The particle size distribution is one of the most critical parameters in drug product quality. Real time understanding and control of particles ensures Quality by Design (QbD) in solid and liquid dosage formulation. FBRM® and PVM® Process Analytical Technologies (PAT) provide in-process real time measurements of particle dimension, particle shape, and particle count. FBRM® and PVM® are used to promote faster formulation development, improve process confidence, and control batch-to-batch consistency.
- Dissolution Testing - FBRM® tracks tablet, capsule, and granule disintegration and dissolution mechanisms in real time to uncover the root cause of dissolution performance inconsistencies
- Liquid Suspensions - Ensure particle stability and homogeneity by tracking the particle distribution in real time
After purchasing Lasentec® in 2001, METTLER TOLEDO has become the world leader for in-line particle/droplet size, shape, and count characterization.
التطبيقات
Automated Solutions and In-Situ PAT to Support LNP Formulation
Learn how automated lab reactors and in-situ PAT enabled rapid process scale-up of PEG-lipid nanoparticle (LNP) formulation for mRNA vaccines during the COVID-19 pandemic.
المنتجات ذات الصلة
Particle Size Analyzers
Understand, optimize, and control particles and droplets in real time with in-situ particle size analyzers.