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An online water bioburden analyzer is a rapid microbial method for measuring microbial contamination in pharmaceutical grade waters. It offers a real-time microbial monitoring solution, providing continuous results every two seconds for better control of your water system. The 7000RMS rapid bioburden analyzer uses advanced, laser-induced fluorescence and Mie scattering technology to provide immediate detection and quantification of microorganisms.
The real-time microbial detection analyzer 7000RMS combines two well-established measurement technologies, laser-induced fluorescence and Mie scattering. The microbial analyzer counts individual microorganisms present in pharmaceutical water. Without collecting a sample or waiting days for plate count results, the 7000RMS delivers instant real-time monitoring of bioburden contamination.
Providing continuous results every two seconds, this real-time microbial analyzer requires no sample preparation or incubation period, eliminating delays in product release.
The 7000RMS microbial detection analyzer eliminates the variability and time-consuming nature of traditional plate counting with rapid microbial monitoring to ensure water quality.
Combining two well-established measurement technologies, the bioburden analyzer uses laser-induced fluorescence and Mie scattering to count microorganisms in pharmaceutical grade water systems.
With the ability to monitor water system trends prior to an out-of-specification event, the real-time microbial analyzer helps to identify the root cause of contamination events.
Rapid microbial monitoring with the 7000RMS online water bioburden analyzer gives you full visibility of changes in contamination levels to reduce risk and ensure water quality for release.
The 7000RMS bioburden analyzer provides microbial detection of organisms down to 0.3 micron, and the technology does not rely on the formation of colonies like traditional plate counting methods.
Use continuous trending data with the rapid microbial method to establish a baseline and monitor any shifts before and after sanitization to determine a cycle's frequency and effectiveness.
METTLER TOLEDO Thornton’s 7000RMS™ is an on-line analyzer for real-time measurement of microbial contamination (bioburden) in pharmaceutical water. Laser-based technology enables immediate detection and quantification of microorganisms directly from the water sample, overcoming limitations of time-consuming growth-based methods. Read more
The METTLER TOLEDO Thornton 7000RMS (Real-time Microbial Detection System) is suitable for monitoring microbial contamination in high purity water systems such as Purified Water (PW) and Water For Injection (WFI) systems by the synchronized optical detection of particle scattering and fluorescence from bacteria metabolites. Read more
The 7000RMS™ combines two well-established measurement techniques, laser-induced fluorescence and Mie scattering, to count individual microorganisms present in pharmaceutical grade waters. The 7000RMS delivers continuous, 24/7 monitoring of bioburden contamination without collecting a sample or waiting days for plate count results. Read more
Expert system services provide peace of mind and ensure that your analyzer is performing optimally to deliver process control. Our skilled technicians provide thorough inspection, cleaning and operational testing to ensure there are no out-of-specification performance issues at each recommended maintenance and calibration interval. Read more
Culture-based lab measurements of microbes can create challenges. Microbial monitoring in Purified Water, Ultrapure Water and Water for Injection has almost exclusively depended on time-consuming and error-prone culture-based lab measurements. Read more
We support and service your measurement equipment through its entire life-cycle, from installation to preventive maintenance and calibration to equipment repair.
There are numerous ways to measure microbial contamination of water, and USP recommends specific ways of doing so for pharmaceutical waters. Traditionally plate count methods are widely used for releasing water; however, they are prone to error and can take 5-7 days for results. Plate counting also requires the formation of a colony of bacteria on a plate and hence the measurement unit is called 'colony forming unit" or CFU, which is an estimation of the total number of bacteria present in the sample plate. Another way of measuring microbial contamination in water is through laser-induced fluorescence, with a microbial detection analyzer. These analyzers uses laser induced florescent technology to measure the total number of cells that are present in the sample volume of water. Systems that uses this type of technology allow for at-line, real-time monitoring of microbial contamination in pharmaceutical waters by identifying cells present in the sample water immeditely and is reported as auto fluorescent units (AFUs).
Auto fluorescent units or AFU are individual microorganisms and are reported in cells/mL. The 7000RMS illuminates the sample with a laser, resulting in Mie scattering form any particle present in the sample and also florescent scattering from metabolites (NADH and riboflavin) which are present in all bacteria. With the use of advanced algorithms and sample processing, the 7000RMS analyzes and reports the number of cells/bacteria present in the water sample as AFU.
UPW and WFI. This bioburden analyzer, when used in parallel with plate counting, offers a rapid microbial method (RMM) solution for better microbial control of your water system, reducing the risk of releasing contaminated water and improving process control. The bioburden analyzer uses laser-induced fluorescence and Mie scattering to provide continuous monitoring with results every two seconds, which can give you better process transparency and thus help you to reduce cost significantly.
The 7000RMS online water bioburden analyzer has a variety of applications. The bioburden analyzer is used for measurements of microbial contamination in Pharmaceutical Grade Waters including Pure Water (PW), Ultrapure Water (UPW), and Water for Injection (WFI) in any industry where they are used.
The 7000RMS bioburden analyzer provides microbial detection of organisms down to 0.3 micron. The technology does not rely on the formation of colonies like traditional plate counting methods.
When used in parallel with plate counting, this online water bioburden analyzer offers a rapid microbial method (RMM) solution designed to improve your process control, by providing you better understanding of your entire water loop on a regular basis giving you better process transparency and helping you to act quickly when an excursion event occurs. The analysis time is continuous, and the anlayzer provides results every two seconds, requiring no sample preparation or incubation period.
