ParticleTrack with FBRM Technology | Particle Size and Count Analysis

Measure and Count Particles In-Situ and in Real Time

What is the difference between the ParticleTrack G400 and G600 models?

In short, the G400 and G600 models were designed with different process environments in mind. The ParticleTrack G400 is best suited for laboratory applications while the G600 model is best for pilot plant and plant operations. 

Unsure of which model is best for your application? Contact us today!

What is FBRM? How does it work?

what is FBRM

what is FBRM
what is FBRM

FBRM™ (Focused Beam Reflectance Measurement) is a measurement technique used for in-process particle measurement. The precise and sensitive chord length distributions (CLD) are highly responsive to changes in size, shape, or count. 

The probe is placed at an angle straight into process streams to allow particles to flow freely across the probe window where the measurement takes place. Through a system of optics, a laser beam is sent down the probe tube and narrowly focused on the sapphire window. The optics rotate at a constant rate (usually 2 m/s), which causes the beam spot to sweep through particles quickly as they pass by the window.

Individual particles or particle structures will backscatter the laser light to the detector when the concentrated beam travels through the particle system. These separate backscattered light pulses are identified, counted, and the distance across each particle is determined by multiplying the duration of each pulse by the scan speed.

The chord length, a crucial indicator of the particle's relationship to particle size, is used to determine this distance. Thousands of particles are typically counted and measured per second, enabling the real-time reporting of an accurate and very sensitive chord length distribution.

The chord length distribution charts the evolution of particle size and counts from the start to the finish of a procedure. It is possible to chart the evolution of statistics from each chord length distribution, such as counts in the fine and coarse size classes.

Crystallization Process Design

Crystallization Process Design

New Technologies for Crystallization Process Design

PAT for Emulsions

PAT For Emulsions

Utilizing Process Analytical Technology (PAT) to Optimize Emulsions

Crystallization Process pdf

Effective Crystallization Process Development

A Guide to Crystallization and Precipitation

crystal size distribution ppt

Strategies To Control Crystal Size Distribution

Advanced Techniques To Optimize Crystal Size Distribution During Process Development and Manufacturing

Improve Purification of Biological Systems

Improve Purification of Biological Systems

Inline Monitoring to Improve Purification of Biological Systems

Crystallization in Process Chemistry

Crystallization in Process Chemistry

Applying Simple PAT Tools

ParticleTrack in Journal Publications

  • McTague, H., & Rasmuson, K. C. (2021). Nucleation in the Theophylline/Glutaric Acid Cocrystal System. Crystal Growth & Design, 21(7), 3967–3980. doi.org/10.1021/acs.cgd.1c00296
  • Sirota, E., Kwok, T., Varsolona, R. J., Whittaker, A., Andreani, T., Quirie, S., Margelefsky, E., & Lamberto, D. J. (2021). Crystallization Process Development for the Final Step of the Biocatalytic Synthesis of Islatravir: Comprehensive Crystal Engineering for a Low-Dose Drug. Organic Process Research & Development, 25(2), 308–317. doi.org/10.1021/acs.oprd.0c00520
  • Smith, J. P., Obligacion, J. V., Dance, Z. E. X., Lomont, J. P., Ralbovsky, N. M., Bu, X., & Mann, B. F. (2021). Investigation of Lithium Acetyl Phosphate Synthesis Using Process Analytical Technology. Organic Process Research & Deve...
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  • McTague, H., & Rasmuson, K. C. (2021). Nucleation in the Theophylline/Glutaric Acid Cocrystal System. Crystal Growth & Design, 21(7), 3967–3980. doi.org/10.1021/acs.cgd.1c00296
  • Sirota, E., Kwok, T., Varsolona, R. J., Whittaker, A., Andreani, T., Quirie, S., Margelefsky, E., & Lamberto, D. J. (2021). Crystallization Process Development for the Final Step of the Biocatalytic Synthesis of Islatravir: Comprehensive Crystal Engineering for a Low-Dose Drug. Organic Process Research & Development, 25(2), 308–317. doi.org/10.1021/acs.oprd.0c00520
  • Smith, J. P., Obligacion, J. V., Dance, Z. E. X., Lomont, J. P., Ralbovsky, N. M., Bu, X., & Mann, B. F. (2021). Investigation of Lithium Acetyl Phosphate Synthesis Using Process Analytical Technology. Organic Process Research & Development, 25(6), 1402–1413. doi.org/10.1021/acs.oprd.1c00091
  • Kavanagh, O., Hogan, F., Murphy, C., Croker, D., & Walker, G. (2020). Formulating a Stable Mannitol Infusion while Maintaining Hyperosmolarity. Pharmaceutics, 12(2), 187. doi.org/10.3390/pharmaceutics12020187
  • Kutluay, S., Ceyhan, A. A., ŞAhin, M., & İZgi, M. S. (2020). Utilization of In Situ FBRM and PVM Probes to Analyze the Influences of Monopropylene Glycol and Oleic Acid as Novel Additives on the Properties of Boric Acid Crystals. Industrial & Engineering Chemistry Research, 59(19), 9198–9206. doi.org/10.1021/acs.iecr.0c00551
  • Tanaka, K., & Takiyama, H. (2019). Effect of Oiling-Out during Crystallization on Purification of an Intermediate Compound. Organic Process Research & Development, 23(9), 2001–2008. doi.org/10.1021/acs.oprd.9b00256
  • Yang, H., Kim, J., & Kim, K. (2019). Study on the Crystallization Rates of β‐ and ϵ‐form HNIW in in‐situ Raman Spectroscopy and FBRM. Propellants, Explosives, Pyrotechnics, 45(3), 422– 430. doi.org/10.1002/prep.201900194
  • Maloney, M. T., Jones, B. P., Olivier, M. A., Magano, J., Wang, K., Ide, N. D., Palm, A. S., Bill, D. R., Leeman, K. R., Sutherland, K., Draper, J., Daly, A. M., Keane, J., Lynch, D., O’Brien, M., & Tuohy, J. (2016). Palbociclib Commercial Manufacturing Process Development. Part II: Regioselective Heck Coupling with Polymorph Control for Processability. Organic Process Research & Development, 20(7), 1203–1216. doi.org/10.1021/acs.oprd.6b00069
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