control Residual Isocyanate
Process Analytical Technology for Continuous Measurement of NCO

Isocyanates are critical building blocks for high performance polyurethane-based polymers that make up coatings, foams, adhesives, elastomers, and insulation. Concerns over exposure to residual isocyanates led to new limits for residual isocyanates in new products. Traditional analytical methods for measuring the residual isocyanate (NCO) concentration using offline sampling and analysis raise concerns. In situ monitoring with process analytical technology addresses these challenges and enables manufacturers and formulators to ensure that product quality specifications, personnel safety, and environmental regulations are met.

Measuring Polymerization Reactions
Methods and Techniques to Develop Synthetic Polymer Chemistry

Polymerization reaction measurement is crucial to produce material that meets requirements, including Immediate understanding, accurate and reproducible, Improved safety.

Impurity Profiling of Chemical Reactions
Automated Process Development Strategies for Chemists

Impurity profiling aims at identification and subsequent quantification of specific components present at low levels, usually less than 1% and ideally lower than 0.1 %.

Chemical Reaction Kinetics Studies
Fundamental Understanding of Reactions Rates and Factors Affecting Them

Chemical reaction kinetics, also known as reaction kinetics, reflect rates of chemical reactions and provide a better understanding of their dependencies on reaction variables. Reaction kinetic studies provide enhanced insight into reaction mechanisms. Learn how to obtain data rich information for more complete reaction kinetic information.

Continue Flow Chemie
Verkort de cyclustijd en verhoog de kwaliteit en opbrengsten dankzij Flow Chemie.

Verkort de cyclustijd en verhoog de kwaliteit en opbrengst dankzij continue flow chemie

Grignard Reaction Mechanisms
Understand and Control Exothermic Events

Grignard reactions are one of the most important reaction classes in organic chemistry. Grignard reactions are useful for forming carbon-carbon bonds. Grignard reactions form alcohols from ketones and aldehydes, as well as react with other chemicals to form a myriad of useful compounds. Grignard reactions are performed using a Grignard reagent, which is typically a alkyl-, aryl- or vinyl- organomagnesium halide compound. To ensure optimization and safety of Grignard reactions in research, development and production, in situ monitoring and understanding reaction heat flow is important.

Hydrogenation Reactions
Safe Reaction Monitoring at Elevated Temperature and Pressure

Hydrogenation reactions are used in the manufacturing of both bulk and fine chemicals for reducing multiple bonds to single bonds. Catalysts are typically used to promote these reactions and reaction temperature, pressure, substrate loading, catalyst loading, and agitation rate all effect hydrogen gas uptake and overall reaction performance. Thorough understanding of this energetic reaction is important and PAT technology in support of HPLC analysis ensure safe, optimized and well-characterized chemistry.

Highly Reactive Chemistries
Scale-Up and Optimize Highly Reactive Chemistries

Highly reactive chemistry is a terminology used to describe chemical reactions that are particularly challenging to handle and develop due to the potentially hazardous and/or energetic nature of the reactants, intermediates and products that are present during synthesis. These chemistries often involve highly exothermic reactions which require specialized equipment or extreme operating conditions (such as low temperature) to ensure adequate control. Ensuring safe operating conditions, minimizing human exposure, and gaining the maximum amount of information from each experiment are key factors in successfully designing and scaling-up highly reactive chemistries.

High Pressure Reactions
Understand and Characterize High Pressure Reactions Under Challenging Sampling Conditions

Many processes require reactions to be run under high pressure. Working under pressure is challenging and collecting samples for offline analysis is difficult and time consuming. A change in pressure could affect reaction rate, conversion and mechanism as well as other process parameters plus sensitivity to oxygen, water, and associated safety issues are common problems.

Hydroformylation or Oxo Synthesis/Process
Understanding Key Mechanisms and Improve Catalytic Processes

Hydroformylation, or oxo synthesis, catalytic processes that synthesize aldehydes from alkenes. The resultant aldehydes form the feedstock for many other useful organic compounds.

Halogenation Reactions
Key Syntheses in Pharmaceutical and Polymer Chemistry

Halogenation occurs when one of more fluorine, chlorine, bromine, or iodine atoms replace one or more hydrogen atoms in an organic compound. Depending on the specific halogen, the nature of the substrate molecule and overall reaction conditions, halogenation reactions can be very energetic and follow different pathways. For this reason, understanding these reactions from a kinetics and thermodynamic perspective is critical to ensuring yield, quality and safety of the process.

