Frederic Buono discusses how Boehringer Ingelheim uses continuous flow technology to break barriers in manufacturing innovation.
New Tools For Continuous Flow Chemistry
Andrea Adamo of Massachusetts Institute of Technology (MIT) and Zaiput Flow Technologies discusses new tools for continuous flow chemistry advancement. Join over 500 researchers who have already viewed this presentation.
Pharmaceutical manufacturing is complex and involves operations in different locations and complex supply chains. Delays and long production times are a common issue. Dr. Adamo discusses new continuous flow chemistry tools developed in the context of the “Pharmacy On-Demand” project at Massachusetts Institute of Technology (MIT). The Pharmacy On-Demand project focuses on the development of portable synthesis systems for the on-demand manufacturing of drugs.
The approach used for the Pharmacy On-Demand initiative included:
- Flow approach: robust, compact, repeatable, easy-to-automate, scalable
- Modular unit operation with flexibility for development, upgrade, use, reconfiguration
- Use of Process Analytical Technology (PAT) tools to enable faster development and continuous monitoring
Challenges faced by the Pharmacy On-Demand project included:
- Need for adequate, chemically compatible equipment
- Inline separation and purification
- Pressure coordination, stalling of pumps, clogging, etc.
- Average residence time generally less than 30 minutes (batch: hours/days/weeks)
- Crystallization and formulations
Dr. Adamo presents the type of continuous flow chemistry tools that were developed. The main elements of which are:
- Easy-to-maintain reactors
- Liquid-liquid separators for inline work-up
- Accurate and chemically stable back pressure regulators
This talk presents the process configuration that was developed for the synthesis of four different drugs and how all these process were incorporated in a single portable continuous flow chemistry system. Dr. Adamo covers some applications of multi-state extraction that stem out from the availability of new modular tools.
Presenter: Dr. Andrea Adamo
Dr. Andrea Adamo is an entrepreneur with experience in innovative engineering solutions, including developing Zaiput Core Technologies. He serves as the Innovation Advisor at Snapdragon Chemistry. Dr. Adamo holds a Master of Science in Engineering from the University of Palermo, Ph.D. in Fluid Mechanics from the University Federico, and a Master of Science from the Massachusetts Institute of Technology. He was awarded a Fulbright Scholarship. After completing his graduate studies, Dr. Adamo joined the laboratory of Professor Klavs Jensen in the MIT Department of Chemical Engineering. He worked in the Jensen Group as both a post-doctoral associate and research associate. In these positions, Dr. Adamo gained experience in the design and manufacturing of innovative microfluidic and millifluidic systems for biology and continuous flow chemistry applications.