FBRM 기술 을 갖춘 ParticleTrack G400는 견고한 프로브 기반 기기로 실험실 반응기에 직접 삽입되어 전체 공정 농도에서 입자와 액적 크기 및 개수 변화를 실시간으로 추적합니다. 실험 조건이 다양하기 때문에 입자, 입자 구조 및 액적은 지속적으로 모니터링되며 필요한 속성을 지닌 일관된 입자를 제공하는데 필요한 증거를 과학자에게 제공합니다.
입자 크기 및 개수는 결정화, 유화 및 응집을 포함하는 다중 위상 공정 내 성능에 직접적인 영향을 미칩니다. 과학자들은 입자 크기 및 개수를 실시간으로 모니터링하여 증거 기반 분석법을 통한 확신을 가지고 공정을 이해하고 최적화하며 확대할 수 있습니다.
오프라인 분석을 위해 샘플링되고 준비하는 과정에서 입자는 변할 수 있습니다. 입자가 공정에 자연스럽게 존재하는 상태에서 연구원들은 입자 크기 및 개수 변화를 추적함으로써 극한의 온도 및 압력에서도 시간 지연 없이 공정을 안전하게 보장합니다.
실험 조건이 변함에 따라 입자를 지속적으로 모니터링함으로써 입자 크기 및 개수에 대한 공정 파라미터의 영향을 파악할 수 있습니다. 최적화된 속성을 가진 입자를 일관성 있게 제공하는 공정을 설계하는데 이런 고유 정보를 사용할 수 있습니다.
실험실 내 ParticleTrack G400용 일반 어플리케이션에 다음이 포함됩니다.
ParticleTrack G400의 핵심 기능:
ParticleTrack G400는 이전 METTLER TOLEDO Lasentec FBRM 기술(D600/D600Ex)에 상당한 개선을 나타냅니다(S400 및 D600).
Insert ParticleTrack probes directly into process streams to monitor particle size and count continuously over time without having to take a sample.
What is Focused Beam Reflectance Measurement (FBRM) technology?
측정 범위 | 0.5 – 2000μm |
Temperature Range (Base/Field Unit) | 5 to 35°C |
Base Unit Description | 실험실 기본 장치 |
Base Unit Dimension (길x높x폭) | 492 mm x 89 mm x 237 mm |
Certifications | CE Approved, Class 1 Laser, NRTL Certified, CB Scheme Certified |
Power Requirements | |
For Use In | Laboratory: EasyMax/OptiMax |
소프트웨어 | iC FBRM |
Scanning System | Electric Scanner |
Scan Speeds | 2m/s (19mm at 1.2m/s) |
Chord Selection Method (CSM) | Primary (fines) AND Macro (coarse) |
Probe Diameter | 19mm 9.5mm 14/9.5mm |
Probe Wetted Length | 400mm (for 19mm probe) 206mm (for 14/9.5mm probe) 91mm (for 9.5mm probe) |
Probe Wetted Alloy | C22 |
창 | 사파이어 |
Standard Window Seals | Kalrez® (standard 19mm) TM (standard 14/9.5) |
Probe/Window Options | TM Window (option for 19mm) |
Pressure Rating (Probe) | up to 100barg (custom) 3barg (standard) |
Temperature Rating (Probe) | +10 to 90°C (standard) -10 to 90°C (Kalrez and purge) -80 to 90°C (TM and purge) |
Conduit Length | 3m [9.8ft] |
Air Requirements | Max. purge manifold outlet pressure: 0.8barg [12psig] Max. inlet pressure to purge manifold: 8.6barg [125 psig] Low flow purge: (use to avoid condensation) Max. Flow: 5NL/min [0.2SCFM] |
ParticleTrack Model | ParticleTrack G400 |
FBRM 기술을 갖춘 ParticleTrack G400는 폭발성 위치에 대하여 등급 평가되지 않았습니다.
ParticleTrack G400 represents a significant improvement over previous METTLER TOLEDO Lasentec FBRM technologies (S400 and D600).
Stuck Particle Correction Improves Consistent and Reliable Measurement - ParticleTrack can distinguish between particles stuck on the probe window and those moving in the process. These stuck particles can be removed from the data ensuring a consistent and reliable measurement for more experiments.
Improved Measurement Accuracy and Resolution - ParticleTrack uses state-of-the art digital signal processing methods to measure particle size with increased accuracy and resolution. These changes mean the measurement matches particle measurements such as laser diffraction and imaging more closely.
Wider Dynamic Range To Detect Critical Process Events - ParticleTrack measures changes in particle count to accurately eliminate concentration-related artifacts from the data and ensure improved sensitivity to changes in the particle system at higher concentrations. This allows critical process events to be detected that may previously have gone unobserved.
Interchangeable Probes Decrease Costs and Increase Range of Scales - Lab-based ParticleTrack instruments are now available with different sized probes that can be easily changed by the user. This improves serviceability and increases the range of scales where the same instrument may be used at an overall lower cost.
Two Measurements Acquired Simultaneously To Eliminate Need for Prior System Information or Trial Experimentation - ParticleTrack now collects two datasets simultaneously that are optimized for different types of particle systems. This eliminates the need for any a prior system information or trial experimentation to determine the optimal measurement method.
Improved Instrument to Instrument Repeatability - ParticleTrack technology was developed to ensure different lab and production instruments now measure much more closely, allowing changes in scale of measurement to be decoupled from differences in the probe used to measure them.
Voice of User
Senaputra, A., Jones, F., Fawell, P. D. and Smith, P. G. (2014), Focused beam reflectance measurement for monitoring the extent and efficiency of flocculation in mineral systems. AIChE J., 60: 251–265. doi: 10.1002/aic.14256.
"The [ParticleTracK]G400 also captures bimodal character in unweighted chord distributions, producing distinct peaks for aggregates and fines after suboptimal flocculation; such peaks are rarely well resolved in older FBRM".
"…the chord length measurement principle applied with the G400 probe leads to an enhanced sensitivity to species at the lower end of the measurement range relative to previous generation FBRM…"
"The mean square-weighted chord lengths reported from older generation FBRM for flocculated minerals are typically under 400 mm, and yet the naked eye can see much larger aggregates being formed in thickener feedwells. The G400 probe consistently measures larger chord lengths, and this is seen as a significant advantage"
George Zhou, Aaron J Moment, James F. Cuff, Wes A. Schafer,Charles Orella, Eric Sirota, Xiaoyi Gong, and Christopher J. Welch, Process Development and Control with Recent New FBRM, PVM, and IR. Org. Process Res. Dev., Just Accepted Manuscript, Publication Date (Web): 10 Jun 2014.
"Process analytical technologies (PATs) have played an important role in process development and optimization throughout the pharmaceutical industry. Recent new PATs, including in-process video microscopy (PVM), a new generation of focused-beam reflectance measurement (FBRM), miniature process IR spectroscopy, and a flow IR sensor, have been evaluated, demonstrated, and utilized in the process development of many drug substances. First, PVM has filled a technical gap by providing the capability to study morphology for particle engineering by visualizing particles in real time without compromising the integrity of sample. Second, the new FBRM G series has closed gaps associated with the old S series with respect to probe fouling, bearing reliability, data analysis, and software integration. Third, a miniaturized process IR analyzer has brought forth the benefits of increased robustness, enhanced performance, improved usability, and ease of use, especially at scale-up".