Dalam industri kimia dan farmasi, sebagian proses dilaksanakan dalam mode batch atau semi-batch. Potensi bahaya dan risiko proses kimia dikaitkan dengan reaktifitas dan toksisitas bahan kimia yang terlibat dan desain proses itu sendiri. Sementara toksisitas reagen tidak dapat diubah, desain proses yang sesuai penting untuk mempertahankan kontrol atas reaksi sepanjang waktu. Karena tidak ada operasi batch maupun semi-batch yang tetap, dinamika proses menjadi salah satu faktor penting yang perlu diukur secara cermat. Oleh karena itu, usaha mewujudkan proses yang dipastikan aman adalah tujuan pengembangan proses.
Kajian Risiko Keselamatan Skala Kecil
Kajian risiko keselamatan selama alur kerja pengembangan proses di atas timbangan 50-100ml disajikan. Sebuah sintesis dua langkah dengan reaksi deprotonasi dan oksidasi ganda dilaksanakan. Reaksi ini terbukti menunjukkan risiko keselamatan termasuk terlambatnya permulaan reaksi diikuti akumulasi panas dan pelepasan panas seketika. Jika masalah ini terdeteksi sejak awal, langkah pengembangan dapat diambil untuk memodifikasi proses reaksi dan menambahkan kontrol sebelum penambahan.
Pemonitoran Suhu Panas Reaksi Versus Kalorimetri
Penyaringan aliran panas kalorimetridalam sebuah bejana reaksi 100ml menghasilkan informasi yang tidak ditemukan dalam pengukuran suhu saja. Data dari reaksi oksidasi eksotermik menunjukkan pengukuran suhu reaktor (Tr) bukan indikator akurat panas reaksi. Suhu reaktor minus suhu jaket (Tr-Tj) meremehkan pelepasan energi dan konsekuensi keselamatan yang diakibatkannya. Profil panas reaksi (Q) dari kalorimetri aliran panas melacak pelepasan panas kuantitatif dan menjadi indikasi terbaik potensi masalah bahkan sebelum penambahan 1 liter.
Panduan Kalorimetri Reaksi
Pelajari nilai mengimplementasikan kalorimetri reaksi dalam proses serta cara mengoptimalkan investigasi keselamatan proses.
Aplikasi
Risks of Explosions in Chemical Process and How to Avoid Hazards in the Plant
Scientists and engineers eliminate risks of explosions in a chemical plant with a comprehensive safety study. The safety study is applied to develop a process that eliminates uncontrolled heat or gas generation, flammable vapor release, or an over-pressurization of the reactor leading to rupture and loss of contents, which may be flammable. In order to avoid the risk of uncontrolled heat generation, reaction calorimetry determines the heat of reaction and the rate of heat release, so that a process can be designed that minimizes the risk of loss of control.
Develop a Safe Chemical Process
Essential measurements and calculations are necessary to model runaway scenarios and establish the ideal reaction procedure. Measuring, calculating, and understanding the parameters are essential to assess and avoid risk in a chemical process. This allows scientists to make predictions about the temperature profiles, maximum operating temperature, and dosing.
Assess the Risk of Chemical Processes
The heat of reaction, or reaction enthalpy, is an essential parameter to safely and successfully scale-up chemical processes. The heat of reaction is the energy that is released or absorbed when chemicals are transformed in a chemical reaction.
Scientists and engineers eliminate risks of explosions in a chemical plant with a comprehensive safety study. The safety study is applied to develop a process that eliminates uncontrolled heat or gas generation, flammable vapor release, or an over-pressurization of the reactor leading to rupture and loss of contents, which may be flammable. In order to avoid the risk of uncontrolled heat generation, reaction calorimetry determines the heat of reaction and the rate of heat release, so that a process can be designed that minimizes the risk of loss of control.
Essential measurements and calculations are necessary to model runaway scenarios and establish the ideal reaction procedure. Measuring, calculating, and understanding the parameters are essential to assess and avoid risk in a chemical process. This allows scientists to make predictions about the temperature profiles, maximum operating temperature, and dosing.
Publikasi
Publikasi Analisis Bahaya Termal
Guides
Kalorimetri Reaksi memberikan pemahaman akan proses kimia dan menjadi sumber informasi keselamatan dan naik skala. Kalorimeter reaksi menentukan bagai...
Webinar Atas Permintaan
As chemical reactions are scaled from lab to manufacturing, potential safety issues of non-scalable conditions need to be identified early in developm...
This webinar discusses how to perform safe scale-up of chemical processes and includes a close examination of thermal risks and hazards.
This presentation discusses polymerization process monitoring and how the value of real-time in situ Fourier Transform Infrared (FTIR) spectroscopy co...
Data gathered at various pH values will be discussed. The influence of pH will be presented on the purity and thermal stability of the explosive produ...
Produk Terkait
Teknologi Yang Digunakan dalam Analisis Keselamatan Proses Kimia dan Bahaya Termal
Reaction Calorimeters
Reaction calorimeters measure the amount of energy released or absorbed by a chemical or physical reaction in chemical and pharmaceutical development.
Webinar Sesuai Permintaan