Improving Water System Performance
This article discusses real time TOC monitoring in the water purification process and the importance of rapid, continuous and reliable TOC measurement and control for real time critical water release.
Water is the most widely used excipient in pharmaceutical and biotech manufacturing processes. It is used as an ingredient, reagent, solute, delivery device, cleaning material, and in some cases, the water is the end product such as Sterile Water for Injection. In pharmaceutical production, the accurate measurement of water quality is critical to the water purification process. This industry mandates the monitoring of Total Organic Carbon (TOC) as specified in the monographs of the United States Pharmacopoeia (USP) for Purified Water (PW) and Water for Injection (WFI), and in the European Pharmacopoeia (EP) monographs for these same waters as well as Highly Purified Water (HPW). In these monographs, the specific TOC testing requirements for these waters are referenced in USP 〈643〈 and in the EP 2.2.44 general test chapters.