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PAT for Downstream Bioprocess Optimization |
Featuring presenters from Sanofi, Bristol-Myers Squibb, and GlaxoSmithKline, this free online event on February 26, 2020 is for scientists and engineers who are interested improving process performance by identifying, understanding and optimizing critical process parameters involved with downstream processing (DSP) of Drug Substances (DS), vaccines, excipients and/or bio conjugates.
Presentations include:
Presentations include:
- Low pH Virus Inactivation for Monoclonal Antibodies
Hiren D. Ardeshna - GlaxoSmithKline - Aluminum Phosphate Vaccine Adjuvant: Composition and Size Analysis Using Offline and Inline Tools
Marina Kirkitadze - Sanofi - Real-Time Monitoring of Downstream Biologics Operations
Greg Lane - Bristol-Myers Squibb
Each presentation will be followed by a live Q&A session with the presenter.
Jeremy Reddish - METTLER TOLEDO
2 Hours
Wed Feb 26 2020 15:00 +0100 [ English ]
Key Topics
- Identifying factors that could contribute to bottlenecks and impurity formation during bioprocess development
- Understanding how process conditions impact protein concentration and product yield
- Overcoming the challenges associated with offline analytical techniques, including inaccuracy and time delays
- Monitoring unit operations such as purification, chromatography, buffer exchange, up-concentration and formulation
Who Should Attend?
- Analytical Chemists or Engineers who Support Bioprocesses
- Process Development Scientists
- CMC Engineers
- Bioprocessing Engineers
- Downstream Development Scientists
- Director of Process Analytical Technology
- Conjugation Scientists
- VP/Director of Biologic Development
- VP/Director of Bioprocessing
- VP/Director of Process Development
- VP/Director of Biomanufacturing
- VP/Director of Bioproduction
- VP/Director of Biologics
- Chief Scientific Officers
Cost
There is no cost to attend but registration is required and space is limited.
Enhance Understanding with FTIR & Raman
Gain in-depth information about reaction kinetics, mechanisms, and pathways. Support scale-up of high-yield bioprocesses. ReactIR and ReactRaman spectrometers provide in situ, real-time monitoring of Biochemical reactions for batch and continuous processes.
- Develop real-time trending profiles for key reaction species: reactants, intermediates, products, and byproducts
- Obtain data-rich information for traditional kinetic analysis or Reaction Progress Kinetics Analysis (RPKA) methods
- Information obtained directly from reaction vessel, limiting risk of contamination of high value product by sample removal for traditional offline techniques.
- Investigate key stages of a reaction or process, such as reaction start, induction period, accumulation, conversion, and endpoint. Detect reaction stalling or upsets
- Rapidly determine the effect of variables on reactions to develop high-yield, robust bioprocesses
- Investigate the broadest range of chemical reactions with ReactIR and ReactRaman. Choose the best technique to obtain the most informative reaction variables and obtain biochemical specific information.