Catalytic Reactions
Accelerate Chemical Reactions With a Catalyst

Catalysts create an alternative path to increase the speed and outcome of a reaction, so a thorough understanding of the reaction kinetics is important. Not only does that provide information about the rate of the reaction, but also provides insight into the mechanism of the reaction. There are two types of catalytic reactions: heterogeneous and homogeneous. Heterogeneous is when the catalyst and reactant exist in two different phases. Homogeneous is when the catalyst and the reactant are in the same phase..

synthesis reactions
Providing Automated Tools to Deliver Life Changing Products

One of the four major classes of chemical reactions, synthesis reactions are represented by important examples in organic synthesis, catalyzed chemistry, polymerizations and inorganic/organometallic chemistry. In the simplest case, a synthesis reaction occurs when two molecules combine to form a third, more complex product molecule. Often, synthesis reactions are more complex and require a thorough understanding of the kinetics and mechanisms of the underlying chemistry, as well as carefully controlled reaction conditions.

Design of Experiments (DoE)
A Statistical Approach to Reaction Optimization

Design of Experiments (DoE) requires experiments to be conducted under well-controlled and reproducible conditions in chemical process optimization. Chemical synthesis reactors are designed to perform DoE investigations ensuring high quality data.

Understand the structure of individual molecules and composition of molecular mixtures

Fourier Transform Infrared (FTIR) Spectroscopy For Real-Time Monitoring Of Chemical Reactions

Reaction Mechanism Pathway
Fundamental Understanding of Chemical Reactions and Factors Affecting Them

Reaction mechanisms describe the successive steps at the molecular level that take place in a chemical reaction. Reaction mechanisms cannot be proven, but rather postulated based on empirical experimentation and deduction. In situ FTIR spectroscopy provides information to support reaction mechanisms hypotheses.

Organometallic Synthesis
Understanding and Control of Organometallic Compounds

Organometallic Synthesis, or Organometallic Chemistry, refers to the process of creating organometallic compounds, and is among the most researched areas in chemistry. Organometallic compounds are frequently used in fine chemical syntheses and to catalyze reactions. In situ Infrared and Raman spectroscopy are among the most powerful analytical methods for the study of organometallic compounds and syntheses.

Oligonucleotide Synthesis
Ensure Yield, Purity, and Cost Objectives

Oligonucleotide synthesis is the chemical process by which nucleotides are specifically linked to form a product of desired sequenced.

What is Alkylation?
For Key Reactions in Organic Chemistry

Alkylation is the process by when an alkyl group is added to a substrate molecule. Alkylation is a widely used technique in organic chemistry.

Epoxides
Key Functional Groups for Synthesis of Polymers and Pharmaceuticals

This page outlines what epoxides are, how they are synthesized and technology to track reaction progression, including kinetics and key mechanisms.

Key C-C Bond-Forming Reactions in Molecular Synthesis

The Suzuki and related cross-coupling reactions use transition metal catalysts, such as palladium complexes, to form C-C bonds between alkyl and aryl halides with various organic compounds. These catalyzed reactions are widely used methods to efficiently increase molecular complexity in pharmaceutical, polymer, and natural product syntheses. PAT technology is used to investigate cross-coupled reactions with regard to kinetics, mechanisms, thermodynamics, and the effect of reaction variables on performance and safety.

Lithiation Organolithium Reactions
Key Reagents for Synthesizing Complex Molecules

Lithiation and organolithium reactions are key in the development of complex pharmaceutical compounds; organolithium compounds also act as initiators in certain polymerization reactions.

Control Residual Isocyanate

Isocyanates are critical building blocks for high performance polyurethane-based polymers that make up coatings, foams, adhesives, elastomers, and insulation. Concerns over exposure to residual isocyanates led to new limits for residual isocyanates in new products. Traditional analytical methods for measuring the residual isocyanate (NCO) concentration using offline sampling and analysis raise concerns. In situ monitoring with process analytical technology addresses these challenges and enables manufacturers and formulators to ensure that product quality specifications, personnel safety, and environmental regulations are met.

Measuring Polymerization Reactions

Polymerization reaction measurement is crucial to produce material that meets requirements, including Immediate understanding, accurate and reproducible, Improved safety.

Impurity Profiling of Chemical Reactions

Impurity profiling aims at identification and subsequent quantification of specific components present at low levels, usually less than 1% and ideally lower than 0.1 %.

Chemical Reaction Kinetics Studies

Chemical reaction kinetics, also known as reaction kinetics, reflect rates of chemical reactions and provide a better understanding of their dependencies on reaction variables. Reaction kinetic studies provide enhanced insight into reaction mechanisms. Learn how to obtain data rich information for more complete reaction kinetic information.

