Characterization of pharmaceuticals using thermal analysis

Thermal Analysis of Pharmaceuticals Guide


Thermal Analysis is Used in Practically All Analytical Laboratories in the Pharmaceutical Industry For the Characterization of Drug Substances, Excipients, and Packaging Materials

Characterization of pharmaceuticals
Characterization of pharmaceuticals

METTLER TOLEDO's "Characterization of Pharmaceuticals" guide was designed to support thermal analysis (TA) users with real examples of the most relevant applications pertinent to the pharmaceutical industry. Specifically, the guide includes examples for how thermal analysis techniques – in particular DSC and TGA – can be used to investigate polymorphism and pseudopolymorphism, stability, interactions, purity and packaging materials.

Table of Contents

  1. What thermal analysis can do for pharmaceuticals
  2. Applications and their thermal analysis techniques
  3. Examples:
    • Polymorphism – Sulfapyridine
    • Stability – Acetylsalicylic acid
    • Characterization/Identification – Vanillin
    • Characterization/Identification – Polyethylene glycol PEG
    • Purity – Phenacetin and PABA
  4. Measurement errors and measurement uncertainty
  5. Method development
  6. Instrument calibration and adjustment
  7. Introduction to thermal analysis techniques
  8. Excellent crucibles, accessories and reference materials
  9. More information
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