Improving Water System Performance - METTLER TOLEDO
White Paper

Improving Water System Performance

White Paper
Improving Water System Performance
Improving Water System Performance

This article discusses real time TOC monitoring in the water purification process and the importance of rapid, continuous and reliable TOC measurement and control for real time critical water release.

Water is the most widely used excipient in pharmaceutical and biotech manufacturing processes. It is used as an ingredient, reagent, solute, delivery device, cleaning material, and in some cases, the water is the end product such as Sterile Water for Injection. In pharmaceutical production, the accurate measurement of water quality is critical to the water purification process. This industry mandates the monitoring of Total Organic Carbon (TOC) as specified in the monographs of the United States Pharmacopoeia (USP) for Purified Water (PW) and Water for Injection (WFI), and in the European Pharmacopoeia (EP) monographs for these same waters as well as Highly Purified Water (HPW). In these monographs, the specific TOC testing requirements for these waters are referenced in USP 〈643〈 and in the EP 2.2.44 general test chapters.


Thank you for visiting www.mt.com. We have tried to optimize your experience while on the site, but we noticed that you are using an older version of a web browser. We would like to let you know that some features on the site may not be available or may not work as nicely as they would on a newer browser version. If you would like to take full advantage of the site, please update your web browser to help improve your experience while browsing www.mt.com.