Continue Flow Chemie

Verkort de cyclustijd en verhoog de kwaliteit en opbrengst dankzij continue flow chemie

Grignard Reaction Mechanisms

Grignard reactions are one of the most important reaction classes in organic chemistry. Grignard reactions are useful for forming carbon-carbon bonds. Grignard reactions form alcohols from ketones and aldehydes, as well as react with other chemicals to form a myriad of useful compounds. Grignard reactions are performed using a Grignard reagent, which is typically a alkyl-, aryl- or vinyl- organomagnesium halide compound. To ensure optimization and safety of Grignard reactions in research, development and production, in situ monitoring and understanding reaction heat flow is important.

Hydrogenation Reactions

Hydrogenation reactions are used in the manufacturing of both bulk and fine chemicals for reducing multiple bonds to single bonds. Catalysts are typically used to promote these reactions and reaction temperature, pressure, substrate loading, catalyst loading, and agitation rate all effect hydrogen gas uptake and overall reaction performance. Thorough understanding of this energetic reaction is important and PAT technology in support of HPLC analysis ensure safe, optimized and well-characterized chemistry.

Highly Reactive Chemistries

Highly reactive chemistry is a terminology used to describe chemical reactions that are particularly challenging to handle and develop due to the potentially hazardous and/or energetic nature of the reactants, intermediates and products that are present during synthesis. These chemistries often involve highly exothermic reactions which require specialized equipment or extreme operating conditions (such as low temperature) to ensure adequate control. Ensuring safe operating conditions, minimizing human exposure, and gaining the maximum amount of information from each experiment are key factors in successfully designing and scaling-up highly reactive chemistries.

High Pressure Reactions

Many processes require reactions to be run under high pressure. Working under pressure is challenging and collecting samples for offline analysis is difficult and time consuming. A change in pressure could affect reaction rate, conversion and mechanism as well as other process parameters plus sensitivity to oxygen, water, and associated safety issues are common problems.

Hydroformylation or Oxo Synthesis/Process

Hydroformylation, or oxo synthesis, catalytic processes that synthesize aldehydes from alkenes. The resultant aldehydes form the feedstock for many other useful organic compounds.

Halogenation Reactions

Halogenation occurs when one of more fluorine, chlorine, bromine, or iodine atoms replace one or more hydrogen atoms in an organic compound. Depending on the specific halogen, the nature of the substrate molecule and overall reaction conditions, halogenation reactions can be very energetic and follow different pathways. For this reason, understanding these reactions from a kinetics and thermodynamic perspective is critical to ensuring yield, quality and safety of the process.

Catalytic Reactions

Catalysts create an alternative path to increase the speed and outcome of a reaction, so a thorough understanding of the reaction kinetics is important. Not only does that provide information about the rate of the reaction, but also provides insight into the mechanism of the reaction. There are two types of catalytic reactions: heterogeneous and homogeneous. Heterogeneous is when the catalyst and reactant exist in two different phases. Homogeneous is when the catalyst and the reactant are in the same phase..

synthesis reactions

One of the four major classes of chemical reactions, synthesis reactions are represented by important examples in organic synthesis, catalyzed chemistry, polymerizations and inorganic/organometallic chemistry. In the simplest case, a synthesis reaction occurs when two molecules combine to form a third, more complex product molecule. Often, synthesis reactions are more complex and require a thorough understanding of the kinetics and mechanisms of the underlying chemistry, as well as carefully controlled reaction conditions.

Design of Experiments (DoE)

Design of Experiments (DoE) requires experiments to be conducted under well-controlled and reproducible conditions in chemical process optimization. Chemical synthesis reactors are designed to perform DoE investigations ensuring high quality data.

Fourier Transform Infrared (FTIR) Spectroscopy For Real-Time Monitoring Of Chemical Reactions

Reaction Mechanism Pathway

Reaction mechanisms describe the successive steps at the molecular level that take place in a chemical reaction. Reaction mechanisms cannot be proven, but rather postulated based on empirical experimentation and deduction. In situ FTIR spectroscopy provides information to support reaction mechanisms hypotheses.

Organometallic Synthesis

Organometallic Synthesis, or Organometallic Chemistry, refers to the process of creating organometallic compounds, and is among the most researched areas in chemistry. Organometallic compounds are frequently used in fine chemical syntheses and to catalyze reactions. In situ Infrared and Raman spectroscopy are among the most powerful analytical methods for the study of organometallic compounds and syntheses.

Oligonucleotide Synthesis

Oligonucleotide synthesis is the chemical process by which nucleotides are specifically linked to form a product of desired sequenced.

What is Alkylation?

Alkylation is the process by when an alkyl group is added to a substrate molecule. Alkylation is a widely used technique in organic chemistry.

Epoxides

This page outlines what epoxides are, how they are synthesized and technology to track reaction progression, including kinetics and key mechanisms.

