Particle Size Analyzers | FBRM and PVM Instruments

Particle Size Analyzers

Real Time Particle Size Analyzers For Laboratory and Process Environments

A particle size analyzer is an analytical instrument that measures, visualizes, and reports a particle size distribution for a given particle or droplet population. Particle size analyzers play an important role during process development and quality control of particle systems in order to develop efficient processes and achieve high final product quality.

Traditionally, sampling and offline particle size analyzers (laser diffraction, dynamic light scattering, sedimentation, or sieve rest analysis) were used for product quality control. However, common sampling challenges, increasing pressure to expedite process development, and a higher demand for "right first time" processes required the development of in situ particle size analyzer. The ability to measure particles as they naturally exist in a process has dramatically improved the ability to understand, optimize and control particle and droplet systems.

METTLER TOLEDO offers two different types of particles size analyzers. EasyViewer is an in situ video microscope that uses advanced image analysis to determine particles size. ParticleTrack is an in situ particle size analyzer that uses Focus Beam Reflectance Measurement (FBRM) to determine particle size.

Probe-based imaging tool that captures high-resolution images of crystals, particles, and droplets as they exist in process.
New Experimental Insights
Study crystallization, precipitation, suspensions, and emulsions at previously unobtainable levels of detail and reveal new insights that will power process development decision making.
Powerful Analytics with iC Vision
Monitor process changes using simple analytics, or quantify particle size and shape with customized algorithms.
Breakthrough Usability
With a slim, lightweight probe and plug-and-play connection, EasyViewer makes setup and data capture effortless. Smart focus and lighting controls alleviate the burden of manual interventions.
Confident Deployment
EasyViewer is built for frequent use and provides exceptional information - after as little as 15 minutes training.
EasyViewer
Probe-based instrument inserted directly into a process to study how particle size and count change over time with Focused Beam Reflectance Measurement (FBRM) technology.
Measure Particle Size and Count
By monitoring particle size and count in real time, scientists can understand, optimize and scale-up processes confidently using evidence-based methods.
Understand Without Sampling
By tracking changes to size and count, as particles naturally exist in process, scientists obtain process understanding safely and with no time delay - even at extreme temperatures and pressure.
Develop Processes Confidently
By tracking particle size and count continuously as experimental conditions are varied, it is possible to optimize processes and obtain fit for purpose particles on a consistent basis.
Deploy in the Lab and the Plant
By monitoring manufacturing processes, upsets can be identified quickly and improvements can be made using evidence collected at full production scale.
METTLER TOLEDO Lasentec FBRM
EasyViewer

Probe-based imaging tool that captures high-resolution images of crystals, particles, and droplets as they exist in process.

METTLER TOLEDO Lasentec FBRM

Probe-based instrument inserted directly into a process to study how particle size and count change over time with Focused Beam Reflectance Measurement (FBRM) technology.


Common particle size analyzer applications include:

Since acquiring Lasentec in 2001, METTLER TOLEDO has continued to advance the development of FBRM and PVM particle size analyzers. With thousands of in situ particle size analyzers installed worldwide from the R&D laboratory to the manufacturing plant, our probe-based technologies are acknowledged as the gold standard for particle size distribution analysis.  Our technology, including crystallization equipment, measures and visualizes the rate and degrees of change in particle and droplet systems as they naturally exist in process.

Particle Size Analyzer Frequently Asked Questions (FAQs)
What Does Particle Size Mean?
Every particle has a specific shape and different three-dimensional elongation. Particle size is an effective way to describe and characterize the dimensional properties (length, width, and height) of a particle. Although particles are usually of three-dimensional nature, a one-dimensional size function (for example, chord length, particle length or spherical equivalent diameter) is frequently used in practice.

Why is Particle Size Analysis Important?
Different particles can have very different physical properties and a certain particle size and shape will be optimal for a specific purpose.

  • Catalyst – Maximum Surface Area
  • Medicines – Highest Bio-Availability
  • Industrial Processing – Good Flowability

Particle size analysis is important for process optimization and quality control to ensure and document optimal particle properties. The wrong particle size, in the worst case, can mean that a particle product will not be fit-for-purpose and a downstream process might experience an unplanned shutdown.

What is Particle Size Measured In?
Particle size is measured in a length dimension like nm, µm, or mm. Depending on the industry and particles, a different size range can be applicable.

How Do You Measure Particle Size?
Macroscopic particles can, for example, be measured with a ruler or caliper. Microscopic crystals usually need more sophisticated analytical devices due to the reduced particle size. Typical particle size measurement techniques are image analysis, laser back-scattering, laser diffraction or sieve fraction analysis.

What is the Average Particle Size?
For particle populations of many different particle sizes (small to large) it is possible to calculate the arithmetic mean, median or mode as an integral function over all particles. The average particle size provides one averaged number that characterizes a larger particle population.

How Does a Particle Size Analyzer Work?
A particle size analyzer operates according to a specific method of measurement (for example, image analysis, laser back-scattering, or laser diffraction) with individual and method specific boundary conditions. There are a variety of particle size analyzers available. All particle size analyzers provide different values for the same particle, depending on their specific method of measurement.

