Solid phase synthesis is a technique where molecules are temporarily bound to an insoluble support in order to streamline the synthesis process. Advantages include easy removal of excess reactants and by products via washing and filtration. Applications include synthesis of peptides and pharmaceuticals. New synthetic methods for solid-phase synthesis are routinely developed. Parallel solid phase synthesis is a valuable alternative to traditional synthesis.
The MiniBlock has fritted reaction vessels and combined with its patented built-in valve makes solid phase synthesis easy and elegant: tedious resin washing steps can be performed by simply opening/closing the valve in order to remove and add solvents. Vortex mixing ensures thorough agitation of resins.
The reaction required precise heating at 80C, followed by a cleavage step, which included diversity elements in the cleavage cocktail. The same authors reported a series of novel amidation reactions requiring completely inert conditions, resulting in yields of over 95%.
Source: S. Brase, S. Dahmen, J. Heuts, Tetrahedron Left. 1999, 40, 6201-6203