The Suzuki and related cross-coupling reactions use transition metal catalysts, such as palladium complexes, to form C-C bonds between alkyl and aryl halides with various organic compounds. These catalyzed reactions are widely used methods to efficiently increase molecular complexity in pharmaceutical, polymer, and natural product syntheses. PAT technology is used to investigate cross-coupled reactions with regard to kinetics, mechanisms, thermodynamics, and the effect of reaction variables on performance and safety.

Lithiation Organolithium Reactions

Lithiation and organolithium reactions are key in the development of complex pharmaceutical compounds; organolithium compounds also act as initiators in certain polymerization reactions.

Publicaties

Publications on Synthetic Organic Chemistry

White Papers

Technieken voor het synthetiseren van doorbraakmoleculen
Dankzij ontwikkelingen op het gebied van organische scheikunde kunnen onderzoekers de R&D van moleculen uitbreiden en de procesvoorwaarden optimaliser...
Chemical Synthesis Beyond the Round Bottom Flask
Learn how to improve your organic synthesis!This white paper discusses new methodologies for organic synthesis including how to: Cool and heat without...
Metal Catalyzed Transformations met gebruik van In Situ spectroscopie
In situ Fourier Transform Infrared (FTIR) spectroscopie biedt real-time informatie om de belangrijkste reacties te bepalen. ReactIR is ontworpen om re...
Monitor chemische reacties in minder tijd
Hoe men meer kan doen in minder tijd is een constant onderwerp in chemische ontwikkelingslaboratoria, omdat onderzoekers snel en rendabel chemische pr...
Process FTIR voor de veilige werking van een natriumboorhydride-reductie.
John O'Reilly van Roche in Ierland bespreekt het duurzame Process Analytical Technology (PAT)-systeem met Process FTIR voor de veilige werking van een...
over real time reaction monitoring: tandem hydroformylering/hydrogenering
Real-time in situ mid-FTIR reaction monitoring leidt tot een beter inzicht in katalysatoractiviteiten en robuustheid. Onderzoekers van de Universiteit...
Grignard reacties opschalen – 4 stappen voor veilige opschaling
Exotherme chemische reacties houden risico's in, zeker bij opschaling. Gepubliceerde onderzoeken van top chemie en farmaceutische bedrijven laten zien...
Snelle analyse van experimenten voor optimalisatie van continue reacties
De white paper ‘Snelle analyse van experimenten voor optimalisatie van continue reacties’ bespreekt hoe chemische reacties geoptimaliseerd kunnen word...
3 Reaction Monitoring Case Studies
In this whitepaper, three case studies carried out at GlaxoSmithKline (GSK) demonstrate how probe-based and real-time FTIR instrumentation helped to c...
Het moderne syntheselab
Deze white paper bespreekt een nieuwe toolbox, speciaal ontworpen voor chemici, die meer experimentele opties biedt, saaie taken automatiseert en hoog...
Chemical Reaction Profiling: A Review
This white paper, In Situ Reaction Profiling: A Literature Review, reviews 20 examples from academic institutions that utilize in situ FTIR Spectrosco...
Reaction Insight from Every Experiment
This paper presents five examples taken from recent journal articles in which HPLC alone was not sufficient to provide the insight scientists needed....

Webinars

Hydrogenation Under High Pressure
This presentation discusses the implementation of Fourier Transform Infrared (FTIR) reaction monitoring technology to provide knowledge and understand...
Merck Chemical Process Development
Shane Grosser bespreekt hoe Merck's Process Development Intensification Laboratory nieuwe functies en methodes ontwikkelt om de snelheid van de chemis...
Reaction Kinetics Progress Analysis Ryan Baxter
Deze webinar bestudeert een grafische analyse-aanpak om ongebruikelijke kinetiek in C-H activeringen te rationaliseren. De 'Reaction Progress Kinetic...
Hydrogenation Under High Pressure
This presentation discusses the implementation of Fourier Transform Infrared (FTIR) reaction monitoring technology to provide knowledge and understand...
DoE to Peptide Synthesis
Learn how Design of Experiments (DoE) is applied to chemical synthesis at Lonza Peptide.
New Radical Reactions Enabled by In Situ Reaction Monitoring
Presented by Professor Ryan Baxter of the University of California-Merced, this on-demand webinar discusses research that involved new radical reactio...
Process Development and Kinetic Understanding
Presented by Eric Moschetta, this on-demand webinar describes how AbbVie built a robust kinetic model to understand a late stage API process
Alkylation Reaction Development
Kevin Stone discusses how Merck Chemical Engineering Research & Development (CERD) leverages process fingerprinting tools in the development of an Alk...

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Synthetic Organic Chemistry Tools

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