Particle Size Analyzers in Recent Industry-Related Publications:
The selection of journal articles below utilize particle size analyzers to address measuring solubility and metastable zone, crystallization design, seeding crystallization processes, optimizing crystal shape, monitoring supersaturation, polymoprphic crystallization, phase separation (oiling out), managing impurities, crystallization scale-up, and continuous crystallization.

  • Seed Recipe Design for Batch Cooling Crystallization with Application to L-Glutamic Acid, Zhang et al., Ind. Eng. Chem. Res. 2019, 58, 8, 3175–3187
  • Effect of a polymer binder on the extraction and crystallization- based recovery of HMX from polymer-bonded explosives, Kim et al., Journal of Industrial and Engineering Chemistry, Volume 79, 25 November 2019, Pages 124-130
  • Diastereomeric Salt Crystallization of Chiral Molecules via Sequential Coupled-Batch Operation, Simon et al., AIChE Journal, Volume 65, Issue 8
  • On-line observation of the crystal growth in the case of the non- typical spherical crystallization methods of ambroxol hydrochloride, Gyulai et al., Powder Technology, Volume 336, August 2018, Pages 144-149
  • Characterization of a Multistage Continuous MSMPR Crystallization Process assisted by Image Analysis of Elongated Crystals, Capellades et al., Cryst. Growth Des. 2018, 18, 11, 6455–6469
  • Development and Scale-Up of a Crystallization Process To Improve an API’s Physiochemical and Bulk Powder Properties, Durak et al., Org. Process Res. Dev. 2018, 22, 3, 296–305
  • A continuous multi-stage mixed-suspension mixed-product-removal crystallization system with fines dissolution, Acevedo et al., Chemical Engineering Research and Design, Volume 135, July 2018, Pages 112-120

Services

Service for Particle Size Analyzer

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We support and service your measurement equipment through its entire life-cycle, from installation to preventive maintenance and calibration to equipment repair.

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Support

Support Documentation for Particle Size Analyzers

G400 Hardware Support

Positioning a ParticleTrack or ParticleView Probe
ParticleTrack probes use Focused Beam Reflectance Measurement (FBRM) technology to track the rate and degree of change to particles and particle struc...
Changing ParticleTrack G400 Interchangeable Probe Tips
This Quick Reference shows you how to quickly replace a ParticleTrack with FBRM G400 interchangeable probe tip and set the software to recognize the n...
Using the Purge Controller for ParticleTrack G400 or ParticleView V19
The Purge Controller is an optional accessory that can be purchased for use with ParticleTrack G400 and ParticleView V19. Purging is required where...
ParticleTrack G600 Hardware Manual
This manual covers safety and quality information relating to the METTLER TOLEDO ParticleTrack G600 with FBRM (Focused Beam Reflectance Measurement) t...
ParticleTrack & ParticleView Onsite Training
Training and familiarization with ParticleTrack and ParticleView will ensure that all users can walk up to instruments and immediately bring value to...

V19 Hardware Support

Positioning a ParticleTrack or ParticleView Probe
ParticleTrack probes use Focused Beam Reflectance Measurement (FBRM) technology to track the rate and degree of change to particles and particle struc...
Using the Purge Controller for ParticleTrack G400 or ParticleView V19
The Purge Controller is an optional accessory that can be purchased for use with ParticleTrack G400 and ParticleView V19. Purging is required where...
ParticleView V19 Hardware Manual
This manual covers specific safety and quality information relating to the ParticleView V19 with PVM (Particle Vision Measurement) technology. The P...
ParticleView V19 Safety Manual
This safety manual supplements the ParticleView V19 with PVM Technology Hardware Manual.
ParticleTrack & ParticleView Onsite Training
Training and familiarization with ParticleTrack and ParticleView will ensure that all users can walk up to instruments and immediately bring value to...

G600 Hardware Support

Positioning a ParticleTrack or ParticleView Probe
ParticleTrack probes use Focused Beam Reflectance Measurement (FBRM) technology to track the rate and degree of change to particles and particle struc...
ParticleTrack G600 Hardware Manual
This manual covers safety and quality information relating to the METTLER TOLEDO ParticleTrack G600 with FBRM (Focused Beam Reflectance Measurement) t...
ParticleTrack G600Ex Hardware Manual
This manual covers safety and quality information relating to the ParticleTrack G600Ex with FBRM (Focused Beam Reflectance Measurement) technology.
ParticleTrack & ParticleView Onsite Training
Training and familiarization with ParticleTrack and ParticleView will ensure that all users can walk up to instruments and immediately bring value to...

Software Support

iC PVM Software Quick Start Guide
This guide introduces a new user to the iC PVM software graphical user interface (GUI) and describes several choices for getting started. Create and r...
iC PVM Software User Install Guide
iC PVM installation is wizard-guided. This guide includes detailed installation steps along with implementation information for the iC PVM administra...
ParticleTrack & ParticleView Onsite Training
Training and familiarization with ParticleTrack and ParticleView will ensure that all users can walk up to instruments and immediately bring value to...
iC FBRM Software
iC FBRM delivers key information to help users develop a strong understanding of their particle system dynamics, optimize experimental design, speed d...
iC PVM particle characterization software
Acquire and share process knowledge by viewing particles in real time to understand particle size, shape and concentration with iC PVM Software.
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